AutismKB 2.0

Annotation Detail for TNFRSF21


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Basic Information Top
Gene Symbol:TNFRSF21 ( BM-018,DR6,MGC31965 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 21
Band: 6p12.3
Quick LinksEntrez ID:27242; OMIM: 605732; Uniprot ID:TNR21_HUMAN; ENSEMBL ID: ENSG00000146072; HGNC ID: 13469
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body16 / 70761226
blastocyst10 / 62319160
fetus14 / 56401224
neonate3 / 3109796
infant1 / 2362042
juvenile1 / 5555617
adult94 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor5 / 26384518
glioma7 / 10688365
head and neck tumor18 / 136302132
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal192 / 336030757
ovarian tumor3 / 7668239
pancreatic tumor22 / 104616210
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder16 / 29757537
blood0 / 1234780 
bone4 / 7165555
bone marrow1 / 4880120
brain124 / 1100989112
cervix1 / 4817120
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue34 / 215722157
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine18 / 23447276
kidney10 / 21177747
larynx1 / 2414541
liver0 / 2077430 
lung11 / 33697432
lymph0 / 442700 
lymph node3 / 9161032
mammary gland1 / 1532716
mouth14 / 67052208
muscle1 / 1077159
nerve1 / 1576863
ovary3 / 10205129
pancreas28 / 214812130
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta18 / 28082564
prostate9 / 18934547
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach1 / 9661910
testis16 / 33044248
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea22 / 52413419
umbilical cord2 / 13680146
uterus9 / 23287838
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214581_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.35
Adipocyte8.9
AdrenalCortex10
Adrenalgland7.45
Amygdala22.6
Appendix9.85
AtrioventricularNode8.1
BDCA4+_DentriticCells337.05
Bonemarrow8.95
BronchialEpithelialCells46.2
CD105+_Endothelial8.9
CD14+_Monocytes9.15
CD19+_BCells(neg._sel.)8.65
CD33+_Myeloid10.15
CD34+12.45
CD4+_Tcells8.9
CD56+_NKCells9.7
CD71+_EarlyErythroid8.15
CD8+_Tcells7.85
CardiacMyocytes22.85
Caudatenucleus8.15
Cerebellum8.05
CerebellumPeduncles12.4
CiliaryGanglion7.2
CingulateCortex9.5
Colorectaladenocarcinoma8.55
DorsalRootGanglion10
FetalThyroid8.55
Fetalbrain9.9
Fetalliver7.4
Fetallung8.6
GlobusPallidus8
Heart13.4
Hypothalamus19.85
Kidney26.1
Leukemia_chronicMyelogenousK-5627.5
Leukemia_promyelocytic-HL-607.35
Leukemialymphoblastic(MOLT-4)6.6
Liver12.05
Lung9.7
Lymphnode6.75
Lymphoma_burkitts(Daudi)11.15
Lymphoma_burkitts(Raji)12.6
MedullaOblongata7.55
OccipitalLobe12.8
OlfactoryBulb7.05
Ovary6.55
Pancreas7.4
PancreaticIslet47.35
ParietalLobe11.7
Pituitary10.1
Placenta69.1
Pons10.55
PrefrontalCortex12.9
Prostate10.6
Salivarygland7.45
SkeletalMuscle11.8
Skin8.8
SmoothMuscle91.45
Spinalcord33.45
SubthalamicNucleus8.6
SuperiorCervicalGanglion12.6
TemporalLobe8.25
Testis7.1
TestisGermCell7
TestisIntersitial7.75
TestisLeydigCell9.05
TestisSeminiferousTubule7.25
Thalamus15.25
Thymus7.5
Thyroid9.6
Tongue8.9
Tonsil10
Trachea11.95
TrigeminalGanglion10.05
Uterus7
UterusCorpus13.55
WholeBlood8.95
Wholebrain25.7
colon14
pineal_day18.08
pineal_night15.4
retina13.975
small_intestine8.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P42065
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.25 ± 0.41
Basal Forebrain6.07 ± 0.43
Basal Part of Pons6.52 ± 0.39
Cerebellar Cortex5.73 ± 0.42
Cerebellar Nuclei6.81 ± 0.32
Claustrum6.67 ± 0.65
Epithalamus5.28 ± 0.48
Frontal Lobe6.22 ± 0.55
Globus Pallidus7.15 ± 0.39
Hypothalamus5.71 ± 0.62
Insula5.97 ± 0.32
Limbic Lobe6.43 ± 0.56
Mesencephalon6.36 ± 0.64
Myelencephalon6.19 ± 0.63
Occipital Lobe6.09 ± 0.55
Parietal Lobe6.38 ± 0.6
Pontine Tegmentum6.13 ± 0.46
Striatum5.78 ± 0.73
Subthalamus6.25 ± 0.26
Temporal Lobe6.12 ± 0.47
Thalamus6.5 ± 0.45
White Matter7.55 ± 0.82
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfrsf21CBCerebellum44.06
100
Tnfrsf21CTXCerebral cortex100
100
Tnfrsf21HIPHippocampal region100
100
Tnfrsf21HPFHippocampal formation100
100
Tnfrsf21HYHypothalamus100
100
Tnfrsf21LSXLateral septal complex83.37
79.47
Tnfrsf21MBMidbrain93.93
100
Tnfrsf21MYMedulla98.32
100
Tnfrsf21OLFOlfactory bulb100
100
Tnfrsf21PPons92.12
100
Tnfrsf21PALPallidum92.23
100
Tnfrsf21RHPRetrohippocampal region100
100
Tnfrsf21sAMYStriatum-like amygdalar nuclei100
100
Tnfrsf21STRStriatum75.45
79
Tnfrsf21STRdStriatum dorsal region51.05
51.02
Tnfrsf21STRvStriatum ventral region92.89
91.33
Tnfrsf21THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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