AutismKB 2.0

Annotation Detail for GLI1


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Basic Information Top
Gene Symbol:GLI1 ( GLI )
Gene Full Name: GLI family zinc finger 1
Band: 12q13.3
Quick LinksEntrez ID:2735; OMIM: 165220; Uniprot ID:GLI1_HUMAN; ENSEMBL ID: ENSG00000111087; HGNC ID: 4317
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult7 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal21 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor29 / 125191231
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph3 / 4427067
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle27 / 107715250
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206646_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.65
Adipocyte9
AdrenalCortex8.95
Adrenalgland12.45
Amygdala8.85
Appendix8.55
AtrioventricularNode17.05
BDCA4+_DentriticCells9.4
Bonemarrow8.5
BronchialEpithelialCells7.8
CD105+_Endothelial8.55
CD14+_Monocytes9.05
CD19+_BCells(neg._sel.)9
CD33+_Myeloid10.75
CD34+10.85
CD4+_Tcells9.15
CD56+_NKCells9.25
CD71+_EarlyErythroid9.6
CD8+_Tcells8.05
CardiacMyocytes10.95
Caudatenucleus9.7
Cerebellum6.85
CerebellumPeduncles9.65
CiliaryGanglion6.55
CingulateCortex14.4
Colorectaladenocarcinoma8.4
DorsalRootGanglion7.25
FetalThyroid7.85
Fetalbrain9
Fetalliver7.35
Fetallung7
GlobusPallidus7.45
Heart10.8
Hypothalamus9.2
Kidney7.45
Leukemia_chronicMyelogenousK-5627.7
Leukemia_promyelocytic-HL-607.45
Leukemialymphoblastic(MOLT-4)7.1
Liver11.2
Lung8.7
Lymphnode7.25
Lymphoma_burkitts(Daudi)10.8
Lymphoma_burkitts(Raji)11.75
MedullaOblongata10.1
OccipitalLobe8.1
OlfactoryBulb8.6
Ovary6.5
Pancreas6.8
PancreaticIslet9.05
ParietalLobe8.95
Pituitary9.85
Placenta8.65
Pons11.6
PrefrontalCortex10.45
Prostate9.8
Salivarygland6.8
SkeletalMuscle9.95
Skin6.85
SmoothMuscle9.65
Spinalcord10
SubthalamicNucleus10.25
SuperiorCervicalGanglion9.9
TemporalLobe9.45
Testis7.25
TestisGermCell7.35
TestisIntersitial9.75
TestisLeydigCell9.1
TestisSeminiferousTubule12.65
Thalamus10.7
Thymus6.1
Thyroid10.55
Tongue9.1
Tonsil8.2
Trachea7.1
TrigeminalGanglion8.5
Uterus6.3
UterusCorpus7.6
WholeBlood7.6
Wholebrain6.6
colon7.55
pineal_day10.46
pineal_night9.66
retina9.7
small_intestine7.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P105251
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.55 ± 0.91
Basal Forebrain4.08 ± 0.67
Basal Part of Pons2.84 ± 0.53
Cerebellar Cortex4.56 ± 0.33
Cerebellar Nuclei3.41 ± 0.97
Claustrum3.33 ± 0.7
Epithalamus4.09 ± 0.88
Frontal Lobe3.83 ± 0.81
Globus Pallidus5.16 ± 0.79
Hypothalamus4.48 ± 1.04
Insula4.56 ± 0.58
Limbic Lobe3.56 ± 1.04
Mesencephalon4.06 ± 0.95
Myelencephalon4 ± 1.01
Occipital Lobe3.81 ± 0.91
Parietal Lobe3.95 ± 0.81
Pontine Tegmentum3.95 ± 0.98
Striatum1.66 ± 0.99
Subthalamus3.82 ± 0.74
Temporal Lobe3.82 ± 0.8
Thalamus4.6 ± 0.92
White Matter1.38 ± 0.79
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gli1CBCerebellum22.44
36.74
Gli1CTXCerebral cortex6.57
5.06
Gli1HIPHippocampal region2.95
3.04
Gli1HPFHippocampal formation2.15
2.24
Gli1HYHypothalamus3.65
2.58
Gli1LSXLateral septal complex2.37
2.17
Gli1MBMidbrain2.68
3.13
Gli1MYMedulla4.8
5.52
Gli1OLFOlfactory bulb15.48
13.4
Gli1PPons4.12
4.16
Gli1PALPallidum3.58
2.71
Gli1RHPRetrohippocampal region0.73
1.07
Gli1sAMYStriatum-like amygdalar nuclei1.79
1.78
Gli1STRStriatum3.54
2.66
Gli1STRdStriatum dorsal region2.45
2.02
Gli1STRvStriatum ventral region7.61
4.67
Gli1THThalamus9.44
8.82
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GLI1_HUMAN_1004 15 1004 1018 VGGTNPSCGHPEVGR PRIDE
GLI1_HUMAN_101 13 101 113 TSPSSLVAFINSR PRIDE
GLI1_HUMAN_162 10 162 171 GGMIPHPQSR PRIDE
GLI1_HUMAN_181 9 181 189 SELDMLVGK PRIDE
GLI1_HUMAN_295 8 295 302 HTGEKPHK PRIDE
GLI1_HUMAN_406 10 406 415 APSISTVEPK PRIDE
GLI1_HUMAN_519 13 519 531 LPSLSHTGTTVSR PRIDE
GLI1_HUMAN_543 15 543 557 SSSSSSISSAYTVSR PRIDE
GLI1_HUMAN_598 24 598 621 GGGTSPTAASSLDRIGGLPMPPWR PRIDE
GLI1_HUMAN_624 14 624 637 AEYPGYNPNAGVTR PRIDE
GLI1_HUMAN_659 43 659 701 SLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDAR PRIDE
GLI1_HUMAN_795 11 795 805 ALGGTYSQCPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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