AutismKB 2.0

Annotation Detail for GLUD1


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Basic Information Top
Gene Symbol:GLUD1 ( GDH,GDH1,GLUD,MGC132003 )
Gene Full Name: glutamate dehydrogenase 1
Band: 10q23.2
Quick LinksEntrez ID:2746; OMIM: 138130; Uniprot ID:DHE3_HUMAN; ENSEMBL ID: ENSG00000148672; HGNC ID: 4335
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst2 / 6231932
fetus62 / 564012109
neonate2 / 3109764
infant1 / 2362042
juvenile5 / 5555689
adult179 / 193912192
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor13 / 94178138
cervical tumor3 / 3436687
chondrosarcoma7 / 8282384
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor14 / 119369117
germ cell tumor22 / 26384583
glioma7 / 10688365
head and neck tumor17 / 136302124
kidney tumor8 / 68959116
leukemia11 / 95842114
liver tumor11 / 96359114
lung tumor2 / 10312719
lymphoma6 / 7175583
non-neoplasia11 / 97250113
normal299 / 336030788
ovarian tumor3 / 7668239
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer12 / 102680116
retinoblastoma4 / 4635686
skin tumor7 / 12494956
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder3 / 29757100
blood9 / 12347872
bone10 / 71655139
bone marrow9 / 48801184
brain104 / 110098994
cervix3 / 4817162
connective tissue16 / 149255107
ear1 / 1621261
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye16 / 21105475
heart2 / 8962622
intestine16 / 23447268
kidney37 / 211777174
larynx11 / 24145455
liver30 / 207743144
lung18 / 33697453
lymph3 / 4427067
lymph node8 / 9161087
mammary gland16 / 153271104
mouth7 / 67052104
muscle6 / 10771555
nerve3 / 15768190
ovary4 / 10205139
pancreas22 / 214812102
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta26 / 28082592
prostate19 / 189345100
salivary gland0 / 201550 
skin23 / 210574109
spleen2 / 5395237
stomach11 / 96619113
testis25 / 33044275
thymus5 / 8113161
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus16 / 23287868
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200947_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts557.1
Adipocyte165.7
AdrenalCortex140.2
Adrenalgland156.95
Amygdala1094.2
Appendix55.95
AtrioventricularNode31
BDCA4+_DentriticCells224.9
Bonemarrow53.7
BronchialEpithelialCells423.5
CD105+_Endothelial78.9
CD14+_Monocytes277.55
CD19+_BCells(neg._sel.)216.55
CD33+_Myeloid300.4
CD34+182.85
CD4+_Tcells185.15
CD56+_NKCells236.7
CD71+_EarlyErythroid36.95
CD8+_Tcells166.65
CardiacMyocytes147.1
Caudatenucleus422.95
Cerebellum112.65
CerebellumPeduncles183.25
CiliaryGanglion44.5
CingulateCortex405.7
Colorectaladenocarcinoma155.9
DorsalRootGanglion50.3
FetalThyroid141.45
Fetalbrain184.05
Fetalliver1128.7
Fetallung214.15
GlobusPallidus170.85
Heart95.05
Hypothalamus844.15
Kidney462.5
Leukemia_chronicMyelogenousK-562132.5
Leukemia_promyelocytic-HL-60249.15
Leukemialymphoblastic(MOLT-4)226.65
Liver568.45
Lung114.6
Lymphnode128.5
Lymphoma_burkitts(Daudi)241.4
Lymphoma_burkitts(Raji)244.9
MedullaOblongata317.05
OccipitalLobe407
OlfactoryBulb110.9
Ovary68.15
Pancreas133.25
PancreaticIslet150.9
ParietalLobe233.35
Pituitary169.6
Placenta180.5
Pons169.6
PrefrontalCortex509.3
Prostate324.35
Salivarygland69.3
SkeletalMuscle71.4
Skin54.95
SmoothMuscle100.2
Spinalcord602.3
SubthalamicNucleus178.55
SuperiorCervicalGanglion40.65
TemporalLobe176.2
Testis79.15
TestisGermCell88.95
TestisIntersitial35.65
TestisLeydigCell44.75
TestisSeminiferousTubule48.8
Thalamus427.3
Thymus151.15
Thyroid280.55
Tongue61.45
Tonsil109.05
Trachea148.9
TrigeminalGanglion32.4
Uterus118.15
UterusCorpus48.9
WholeBlood203.9
Wholebrain401.55
colon247.15
pineal_day383.54
pineal_night316.56
retina445.075
small_intestine271.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P138665
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala12.53 ± 0.35
Basal Forebrain12.49 ± 0.27
Basal Part of Pons11.59 ± 0.32
Cerebellar Cortex11.6 ± 0.25
Cerebellar Nuclei11.68 ± 0.36
Claustrum12.3 ± 0.5
Epithalamus12.2 ± 0.21
Frontal Lobe11.9 ± 0.41
Globus Pallidus13.01 ± 0.3
Hypothalamus12.29 ± 0.2
Insula12.02 ± 0.37
Limbic Lobe12.05 ± 0.52
Mesencephalon12.39 ± 0.47
Myelencephalon12.22 ± 0.44
Occipital Lobe12.27 ± 0.38
Parietal Lobe12.02 ± 0.48
Pontine Tegmentum12.14 ± 0.35
Striatum12.65 ± 0.35
Subthalamus11.94 ± 0.12
Temporal Lobe12.04 ± 0.34
Thalamus12.42 ± 0.36
White Matter12.18 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Glud1CBCerebellum6.6
7.01
Glud1CTXCerebral cortex2.17
1.8
Glud1HIPHippocampal region3.47
1.79
Glud1HPFHippocampal formation2.8
1.56
Glud1HYHypothalamus1.49
1.05
Glud1LSXLateral septal complex0.27
0.14
Glud1MBMidbrain2.78
2.6
Glud1MYMedulla7.67
7.67
Glud1OLFOlfactory bulb4.14
3.35
Glud1PPons6.32
5.6
Glud1PALPallidum0.96
0.87
Glud1RHPRetrohippocampal region1.65
1.12
Glud1sAMYStriatum-like amygdalar nuclei3.58
2.35
Glud1STRStriatum0.77
0.53
Glud1STRdStriatum dorsal region0.47
0.35
Glud1STRvStriatum ventral region0.42
0.27
Glud1THThalamus1.4
1.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DHE3_HUMAN_107 16 107 122 IIKPCNHVLSLSFPIR PRIDE
DHE3_HUMAN_124 12 124 135 DDGSWEVIEGYR PRIDE
DHE3_HUMAN_151 11 151 161 YSTDVSVDEVK PRIDE
DHE3_HUMAN_171 12 171 182 CAVVDVPFGGAK PRIDE
DHE3_HUMAN_204 8 204 211 RFTMELAK PRIDE
DHE3_HUMAN_213 19 213 231 GFIGPGIDVPAPDMSTGER PRIDE
DHE3_HUMAN_302 16 302 317 TFVVQGFGNVGLHSMR PRIDE
DHE3_HUMAN_346 17 346 362 ELEDFKLQHGSILGFPK PRIDE
DHE3_HUMAN_363 23 363 385 AKPYEGSILEADCDILIPAASEK PRIDE
DHE3_HUMAN_396 25 396 420 VKAKIIAEGANGPTTPEADKIFLER PRIDE
DHE3_HUMAN_399 21 399 419 IIAEGANGPTTPEADKIFLER PRIDE
DHE3_HUMAN_460 16 460 475 DSNYHLLMSVQESLER PRIDE
DHE3_HUMAN_480 16 480 495 HGGTIPIVPTAEFQDR PRIDE
DHE3_HUMAN_503 13 503 515 DIVHSGLAYTMER PRIDE
DHE3_HUMAN_504 13 504 516 DIVHSGLAYTMER PRIDE
DHE3_HUMAN_527 8 527 534 YNLGLDLR PRIDE
DHE3_HUMAN_535 10 535 544 TAAYVNAIEK PRIDE
DHE3_HUMAN_54 23 54 76 SEAVADREDDPNFFKMVEGFFDR PRIDE
DHE3_HUMAN_548 10 548 557 VYNEAGVTFT PRIDE
DHE3_HUMAN_68 8 68 75 MVEGFFDR PRIDE
DHE3_HUMAN_76 14 76 89 GASIVEDKLVEDLR PRIDE
PAp00000481 23 364 386 AKPYEGSILEADCDILIPAASEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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