AutismKB 2.0

Annotation Detail for PPPDE2


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Basic Information Top
Gene Symbol:PPPDE2 ( D15Wsu75e,DJ347H13.4,FAM152B,MGC138384 )
Gene Full Name: PPPDE peptidase domain containing 2
Band: 22q13.2
Quick LinksEntrez ID:27351; OMIM: NA; Uniprot ID:PPDE2_HUMAN; ENSEMBL ID: ENSG00000100418; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma5 / 7175569
non-neoplasia0 / 972500 
normal71 / 336030721
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain5 / 11009894
cervix4 / 4817183
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye3 / 21105414
heart4 / 8962644
intestine12 / 23447251
kidney13 / 21177761
larynx0 / 241450 
liver3 / 20774314
lung8 / 33697423
lymph4 / 4427090
lymph node3 / 9161032
mammary gland3 / 15327119
mouth1 / 6705214
muscle3 / 10771527
nerve1 / 1576863
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta18 / 28082564
prostate7 / 18934536
salivary gland0 / 201550 
skin6 / 21057428
spleen1 / 5395218
stomach4 / 9661941
testis4 / 33044212
thymus0 / 811310 
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212527_at
Cell line Expression level Expression bar
721_B_lymphoblasts186.5
Adipocyte12.05
AdrenalCortex7.1
Adrenalgland10.5
Amygdala7.65
Appendix10.45
AtrioventricularNode5.95
BDCA4+_DentriticCells9.5
Bonemarrow9.5
BronchialEpithelialCells74.5
CD105+_Endothelial5.5
CD14+_Monocytes9.3
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid14.05
CD34+5.25
CD4+_Tcells7.3
CD56+_NKCells6.75
CD71+_EarlyErythroid9.4
CD8+_Tcells6.4
CardiacMyocytes10.3
Caudatenucleus7.9
Cerebellum6.45
CerebellumPeduncles6.95
CiliaryGanglion5.35
CingulateCortex7.25
Colorectaladenocarcinoma7.15
DorsalRootGanglion5.9
FetalThyroid7.05
Fetalbrain6.6
Fetalliver9.35
Fetallung6.9
GlobusPallidus4.5
Heart74.5
Hypothalamus6.9
Kidney11.85
Leukemia_chronicMyelogenousK-5628
Leukemia_promyelocytic-HL-6034.45
Leukemialymphoblastic(MOLT-4)5.7
Liver164.6
Lung55.15
Lymphnode5.75
Lymphoma_burkitts(Daudi)41.15
Lymphoma_burkitts(Raji)89.95
MedullaOblongata10
OccipitalLobe7
OlfactoryBulb5.2
Ovary5.05
Pancreas6.2
PancreaticIslet8.5
ParietalLobe7.8
Pituitary9.3
Placenta8.85
Pons7.6
PrefrontalCortex7.4
Prostate10.8
Salivarygland7.4
SkeletalMuscle9.55
Skin6.05
SmoothMuscle21.35
Spinalcord7.45
SubthalamicNucleus5.7
SuperiorCervicalGanglion16.15
TemporalLobe7.3
Testis109.45
TestisGermCell95.25
TestisIntersitial91.3
TestisLeydigCell63.5
TestisSeminiferousTubule73.2
Thalamus8.1
Thymus10.25
Thyroid8.85
Tongue7.75
Tonsil7.8
Trachea6.1
TrigeminalGanglion7.75
Uterus5.35
UterusCorpus8
WholeBlood19
Wholebrain9.8
colon7.85
pineal_day7.2
pineal_night8.22
retina8.55
small_intestine7.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10129_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.05 ± 0.35
Basal Forebrain6.28 ± 0.26
Basal Part of Pons6.39 ± 0.27
Cerebellar Cortex6.02 ± 0.22
Cerebellar Nuclei6.55 ± 0.3
Claustrum6.03 ± 0.48
Epithalamus6.02 ± 0.43
Frontal Lobe6.31 ± 0.3
Globus Pallidus6.6 ± 0.24
Hypothalamus6.1 ± 0.25
Insula6.19 ± 0.41
Limbic Lobe6.28 ± 0.31
Mesencephalon6.25 ± 0.34
Myelencephalon6.28 ± 0.35
Occipital Lobe6.41 ± 0.29
Parietal Lobe6.3 ± 0.32
Pontine Tegmentum6.3 ± 0.39
Striatum6.6 ± 0.25
Subthalamus6.27 ± 0.6
Temporal Lobe6.25 ± 0.28
Thalamus6.37 ± 0.27
White Matter6.61 ± 0.05
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
D15Wsu75eCBCerebellum77.39
100
D15Wsu75eCTXCerebral cortex100
90.8
D15Wsu75eHIPHippocampal region87.71
100
D15Wsu75eHPFHippocampal formation90.3
100
D15Wsu75eHYHypothalamus80.8
66.28
D15Wsu75eLSXLateral septal complex59.35
45.5
D15Wsu75eMBMidbrain100
96.64
D15Wsu75eMYMedulla84.35
90.76
D15Wsu75eOLFOlfactory bulb97.04
100
D15Wsu75ePPons94.25
93.06
D15Wsu75ePALPallidum83.14
72.03
D15Wsu75eRHPRetrohippocampal region92.46
83.42
D15Wsu75esAMYStriatum-like amygdalar nuclei57.37
42.83
D15Wsu75eSTRStriatum71.69
56.2
D15Wsu75eSTRdStriatum dorsal region77.79
63.13
D15Wsu75eSTRvStriatum ventral region65.89
46.86
D15Wsu75eTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00095945 25 98 122 GEAYNLFEHNCNTFSNEVAQFLTGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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