AutismKB 2.0

Annotation Detail for PDCD4


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Basic Information Top
Gene Symbol:PDCD4 ( H731,MGC33046,MGC33047 )
Gene Full Name: programmed cell death 4 (neoplastic transformation inhibitor)
Band: 10q25.2
Quick LinksEntrez ID:27250; OMIM: 608610; Uniprot ID:PDCD4_HUMAN; ENSEMBL ID: ENSG00000150593; HGNC ID: 8763
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus63 / 564012111
neonate3 / 3109796
infant1 / 2362042
juvenile12 / 55556215
adult392 / 1939121202
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor46 / 94178488
cervical tumor3 / 3436687
chondrosarcoma10 / 82823120
colorectal tumor15 / 114246131
esophageal tumor2 / 17290115
gastrointestinal tumor21 / 119369175
germ cell tumor19 / 26384572
glioma1 / 1068839
head and neck tumor58 / 136302425
kidney tumor4 / 6895958
leukemia19 / 95842198
liver tumor7 / 9635972
lung tumor7 / 10312767
lymphoma5 / 7175569
non-neoplasia12 / 97250123
normal440 / 3360307130
ovarian tumor6 / 7668278
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer24 / 102680233
retinoblastoma1 / 4635621
skin tumor11 / 12494988
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland2 / 3319760
ascites12 / 40015299
bladder4 / 29757134
blood40 / 123478323
bone4 / 7165555
bone marrow6 / 48801122
brain80 / 110098972
cervix6 / 48171124
connective tissue20 / 149255133
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus3 / 20209148
eye19 / 21105490
heart7 / 8962678
intestine35 / 234472149
kidney16 / 21177775
larynx12 / 24145496
liver18 / 20774386
lung33 / 33697497
lymph3 / 4427067
lymph node5 / 9161054
mammary gland56 / 153271365
mouth23 / 67052343
muscle13 / 107715120
nerve2 / 15768126
ovary8 / 10205178
pancreas23 / 214812107
parathyroid10 / 20539486
pharynx5 / 41328120
pituitary gland7 / 16585422
placenta69 / 280825245
prostate36 / 189345190
salivary gland0 / 201550 
skin19 / 21057490
spleen28 / 53952518
stomach12 / 96619124
testis20 / 33044260
thymus27 / 81131332
thyroid28 / 47473589
tonsil1 / 1699958
trachea20 / 52413381
umbilical cord2 / 13680146
uterus33 / 232878141
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212593_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1117.35
Adipocyte273.75
AdrenalCortex219.75
Adrenalgland129.45
Amygdala163.15
Appendix247.3
AtrioventricularNode66.55
BDCA4+_DentriticCells1259.6
Bonemarrow216.2
BronchialEpithelialCells379.85
CD105+_Endothelial1361.25
CD14+_Monocytes429.35
CD19+_BCells(neg._sel.)1621.45
CD33+_Myeloid391.25
CD34+1583.75
CD4+_Tcells2079.75
CD56+_NKCells1213.5
CD71+_EarlyErythroid268.85
CD8+_Tcells1869.65
CardiacMyocytes208.45
Caudatenucleus167.15
Cerebellum144.3
CerebellumPeduncles194.3
CiliaryGanglion59.55
CingulateCortex205.2
Colorectaladenocarcinoma191.25
DorsalRootGanglion122.15
FetalThyroid1247.25
Fetalbrain151.2
Fetalliver274.8
Fetallung375.5
GlobusPallidus141.3
Heart151.25
Hypothalamus317.25
Kidney124.4
Leukemia_chronicMyelogenousK-562183.7
Leukemia_promyelocytic-HL-60869.4
Leukemialymphoblastic(MOLT-4)159.85
Liver74.9
Lung133.65
Lymphnode573.65
Lymphoma_burkitts(Daudi)969.85
Lymphoma_burkitts(Raji)1196.9
MedullaOblongata107.45
OccipitalLobe185.3
OlfactoryBulb177
Ovary266.25
Pancreas986.45
PancreaticIslet1901.25
ParietalLobe197
Pituitary1044.6
Placenta850.6
Pons128.25
PrefrontalCortex356.75
Prostate549.45
Salivarygland916.5
SkeletalMuscle107.15
Skin387.5
SmoothMuscle258
Spinalcord268.25
SubthalamicNucleus143.85
SuperiorCervicalGanglion185.7
TemporalLobe130.7
Testis165.15
TestisGermCell228.25
TestisIntersitial196.45
TestisLeydigCell210.15
TestisSeminiferousTubule190.75
Thalamus183.15
Thymus309.15
Thyroid1749.35
Tongue551.7
Tonsil527.3
Trachea774.2
TrigeminalGanglion166.15
Uterus587.75
UterusCorpus244.35
WholeBlood879.45
Wholebrain131.75
colon1182.95
pineal_day621.64
pineal_night565.1
retina470.825
small_intestine706.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P258862
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.7 ± 0.37
Basal Forebrain8.93 ± 0.21
Basal Part of Pons8.44 ± 0.14
Cerebellar Cortex8.98 ± 0.11
Cerebellar Nuclei8.88 ± 0.2
Claustrum8.48 ± 0.21
Epithalamus9.25 ± 0.27
Frontal Lobe8.58 ± 0.25
Globus Pallidus9.14 ± 0.23
Hypothalamus9.06 ± 0.26
Insula8.72 ± 0.19
Limbic Lobe8.75 ± 0.36
Mesencephalon8.93 ± 0.27
Myelencephalon8.8 ± 0.29
Occipital Lobe9.1 ± 0.27
Parietal Lobe8.7 ± 0.29
Pontine Tegmentum8.86 ± 0.25
Striatum8.95 ± 0.36
Subthalamus9.09 ± 0.17
Temporal Lobe8.75 ± 0.23
Thalamus8.73 ± 0.22
White Matter9.64 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pdcd4CBCerebellum32.7
44.77
Pdcd4CTXCerebral cortex100
100
Pdcd4HIPHippocampal region100
100
Pdcd4HPFHippocampal formation100
100
Pdcd4HYHypothalamus54.07
55.15
Pdcd4LSXLateral septal complex78.1
74.9
Pdcd4MBMidbrain65.2
73.98
Pdcd4MYMedulla45.73
57.79
Pdcd4OLFOlfactory bulb99.87
100
Pdcd4PPons46.11
55.95
Pdcd4PALPallidum52.08
60.08
Pdcd4RHPRetrohippocampal region100
100
Pdcd4sAMYStriatum-like amygdalar nuclei82.58
84.18
Pdcd4STRStriatum53.73
50.32
Pdcd4STRdStriatum dorsal region37.01
32.36
Pdcd4STRvStriatum ventral region81.22
74.08
Pdcd4THThalamus54.18
56.45
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000766 16 268 283 AVGDGILCNTYIDSYK Peptide Atlas
PDCD4_HUMAN_197 15 197 211 SGVPVLAVSLALEGK PRIDE
PDCD4_HUMAN_256 11 256 266 APQLVGQFIAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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