AutismKB 2.0

Annotation Detail for KCNMB4


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Basic Information Top
Gene Symbol:KCNMB4 ( - )
Gene Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4
Band: 12q15
Quick LinksEntrez ID:27345; OMIM: 605223; Uniprot ID:KCMB4_HUMAN; ENSEMBL ID: ENSG00000135643; HGNC ID: 6289
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus17 / 56401230
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal58 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain18 / 110098916
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine7 / 23447229
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph1 / 4427022
lymph node4 / 9161043
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219287_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte4
AdrenalCortex4.8
Adrenalgland3.95
Amygdala8.95
Appendix5.75
AtrioventricularNode7.1
BDCA4+_DentriticCells4.25
Bonemarrow4.05
BronchialEpithelialCells4
CD105+_Endothelial4.15
CD14+_Monocytes4.3
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid5.25
CD34+5.15
CD4+_Tcells4.35
CD56+_NKCells4.8
CD71+_EarlyErythroid3.7
CD8+_Tcells3.85
CardiacMyocytes5
Caudatenucleus4.95
Cerebellum3.55
CerebellumPeduncles4.9
CiliaryGanglion4.8
CingulateCortex8.3
Colorectaladenocarcinoma4
DorsalRootGanglion4.6
FetalThyroid4.1
Fetalbrain6.4
Fetalliver3.7
Fetallung4.4
GlobusPallidus3.55
Heart5.4
Hypothalamus8.35
Kidney3.3
Leukemia_chronicMyelogenousK-5623.65
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)3.25
Liver5.25
Lung5.85
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.3
Lymphoma_burkitts(Raji)5.8
MedullaOblongata5
OccipitalLobe3.7
OlfactoryBulb7.55
Ovary3.3
Pancreas3.3
PancreaticIslet4.85
ParietalLobe4.4
Pituitary4.75
Placenta4.15
Pons4.85
PrefrontalCortex42.35
Prostate4.85
Salivarygland3.45
SkeletalMuscle4.85
Skin6.25
SmoothMuscle4.6
Spinalcord8.35
SubthalamicNucleus5.05
SuperiorCervicalGanglion6.1
TemporalLobe3.95
Testis3.5
TestisGermCell3.55
TestisIntersitial3.85
TestisLeydigCell4.05
TestisSeminiferousTubule4.2
Thalamus6.3
Thymus3.25
Thyroid5.1
Tongue4.15
Tonsil3.95
Trachea3.4
TrigeminalGanglion4.15
Uterus3.3
UterusCorpus3.6
WholeBlood4.45
Wholebrain24.45
colon4.1
pineal_day5.44
pineal_night5.94
retina7.9
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9391_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.51 ± 0.8
Basal Forebrain7.64 ± 0.28
Basal Part of Pons7.54 ± 0.71
Cerebellar Cortex8.04 ± 0.34
Cerebellar Nuclei7.38 ± 0.41
Claustrum7.76 ± 0.63
Epithalamus7.89 ± 0.55
Frontal Lobe8.28 ± 0.51
Globus Pallidus7.9 ± 0.54
Hypothalamus7.25 ± 0.46
Insula8.24 ± 0.42
Limbic Lobe8.12 ± 0.56
Mesencephalon7.73 ± 0.58
Myelencephalon7.9 ± 0.6
Occipital Lobe7.14 ± 0.7
Parietal Lobe7.89 ± 0.5
Pontine Tegmentum7.92 ± 0.59
Striatum7 ± 0.47
Subthalamus7.02 ± 0.79
Temporal Lobe8.19 ± 0.51
Thalamus8.06 ± 0.46
White Matter9.09 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Kcnmb4CBCerebellum31.2
53.76
Kcnmb4CTXCerebral cortex93.12
92.74
Kcnmb4HIPHippocampal region46.48
87.17
Kcnmb4HPFHippocampal formation54.49
84.46
Kcnmb4HYHypothalamus7.17
8.25
Kcnmb4LSXLateral septal complex3.53
5.31
Kcnmb4MBMidbrain2.58
3.19
Kcnmb4MYMedulla5.61
9.97
Kcnmb4OLFOlfactory bulb48.37
47.57
Kcnmb4PPons3.35
6.25
Kcnmb4PALPallidum25.95
35.08
Kcnmb4RHPRetrohippocampal region67.43
82
Kcnmb4sAMYStriatum-like amygdalar nuclei16.94
14.18
Kcnmb4STRStriatum11.21
12.75
Kcnmb4STRdStriatum dorsal region13.56
16.37
Kcnmb4STRvStriatum ventral region3.42
3.35
Kcnmb4THThalamus22.03
24.81
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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