AutismKB 2.0

Annotation Detail for GNA11


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Basic Information Top
Gene Symbol:GNA11 ( GNA-11 )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Band: 19p13.3
Quick LinksEntrez ID:2767; OMIM: 139313; Uniprot ID:GNA11_HUMAN; ENSEMBL ID: ENSG00000088256; HGNC ID: 4379
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult58 / 193912129
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus21 / 56401237
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor9 / 11424678
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma11 / 106883102
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal90 / 336030726
ovarian tumor5 / 7668265
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer7 / 10268068
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor0 / 2638450 
glioma9 / 10688384
head and neck tumor8 / 13630258
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal71 / 336030721
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone1 / 7165513
bone marrow1 / 4880120
brain24 / 110098921
cervix2 / 4817141
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye3 / 21105414
heart1 / 8962611
intestine20 / 23447285
kidney3 / 21177714
larynx0 / 241450 
liver4 / 20774319
lung12 / 33697435
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas18 / 21481283
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate9 / 18934547
salivary gland0 / 201550 
skin8 / 21057437
spleen1 / 5395218
stomach0 / 966190 
testis6 / 33044218
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites4 / 4001599
bladder1 / 2975733
blood1 / 1234788
bone7 / 7165597
bone marrow1 / 4880120
brain26 / 110098923
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye21 / 21105499
heart6 / 8962666
intestine10 / 23447242
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung11 / 33697432
lymph1 / 4427022
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate3 / 18934515
salivary gland8 / 20155396
skin11 / 21057452
spleen0 / 539520 
stomach2 / 9661920
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus14 / 23287860
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204248_at
Cell line Expression level Expression bar
721_B_lymphoblasts60.75
Adipocyte85.15
AdrenalCortex57.3
Adrenalgland109.1
Amygdala74.85
Appendix44.25
AtrioventricularNode38
BDCA4+_DentriticCells41.95
Bonemarrow51.15
BronchialEpithelialCells47.3
CD105+_Endothelial53.05
CD14+_Monocytes38.35
CD19+_BCells(neg._sel.)28.5
CD33+_Myeloid43.15
CD34+53.9
CD4+_Tcells58.7
CD56+_NKCells40.4
CD71+_EarlyErythroid50.3
CD8+_Tcells42.15
CardiacMyocytes51.5
Caudatenucleus44.9
Cerebellum72.85
CerebellumPeduncles224.75
CiliaryGanglion36.8
CingulateCortex102.65
Colorectaladenocarcinoma53
DorsalRootGanglion40.1
FetalThyroid57.35
Fetalbrain54.35
Fetalliver44.95
Fetallung45.8
GlobusPallidus43.4
Heart87.35
Hypothalamus66.7
Kidney80.65
Leukemia_chronicMyelogenousK-56247.75
Leukemia_promyelocytic-HL-6037.6
Leukemialymphoblastic(MOLT-4)31
Liver70.55
Lung516.2
Lymphnode41.75
Lymphoma_burkitts(Daudi)62.55
Lymphoma_burkitts(Raji)44.85
MedullaOblongata60.1
OccipitalLobe68.45
OlfactoryBulb58.55
Ovary35.45
Pancreas54.55
PancreaticIslet72.65
ParietalLobe56.3
Pituitary63.65
Placenta70.25
Pons61.25
PrefrontalCortex194.85
Prostate505.55
Salivarygland41.6
SkeletalMuscle58.3
Skin40.25
SmoothMuscle54.1
Spinalcord49.5
SubthalamicNucleus75.3
SuperiorCervicalGanglion55.3
TemporalLobe66.65
Testis169.55
TestisGermCell111.6
TestisIntersitial83.1
TestisLeydigCell65.35
TestisSeminiferousTubule85.65
Thalamus67.9
Thymus35.65
Thyroid79.75
Tongue50.05
Tonsil48.05
Trachea49.9
TrigeminalGanglion51.35
Uterus73.35
UterusCorpus37.45
WholeBlood21.05
Wholebrain179.5
colon343.5
pineal_day92.94
pineal_night92.66
retina272.425
small_intestine575.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9460_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.66 ± 0.61
Basal Forebrain5.79 ± 0.27
Basal Part of Pons6.05 ± 0.34
Cerebellar Cortex6.23 ± 0.3
Cerebellar Nuclei5.46 ± 0.28
Claustrum5.83 ± 0.47
Epithalamus5.67 ± 0.53
Frontal Lobe5.78 ± 0.43
Globus Pallidus5.1 ± 0.32
Hypothalamus5.65 ± 0.39
Insula5.92 ± 0.48
Limbic Lobe5.91 ± 0.4
Mesencephalon5.74 ± 0.43
Myelencephalon5.8 ± 0.48
Occipital Lobe5.96 ± 0.33
Parietal Lobe5.82 ± 0.43
Pontine Tegmentum5.73 ± 0.43
Striatum5.49 ± 0.35
Subthalamus5.65 ± 0.77
Temporal Lobe5.98 ± 0.37
Thalamus5.91 ± 0.35
White Matter5.54 ± 0.41
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GNA11_HUMAN_166 15 166 180 IATLGYLPTQQDVLR PRIDE
GNA11_HUMAN_181 21 181 201 VRVPTTGIIEYPFDLENIIFR PRIDE
GNA11_HUMAN_41 11 41 51 LLLLGTGESGK PRIDE
GNA11_HUMAN_77 15 77 91 LVYQNIFTAMQAMIR PRIDE
PAp00005539 27 312 338 MFVDLNPDSDKIIYSHFTCATDTENIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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