AutismKB 2.0

Annotation Detail for GLDC


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Basic Information Top
Gene Symbol:GLDC ( GCE,GCSP,HYGN1,MGC138198,MGC138200 )
Gene Full Name: glycine dehydrogenase (decarboxylating)
Band: 9p24.1
Quick LinksEntrez ID:2731; OMIM: 238300; Uniprot ID:GCSP_HUMAN; ENSEMBL ID: ENSG00000178445; HGNC ID: 4313
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus10 / 56401217
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor19 / 26384572
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal74 / 336030722
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone1 / 7165513
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine4 / 23447217
kidney14 / 21177766
larynx0 / 241450 
liver12 / 20774357
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate0 / 1893450 
salivary gland0 / 201550 
skin6 / 21057428
spleen1 / 5395218
stomach0 / 966190 
testis13 / 33044239
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus7 / 23287830
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204836_at
Cell line Expression level Expression bar
721_B_lymphoblasts37.55
Adipocyte5.85
AdrenalCortex7.3
Adrenalgland5.25
Amygdala10.35
Appendix8.3
AtrioventricularNode9.45
BDCA4+_DentriticCells9
Bonemarrow6.35
BronchialEpithelialCells5.8
CD105+_Endothelial5.95
CD14+_Monocytes6.45
CD19+_BCells(neg._sel.)6.8
CD33+_Myeloid8.1
CD34+7.15
CD4+_Tcells5.8
CD56+_NKCells6.95
CD71+_EarlyErythroid5.6
CD8+_Tcells5.45
CardiacMyocytes8.4
Caudatenucleus5.55
Cerebellum7.05
CerebellumPeduncles7.05
CiliaryGanglion4.7
CingulateCortex7.65
Colorectaladenocarcinoma6.15
DorsalRootGanglion6.65
FetalThyroid5.85
Fetalbrain8.35
Fetalliver108.95
Fetallung5.45
GlobusPallidus4.6
Heart7.9
Hypothalamus7.05
Kidney108.2
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.3
Leukemialymphoblastic(MOLT-4)5.15
Liver110.1
Lung6.6
Lymphnode5.2
Lymphoma_burkitts(Daudi)7.7
Lymphoma_burkitts(Raji)8.85
MedullaOblongata7.3
OccipitalLobe7.2
OlfactoryBulb33.4
Ovary4.15
Pancreas4.8
PancreaticIslet6.35
ParietalLobe6.8
Pituitary7.35
Placenta140
Pons8.35
PrefrontalCortex11.65
Prostate7
Salivarygland7.55
SkeletalMuscle7.85
Skin5.9
SmoothMuscle6.5
Spinalcord7.45
SubthalamicNucleus6
SuperiorCervicalGanglion11.75
TemporalLobe7.05
Testis5.35
TestisGermCell5.6
TestisIntersitial6.35
TestisLeydigCell6.65
TestisSeminiferousTubule5.2
Thalamus6.3
Thymus4.55
Thyroid13.05
Tongue6
Tonsil6
Trachea5.2
TrigeminalGanglion15.35
Uterus4.8
UterusCorpus6
WholeBlood6.5
Wholebrain7.2
colon5.9
pineal_day130.8
pineal_night274.82
retina96.775
small_intestine5.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P123596
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.95 ± 0.42
Basal Forebrain6.81 ± 0.28
Basal Part of Pons6.26 ± 0.44
Cerebellar Cortex5.85 ± 0.45
Cerebellar Nuclei5.44 ± 0.63
Claustrum6.41 ± 0.9
Epithalamus6.89 ± 0.52
Frontal Lobe6.81 ± 0.47
Globus Pallidus5.98 ± 0.6
Hypothalamus6.57 ± 0.48
Insula7.06 ± 0.6
Limbic Lobe6.37 ± 0.77
Mesencephalon6.47 ± 0.66
Myelencephalon6.39 ± 0.69
Occipital Lobe6.18 ± 0.6
Parietal Lobe6.15 ± 0.55
Pontine Tegmentum6.4 ± 0.57
Striatum6.41 ± 0.62
Subthalamus5.74 ± 0.4
Temporal Lobe6.49 ± 0.54
Thalamus6.35 ± 0.56
White Matter4.93 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GldcCBCerebellum56.19
77.21
GldcCTXCerebral cortex43.92
34.94
GldcHIPHippocampal region47.01
54.31
GldcHPFHippocampal formation51.79
52.68
GldcHYHypothalamus41.13
37.26
GldcLSXLateral septal complex22.03
21.53
GldcMBMidbrain29.95
30.66
GldcMYMedulla43.89
58.75
GldcOLFOlfactory bulb53.61
45.07
GldcPPons33.26
37.88
GldcPALPallidum17.88
19.01
GldcRHPRetrohippocampal region56.13
48.78
GldcsAMYStriatum-like amygdalar nuclei34.22
28.2
GldcSTRStriatum22.36
18.54
GldcSTRdStriatum dorsal region19.22
15.87
GldcSTRvStriatum ventral region24.13
18.52
GldcTHThalamus28.99
26.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00036195 20 107 126 MEDPVCENEILATLHAISSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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