AutismKB 2.0

Annotation Detail for SESN1


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Basic Information Top
Gene Symbol:SESN1 ( MGC138241,MGC142129,PA26,RP11-787I22.1,SEST1 )
Gene Full Name: sestrin 1
Band: 6q21
Quick LinksEntrez ID:27244; OMIM: 606103; Uniprot ID:SESN1_HUMAN; ENSEMBL ID: ENSG00000080546; HGNC ID: 21595
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus36 / 56401263
neonate1 / 3109732
infant0 / 236200 
juvenile3 / 5555653
adult71 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor13 / 26384549
glioma7 / 10688365
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal179 / 336030753
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer8 / 10268077
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood4 / 12347832
bone3 / 7165541
bone marrow3 / 4880161
brain69 / 110098962
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus1 / 2020949
eye9 / 21105442
heart9 / 89626100
intestine10 / 23447242
kidney9 / 21177742
larynx2 / 2414582
liver5 / 20774324
lung5 / 33697414
lymph0 / 442700 
lymph node2 / 9161021
mammary gland1 / 1532716
mouth4 / 6705259
muscle3 / 10771527
nerve1 / 1576863
ovary2 / 10205119
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland3 / 16585180
placenta15 / 28082553
prostate18 / 18934595
salivary gland0 / 201550 
skin4 / 21057418
spleen5 / 5395292
stomach0 / 966190 
testis44 / 330442133
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus11 / 23287847
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218346_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.75
Adipocyte33.4
AdrenalCortex12.1
Adrenalgland25.35
Amygdala50.95
Appendix31.55
AtrioventricularNode21.1
BDCA4+_DentriticCells27.15
Bonemarrow22.8
BronchialEpithelialCells23.95
CD105+_Endothelial11.05
CD14+_Monocytes13.95
CD19+_BCells(neg._sel.)86.65
CD33+_Myeloid28.6
CD34+43.85
CD4+_Tcells103.2
CD56+_NKCells37.85
CD71+_EarlyErythroid15.25
CD8+_Tcells87.9
CardiacMyocytes35.7
Caudatenucleus35.75
Cerebellum28.75
CerebellumPeduncles38.5
CiliaryGanglion9.55
CingulateCortex47.15
Colorectaladenocarcinoma16
DorsalRootGanglion13.45
FetalThyroid66.8
Fetalbrain35.8
Fetalliver20
Fetallung60.65
GlobusPallidus24.5
Heart15.6
Hypothalamus41.25
Kidney16.25
Leukemia_chronicMyelogenousK-56214.75
Leukemia_promyelocytic-HL-6034.35
Leukemialymphoblastic(MOLT-4)11.15
Liver24.5
Lung40.5
Lymphnode30
Lymphoma_burkitts(Daudi)52.25
Lymphoma_burkitts(Raji)31.35
MedullaOblongata36.1
OccipitalLobe41.55
OlfactoryBulb42.35
Ovary35.6
Pancreas19.3
PancreaticIslet74.75
ParietalLobe31.75
Pituitary41.45
Placenta89.6
Pons33.35
PrefrontalCortex185.2
Prostate48.5
Salivarygland27.95
SkeletalMuscle54.1
Skin18.5
SmoothMuscle34.55
Spinalcord37.9
SubthalamicNucleus31.15
SuperiorCervicalGanglion29.8
TemporalLobe32.05
Testis49.45
TestisGermCell182.75
TestisIntersitial29.5
TestisLeydigCell35.55
TestisSeminiferousTubule60.25
Thalamus35.65
Thymus15.45
Thyroid72.9
Tongue33.55
Tonsil19.2
Trachea18.2
TrigeminalGanglion27.55
Uterus41.35
UterusCorpus27.9
WholeBlood29.75
Wholebrain42.4
colon25
pineal_day62.52
pineal_night53.98
retina36.45
small_intestine38.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P346339
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.87 ± 0.42
Basal Forebrain6.89 ± 0.35
Basal Part of Pons7.32 ± 0.37
Cerebellar Cortex7.07 ± 0.33
Cerebellar Nuclei6.77 ± 0.54
Claustrum6.57 ± 0.44
Epithalamus7.25 ± 0.35
Frontal Lobe6.72 ± 0.39
Globus Pallidus6.38 ± 0.45
Hypothalamus6.74 ± 0.38
Insula6.85 ± 0.31
Limbic Lobe6.91 ± 0.42
Mesencephalon6.7 ± 0.43
Myelencephalon6.79 ± 0.39
Occipital Lobe7.17 ± 0.29
Parietal Lobe6.85 ± 0.37
Pontine Tegmentum6.78 ± 0.31
Striatum6.95 ± 0.39
Subthalamus6.82 ± 0.4
Temporal Lobe6.79 ± 0.38
Thalamus6.76 ± 0.32
White Matter6.97 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sesn1CBCerebellum76
85.49
Sesn1CTXCerebral cortex84.17
77.76
Sesn1HIPHippocampal region73.01
98.11
Sesn1HPFHippocampal formation75.2
91.72
Sesn1HYHypothalamus18.64
15.59
Sesn1LSXLateral septal complex52.12
48.23
Sesn1MBMidbrain23.06
21.99
Sesn1MYMedulla31.47
35.8
Sesn1OLFOlfactory bulb78.58
80.43
Sesn1PPons21
22.87
Sesn1PALPallidum21.98
19.78
Sesn1RHPRetrohippocampal region78.62
77.93
Sesn1sAMYStriatum-like amygdalar nuclei47.38
38.22
Sesn1STRStriatum49.67
40.62
Sesn1STRdStriatum dorsal region47.82
38.38
Sesn1STRvStriatum ventral region55.75
46.37
Sesn1THThalamus31.34
29.82
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00538163 13 347 359 DEEEASQEEMASR Peptide Atlas
SESN1_HUMAN_118 10 118 127 HYIGIMAAAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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