AutismKB 2.0

Annotation Detail for GLI3


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Basic Information Top
Gene Symbol:GLI3 ( ACLS,GCPS,PAP-A,PAPA,PAPA1,PAPB,PHS,PPDIV )
Gene Full Name: GLI family zinc finger 3
Band: 7p14.1
Quick LinksEntrez ID:2737; OMIM: 165240; Uniprot ID:GLI3_HUMAN; ENSEMBL ID: ENSG00000106571; HGNC ID: 4319
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus34 / 56401260
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult44 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor16 / 26384560
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal94 / 336030727
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone6 / 7165583
bone marrow1 / 4880120
brain19 / 110098917
cervix0 / 481710 
connective tissue4 / 14925526
ear3 / 16212185
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye3 / 21105414
heart6 / 8962666
intestine1 / 2344724
kidney5 / 21177723
larynx1 / 2414541
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth3 / 6705244
muscle7 / 10771564
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate3 / 18934515
salivary gland1 / 2015549
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis19 / 33044257
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205201_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.9
Adipocyte77.35
AdrenalCortex60
Adrenalgland37.95
Amygdala41.2
Appendix86.65
AtrioventricularNode119.6
BDCA4+_DentriticCells32.65
Bonemarrow43.25
BronchialEpithelialCells40.05
CD105+_Endothelial46.95
CD14+_Monocytes43.25
CD19+_BCells(neg._sel.)42.75
CD33+_Myeloid48.5
CD34+52.15
CD4+_Tcells45.25
CD56+_NKCells44.8
CD71+_EarlyErythroid42.95
CD8+_Tcells34.3
CardiacMyocytes48
Caudatenucleus40.85
Cerebellum36.95
CerebellumPeduncles87.55
CiliaryGanglion83.35
CingulateCortex56.85
Colorectaladenocarcinoma92.5
DorsalRootGanglion91.7
FetalThyroid86
Fetalbrain45.5
Fetalliver39.2
Fetallung34.05
GlobusPallidus33.9
Heart56.4
Hypothalamus53.85
Kidney42.1
Leukemia_chronicMyelogenousK-56239.1
Leukemia_promyelocytic-HL-6038.3
Leukemialymphoblastic(MOLT-4)37.4
Liver63.75
Lung41.85
Lymphnode39.25
Lymphoma_burkitts(Daudi)58.9
Lymphoma_burkitts(Raji)45.1
MedullaOblongata57.7
OccipitalLobe45.45
OlfactoryBulb48.3
Ovary57.15
Pancreas42
PancreaticIslet45.9
ParietalLobe63.9
Pituitary63.45
Placenta114.95
Pons115.8
PrefrontalCortex58.05
Prostate47.25
Salivarygland49.1
SkeletalMuscle104.5
Skin90.05
SmoothMuscle52.45
Spinalcord45.95
SubthalamicNucleus50.95
SuperiorCervicalGanglion68.85
TemporalLobe65.25
Testis39.85
TestisGermCell51.2
TestisIntersitial66.9
TestisLeydigCell72.1
TestisSeminiferousTubule54.25
Thalamus50.6
Thymus31.65
Thyroid43.95
Tongue89.8
Tonsil44.9
Trachea38.25
TrigeminalGanglion106.35
Uterus48.4
UterusCorpus55.75
WholeBlood35.45
Wholebrain28.9
colon45.65
pineal_day47.36
pineal_night45.9
retina63.375
small_intestine33.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12782_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.63 ± 0.69
Basal Forebrain3.24 ± 0.49
Basal Part of Pons3.06 ± 0.54
Cerebellar Cortex2.97 ± 0.67
Cerebellar Nuclei4.01 ± 0.64
Claustrum3.71 ± 0.92
Epithalamus2.64 ± 0.62
Frontal Lobe3.43 ± 0.89
Globus Pallidus4.08 ± 0.39
Hypothalamus2.76 ± 0.51
Insula3.11 ± 0.64
Limbic Lobe3.54 ± 0.84
Mesencephalon3.64 ± 0.8
Myelencephalon3.62 ± 0.84
Occipital Lobe3.37 ± 0.82
Parietal Lobe3.49 ± 0.88
Pontine Tegmentum3.58 ± 0.79
Striatum4.38 ± 0.63
Subthalamus3.65 ± 0.06
Temporal Lobe3.3 ± 0.71
Thalamus3.94 ± 0.61
White Matter2.99 ± 0.96
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gli3CBCerebellum1.23
1.65
Gli3CTXCerebral cortex1.18
0.9
Gli3HIPHippocampal region1.08
0.84
Gli3HPFHippocampal formation1.06
0.89
Gli3HYHypothalamus0.87
0.75
Gli3LSXLateral septal complex0.12
0.11
Gli3MBMidbrain0.7
0.81
Gli3MYMedulla0.64
0.93
Gli3OLFOlfactory bulb3.28
2.27
Gli3PPons0.76
0.98
Gli3PALPallidum0.4
0.39
Gli3RHPRetrohippocampal region1.04
0.87
Gli3sAMYStriatum-like amygdalar nuclei1.51
1.78
Gli3STRStriatum0.53
0.45
Gli3STRdStriatum dorsal region0.37
0.23
Gli3STRvStriatum ventral region0.56
0.55
Gli3THThalamus0.77
0.62
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GLI3_HUMAN_876 10 876 885 SSEASQAEGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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