AutismKB 2.0

Annotation Detail for PCLO


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Basic Information Top
Gene Symbol:PCLO ( ACZ,DKFZp779G1236 )
Gene Full Name: piccolo (presynaptic cytomatrix protein)
Band: 7q21.11
Quick LinksEntrez ID:27445; OMIM: 604918; Uniprot ID:PCLO_HUMAN; ENSEMBL ID: ENSG00000186472; HGNC ID: 13406
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus27 / 56401247
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor6 / 26384522
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal93 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor14 / 124949112
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain47 / 110098942
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine0 / 2344720 
kidney3 / 21177714
larynx1 / 2414541
liver1 / 2077434
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland15 / 15327197
mouth0 / 670520 
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin14 / 21057466
spleen0 / 539520 
stomach1 / 9661910
testis6 / 33044218
thymus0 / 811310 
thyroid4 / 4747384
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210650_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte6.7
AdrenalCortex7.95
Adrenalgland6
Amygdala28.1
Appendix8.85
AtrioventricularNode6.7
BDCA4+_DentriticCells6.75
Bonemarrow7.55
BronchialEpithelialCells6.55
CD105+_Endothelial6.9
CD14+_Monocytes7.2
CD19+_BCells(neg._sel.)6.9
CD33+_Myeloid8.65
CD34+8.15
CD4+_Tcells6.95
CD56+_NKCells7.6
CD71+_EarlyErythroid6.5
CD8+_Tcells6.1
CardiacMyocytes11
Caudatenucleus6.25
Cerebellum6.85
CerebellumPeduncles8.45
CiliaryGanglion6.05
CingulateCortex7.3
Colorectaladenocarcinoma6.9
DorsalRootGanglion6.15
FetalThyroid6.9
Fetalbrain16.75
Fetalliver6.1
Fetallung5.25
GlobusPallidus5.3
Heart10
Hypothalamus7.1
Kidney6.15
Leukemia_chronicMyelogenousK-5626.15
Leukemia_promyelocytic-HL-606.15
Leukemialymphoblastic(MOLT-4)5.25
Liver10.2
Lung7.5
Lymphnode5.75
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)10.55
MedullaOblongata6.75
OccipitalLobe10.9
OlfactoryBulb5.35
Ovary6
Pancreas5.65
PancreaticIslet7.4
ParietalLobe7.85
Pituitary13.55
Placenta6.8
Pons6.7
PrefrontalCortex28.5
Prostate7.8
Salivarygland5.85
SkeletalMuscle9.9
Skin6.2
SmoothMuscle7.65
Spinalcord7.35
SubthalamicNucleus6.65
SuperiorCervicalGanglion12.35
TemporalLobe6.55
Testis5.85
TestisGermCell5.45
TestisIntersitial5.9
TestisLeydigCell7.25
TestisSeminiferousTubule5.9
Thalamus7.15
Thymus5.15
Thyroid8.2
Tongue7.4
Tonsil6.75
Trachea5.7
TrigeminalGanglion8.3
Uterus5.45
UterusCorpus6.9
WholeBlood7.45
Wholebrain6.7
colon6.95
pineal_day9.86
pineal_night10.3
retina8.325
small_intestine6.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P109876
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.84 ± 0.71
Basal Forebrain8.18 ± 0.62
Basal Part of Pons8.71 ± 0.31
Cerebellar Cortex8.82 ± 0.14
Cerebellar Nuclei7.06 ± 0.89
Claustrum8.17 ± 0.34
Epithalamus6.42 ± 1.28
Frontal Lobe8.32 ± 0.43
Globus Pallidus5.99 ± 1.05
Hypothalamus7.95 ± 0.63
Insula8.38 ± 0.31
Limbic Lobe8.38 ± 0.73
Mesencephalon7.77 ± 0.94
Myelencephalon7.97 ± 0.95
Occipital Lobe7.62 ± 0.87
Parietal Lobe8.32 ± 0.5
Pontine Tegmentum7.91 ± 0.78
Striatum6.35 ± 0.87
Subthalamus8.73 ± 0.33
Temporal Lobe8.29 ± 0.35
Thalamus8.28 ± 0.54
White Matter4.9 ± 0.79
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PcloCBCerebellum19.78
19.78
PcloCTXCerebral cortex71.06
60.71
PcloHIPHippocampal region41.52
74.89
PcloHPFHippocampal formation44.86
60.83
PcloHYHypothalamus2.88
2.13
PcloLSXLateral septal complex11.47
9.07
PcloMBMidbrain7.61
6.3
PcloMYMedulla11.91
11.73
PcloOLFOlfactory bulb37.74
38.34
PcloPPons7.59
7.23
PcloPALPallidum4.42
4.15
PcloRHPRetrohippocampal region50.09
47.47
PclosAMYStriatum-like amygdalar nuclei8.93
6.81
PcloSTRStriatum10.71
8.54
PcloSTRdStriatum dorsal region11.31
9.43
PcloSTRvStriatum ventral region9.42
6.33
PcloTHThalamus15.5
14.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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