AutismKB 2.0

Annotation Detail for EIF3K


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Basic Information Top
Gene Symbol:EIF3K ( EIF3-p28,EIF3S12,HSPC029,M9,MSTP001,PLAC-24,PLAC24,PRO1474,PTD001 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit K
Band: 19q13.2
Quick LinksEntrez ID:27335; OMIM: 609596; Uniprot ID:EIF3K_HUMAN; ENSEMBL ID: ENSG00000178982; HGNC ID: 24656
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst11 / 62319176
fetus84 / 564012148
neonate16 / 31097514
infant0 / 236200 
juvenile1 / 5555617
adult611 / 1939121315
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor63 / 94178668
cervical tumor4 / 34366116
chondrosarcoma11 / 82823132
colorectal tumor24 / 114246210
esophageal tumor2 / 17290115
gastrointestinal tumor12 / 119369100
germ cell tumor25 / 26384594
glioma37 / 106883346
head and neck tumor9 / 13630266
kidney tumor14 / 68959203
leukemia47 / 95842490
liver tumor6 / 9635962
lung tumor51 / 103127494
lymphoma14 / 71755195
non-neoplasia3 / 9725030
normal407 / 3360307121
ovarian tumor306 / 766823990
pancreatic tumor31 / 104616296
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer11 / 102680107
retinoblastoma2 / 4635643
skin tumor26 / 124949208
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor25 / 90257276
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland4 / 33197120
ascites6 / 40015149
bladder4 / 29757134
blood30 / 123478242
bone7 / 7165597
bone marrow89 / 488011823
brain93 / 110098984
cervix4 / 4817183
connective tissue13 / 14925587
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus3 / 20209148
eye25 / 211054118
heart28 / 89626312
intestine39 / 234472166
kidney39 / 211777184
larynx0 / 241450 
liver14 / 20774367
lung97 / 336974287
lymph11 / 44270248
lymph node5 / 9161054
mammary gland81 / 153271528
mouth5 / 6705274
muscle21 / 107715194
nerve0 / 157680 
ovary310 / 1020513037
pancreas48 / 214812223
parathyroid14 / 20539681
pharynx3 / 4132872
pituitary gland2 / 16585120
placenta21 / 28082574
prostate18 / 18934595
salivary gland3 / 20155148
skin52 / 210574246
spleen3 / 5395255
stomach10 / 96619103
testis10 / 33044230
thymus5 / 8113161
thyroid5 / 47473105
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord6 / 13680438
uterus39 / 232878167
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210501_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts1745.25
Adipocyte405.25
AdrenalCortex174.55
Adrenalgland216.75
Amygdala236.7
Appendix188.3
AtrioventricularNode30.35
BDCA4+_DentriticCells972.75
Bonemarrow287.7
BronchialEpithelialCells617.35
CD105+_Endothelial807
CD14+_Monocytes1526.3
CD19+_BCells(neg._sel.)1473.45
CD33+_Myeloid1094.45
CD34+1110.95
CD4+_Tcells1217.3
CD56+_NKCells1218.95
CD71+_EarlyErythroid637.75
CD8+_Tcells1101.3
CardiacMyocytes325.55
Caudatenucleus226.05
Cerebellum216
CerebellumPeduncles309
CiliaryGanglion53.65
CingulateCortex219.9
Colorectaladenocarcinoma464.2
DorsalRootGanglion94.8
FetalThyroid421.25
Fetalbrain176.55
Fetalliver131.7
Fetallung310.3
GlobusPallidus134
Heart1519.9
Hypothalamus390
Kidney310
Leukemia_chronicMyelogenousK-5621045.55
Leukemia_promyelocytic-HL-60798.5
Leukemialymphoblastic(MOLT-4)479.35
Liver297.25
Lung580.65
Lymphnode473.35
Lymphoma_burkitts(Daudi)1226.65
Lymphoma_burkitts(Raji)1064.7
MedullaOblongata147.9
OccipitalLobe206.4
OlfactoryBulb152.3
Ovary220.85
Pancreas196.2
PancreaticIslet352
ParietalLobe193.45
Pituitary334.65
Placenta288.6
Pons149.15
PrefrontalCortex260.55
Prostate336.05
Salivarygland343.1
SkeletalMuscle203.3
Skin152.7
SmoothMuscle508.65
Spinalcord304.25
SubthalamicNucleus188
SuperiorCervicalGanglion7.95
TemporalLobe236.1
Testis244.55
TestisGermCell165.85
TestisIntersitial125.25
TestisLeydigCell129.5
TestisSeminiferousTubule82.3
Thalamus321.45
Thymus645.1
Thyroid471.1
Tongue424.8
Tonsil415.5
Trachea225.1
TrigeminalGanglion56.4
Uterus217.25
UterusCorpus126.65
WholeBlood730.75
Wholebrain522.65
colon450.35
pineal_day505.38
pineal_night488.48
retina502.325
small_intestine577.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P330971
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.15 ± 0.33
Basal Forebrain10.23 ± 0.15
Basal Part of Pons10.68 ± 0.29
Cerebellar Cortex10.5 ± 0.3
Cerebellar Nuclei10.32 ± 0.4
Claustrum9.89 ± 0.51
Epithalamus10.36 ± 0.19
Frontal Lobe10.51 ± 0.32
Globus Pallidus10.27 ± 0.25
Hypothalamus10.61 ± 0.3
Insula10.43 ± 0.29
Limbic Lobe10.12 ± 0.47
Mesencephalon10.23 ± 0.38
Myelencephalon10.26 ± 0.45
Occipital Lobe9.8 ± 0.46
Parietal Lobe10.34 ± 0.36
Pontine Tegmentum10.32 ± 0.32
Striatum9.88 ± 0.34
Subthalamus10.66 ± 0.32
Temporal Lobe10.46 ± 0.35
Thalamus10.29 ± 0.3
White Matter10.02 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Eif3s12CBCerebellum19.52
21.24
Eif3s12CTXCerebral cortex23.98
18.34
Eif3s12HIPHippocampal region24.95
30.49
Eif3s12HPFHippocampal formation24.21
25.15
Eif3s12HYHypothalamus3.6
2.88
Eif3s12LSXLateral septal complex9.11
6.41
Eif3s12MBMidbrain23.16
22.95
Eif3s12MYMedulla26.69
33.12
Eif3s12OLFOlfactory bulb24.13
18.76
Eif3s12PPons25.51
28.97
Eif3s12PALPallidum5.39
4.71
Eif3s12RHPRetrohippocampal region22.11
16.95
Eif3s12sAMYStriatum-like amygdalar nuclei3.16
2.34
Eif3s12STRStriatum3.74
2.84
Eif3s12STRdStriatum dorsal region2.14
1.81
Eif3s12STRvStriatum ventral region6.55
4.44
Eif3s12THThalamus7.56
6.44
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
EIF3K_HUMAN_0 0 0 0 ENAYDLEANLAVLK PRIDE
EIF3K_HUMAN_0 0 0 0 WLLAEMLGDLSDSQLK PRIDE
EIF3K_HUMAN_155 16 155 170 WLLAEMLGDLSDSQLK PRIDE
EIF3K_HUMAN_16 15 16 30 GIDRYNPENLATLER PRIDE
EIF3K_HUMAN_2 7 2 8 AMFEQMR PRIDE
EIF3K_HUMAN_209 10 209 218 SVSSIMASSQ PRIDE
EIF3K_HUMAN_38 14 38 51 ENAYDLEANLAVLK PRIDE
EIF3K_HUMAN_86 14 86 99 CMIDQAHQEERPIR PRIDE
PAp00000561 14 73 86 ALTNLPHTDFTLCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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