AutismKB 2.0

Annotation Detail for GLRB


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Basic Information Top
Gene Symbol:GLRB ( - )
Gene Full Name: glycine receptor, beta
Band: 4q32.1
Quick LinksEntrez ID:2743; OMIM: 138492; Uniprot ID:GLRB_HUMAN; ENSEMBL ID: ENSG00000109738; HGNC ID: 4329
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult34 / 193912117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal78 / 336030723
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain81 / 110098973
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart4 / 8962644
intestine0 / 2344720 
kidney10 / 21177747
larynx0 / 241450 
liver1 / 2077434
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland4 / 15327126
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary4 / 10205139
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta0 / 2808250 
prostate1 / 1893455
salivary gland1 / 2015549
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205280_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.5
Adipocyte5.55
AdrenalCortex6.75
Adrenalgland5
Amygdala335.6
Appendix7.2
AtrioventricularNode4.95
BDCA4+_DentriticCells5.8
Bonemarrow6.05
BronchialEpithelialCells5.4
CD105+_Endothelial5.7
CD14+_Monocytes5.9
CD19+_BCells(neg._sel.)5.85
CD33+_Myeloid6.85
CD34+6.8
CD4+_Tcells5.85
CD56+_NKCells6.45
CD71+_EarlyErythroid5.5
CD8+_Tcells5.2
CardiacMyocytes9.7
Caudatenucleus36.85
Cerebellum6.35
CerebellumPeduncles7.4
CiliaryGanglion4.85
CingulateCortex33
Colorectaladenocarcinoma5.6
DorsalRootGanglion4.9
FetalThyroid5.65
Fetalbrain28.5
Fetalliver5
Fetallung4.4
GlobusPallidus17.1
Heart9.1
Hypothalamus59.8
Kidney5
Leukemia_chronicMyelogenousK-5625.1
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)4.35
Liver8.35
Lung6.1
Lymphnode4.65
Lymphoma_burkitts(Daudi)7.4
Lymphoma_burkitts(Raji)8.5
MedullaOblongata23.05
OccipitalLobe96.55
OlfactoryBulb4.35
Ovary4.05
Pancreas4.8
PancreaticIslet6.2
ParietalLobe21.9
Pituitary7
Placenta5.55
Pons10.85
PrefrontalCortex123.5
Prostate6.6
Salivarygland5
SkeletalMuscle7.45
Skin5.35
SmoothMuscle6.45
Spinalcord6.45
SubthalamicNucleus33.15
SuperiorCervicalGanglion8.55
TemporalLobe12.8
Testis4.8
TestisGermCell4.45
TestisIntersitial4.75
TestisLeydigCell5.8
TestisSeminiferousTubule4.8
Thalamus27.25
Thymus4.25
Thyroid6.85
Tongue6.1
Tonsil5.55
Trachea4.7
TrigeminalGanglion6.7
Uterus4.45
UterusCorpus5.5
WholeBlood6.05
Wholebrain176.6
colon5.65
pineal_day13.16
pineal_night17.1
retina6.8
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10014_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.47 ± 0.29
Basal Forebrain7.85 ± 0.32
Basal Part of Pons8.73 ± 0.21
Cerebellar Cortex8.07 ± 0.28
Cerebellar Nuclei8.86 ± 0.51
Claustrum8.25 ± 0.36
Epithalamus7.81 ± 0.52
Frontal Lobe8.55 ± 0.45
Globus Pallidus7.8 ± 0.55
Hypothalamus8.3 ± 0.42
Insula8.55 ± 0.21
Limbic Lobe8.61 ± 0.5
Mesencephalon8.39 ± 0.53
Myelencephalon8.32 ± 0.49
Occipital Lobe8.65 ± 0.34
Parietal Lobe8.58 ± 0.48
Pontine Tegmentum8.51 ± 0.45
Striatum8.08 ± 0.67
Subthalamus9.36 ± 0.41
Temporal Lobe8.53 ± 0.33
Thalamus8.36 ± 0.36
White Matter6.9 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GlrbCBCerebellum47.53
73.81
GlrbCTXCerebral cortex82.89
71.03
GlrbHIPHippocampal region59.06
55.32
GlrbHPFHippocampal formation61.74
53.82
GlrbHYHypothalamus55.7
49.15
GlrbLSXLateral septal complex24.74
18.7
GlrbMBMidbrain69.54
78.5
GlrbMYMedulla93.91
100
GlrbOLFOlfactory bulb85.19
70.55
GlrbPPons81.18
100
GlrbPALPallidum43.78
49.79
GlrbRHPRetrohippocampal region65.53
50.9
GlrbsAMYStriatum-like amygdalar nuclei47.17
36.64
GlrbSTRStriatum19.85
15.6
GlrbSTRdStriatum dorsal region11.14
9.04
GlrbSTRvStriatum ventral region32
22.56
GlrbTHThalamus50.94
55.99
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GLRB_HUMAN_51 12 51 62 VPANSTSNILNR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018