AutismKB 2.0

Annotation Detail for GLS


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Basic Information Top
Gene Symbol:GLS ( AAD20,DKFZp686O15119,FLJ10358,GLS1,KIAA0838 )
Gene Full Name: glutaminase
Band: 2q32.2
Quick LinksEntrez ID:2744; OMIM: 138280; Uniprot ID:GLSK_HUMAN; ENSEMBL ID: ENSG00000115419; HGNC ID: 4331
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst4 / 6231964
fetus38 / 56401267
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult174 / 193912189
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor8 / 9417884
cervical tumor1 / 3436629
chondrosarcoma18 / 82823217
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor16 / 119369134
germ cell tumor23 / 26384587
glioma4 / 10688337
head and neck tumor7 / 13630251
kidney tumor12 / 68959174
leukemia7 / 9584273
liver tumor6 / 9635962
lung tumor2 / 10312719
lymphoma6 / 7175583
non-neoplasia5 / 9725051
normal372 / 3360307110
ovarian tumor4 / 7668252
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor10 / 12494980
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder3 / 29757100
blood2 / 12347816
bone12 / 71655167
bone marrow9 / 48801184
brain124 / 1100989112
cervix1 / 4817120
connective tissue21 / 149255140
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye16 / 21105475
heart8 / 8962689
intestine18 / 23447276
kidney77 / 211777363
larynx2 / 2414582
liver13 / 20774362
lung19 / 33697456
lymph2 / 4427045
lymph node29 / 91610316
mammary gland11 / 15327171
mouth3 / 6705244
muscle7 / 10771564
nerve3 / 15768190
ovary6 / 10205158
pancreas44 / 214812204
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta8 / 28082528
prostate6 / 18934531
salivary gland1 / 2015549
skin14 / 21057466
spleen4 / 5395274
stomach16 / 96619165
testis16 / 33044248
thymus8 / 8113198
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord2 / 13680146
uterus15 / 23287864
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203157_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts54.4
Adipocyte35.4
AdrenalCortex8.3
Adrenalgland6.45
Amygdala120.65
Appendix7.75
AtrioventricularNode5.9
BDCA4+_DentriticCells33.25
Bonemarrow7.9
BronchialEpithelialCells7.85
CD105+_Endothelial7.6
CD14+_Monocytes7.95
CD19+_BCells(neg._sel.)24.6
CD33+_Myeloid9.95
CD34+10.8
CD4+_Tcells34.45
CD56+_NKCells48.4
CD71+_EarlyErythroid8.75
CD8+_Tcells22.45
CardiacMyocytes9.55
Caudatenucleus45
Cerebellum39.85
CerebellumPeduncles84.35
CiliaryGanglion5.45
CingulateCortex185
Colorectaladenocarcinoma7.55
DorsalRootGanglion6.65
FetalThyroid7.55
Fetalbrain28.05
Fetalliver6.6
Fetallung6.65
GlobusPallidus194.15
Heart10.35
Hypothalamus126.2
Kidney167.6
Leukemia_chronicMyelogenousK-5626.85
Leukemia_promyelocytic-HL-606.95
Leukemialymphoblastic(MOLT-4)6.15
Liver9.65
Lung8.05
Lymphnode21.45
Lymphoma_burkitts(Daudi)9.45
Lymphoma_burkitts(Raji)11.3
MedullaOblongata164.5
OccipitalLobe286.05
OlfactoryBulb6.15
Ovary5.2
Pancreas9.95
PancreaticIslet9.65
ParietalLobe240.95
Pituitary9.6
Placenta8.1
Pons90.75
PrefrontalCortex224.4
Prostate8.35
Salivarygland8.45
SkeletalMuscle8.8
Skin5.75
SmoothMuscle9
Spinalcord19.2
SubthalamicNucleus210.15
SuperiorCervicalGanglion8.85
TemporalLobe138
Testis6.7
TestisGermCell6.3
TestisIntersitial6.35
TestisLeydigCell7.7
TestisSeminiferousTubule7.15
Thalamus174.65
Thymus5.95
Thyroid9.95
Tongue7.6
Tonsil8.85
Trachea6.5
TrigeminalGanglion7.85
Uterus6.25
UterusCorpus7.05
WholeBlood8.6
Wholebrain73.5
colon10
pineal_day14.52
pineal_night12.88
retina19.55
small_intestine14.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14980_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.69 ± 0.54
Basal Forebrain9.34 ± 0.36
Basal Part of Pons10.91 ± 0.15
Cerebellar Cortex10.05 ± 0.18
Cerebellar Nuclei10.03 ± 0.6
Claustrum10.16 ± 0.39
Epithalamus8.81 ± 0.86
Frontal Lobe10.02 ± 0.42
Globus Pallidus8.26 ± 0.5
Hypothalamus9.95 ± 0.55
Insula10.07 ± 0.22
Limbic Lobe9.93 ± 0.61
Mesencephalon9.63 ± 0.58
Myelencephalon9.77 ± 0.75
Occipital Lobe10.02 ± 0.6
Parietal Lobe10.01 ± 0.57
Pontine Tegmentum9.74 ± 0.37
Striatum8.82 ± 0.73
Subthalamus10.29 ± 0.38
Temporal Lobe10.1 ± 0.33
Thalamus9.91 ± 0.41
White Matter8.02 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GlsCBCerebellum1.49
2.18
GlsCTXCerebral cortex4.71
3.65
GlsHIPHippocampal region19.97
19.98
GlsHPFHippocampal formation15.18
14.09
GlsHYHypothalamus0.43
0.4
GlsLSXLateral septal complex0.87
0.52
GlsMBMidbrain0.95
0.83
GlsMYMedulla6.85
10.87
GlsOLFOlfactory bulb11.68
10.46
GlsPPons15.07
21.84
GlsPALPallidum0.69
0.71
GlsRHPRetrohippocampal region7.3
6.09
GlssAMYStriatum-like amygdalar nuclei1.34
1.14
GlsSTRStriatum0.75
0.66
GlsSTRdStriatum dorsal region0.65
0.65
GlsSTRvStriatum ventral region0.67
0.43
GlsTHThalamus2.99
2.53
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GLSK_HUMAN_0 0 0 0 QGLLPSLEDLLFYTIAEGQEK PRIDE
GLSK_HUMAN_0 0 0 0 QGLLPSLEDLLFYTIAEGQEKIPVHK PRIDE
GLSK_HUMAN_0 0 0 0 TALHVAAAEGHVEVVK PRIDE
GLSK_HUMAN_132 21 132 152 QGLLPSLEDLLFYTIAEGQEK PRIDE
GLSK_HUMAN_132 26 132 157 QGLLPSLEDLLFYTIAEGQEKIPVHK PRIDE
GLSK_HUMAN_320 26 320 345 LFLNEDDKPHNPMVNAGAIVVTSLIK PRIDE
GLSK_HUMAN_321 26 321 346 LFLNEDDKPHNPMVNAGAIVVTSLIK PRIDE
GLSK_HUMAN_347 18 347 364 QGVNNAEKFDYVMQFLNK PRIDE
GLSK_HUMAN_355 10 355 364 FDYVMQFLNK PRIDE
GLSK_HUMAN_587 16 587 602 TALHVAAAEGHVEVVK PRIDE
GLSK_HUMAN_85 21 85 105 GSTHPQPGVSPPAAPAAPGPK PRIDE
PAp00001464 14 203 216 CVQSNIVLLTQAFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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