AutismKB 2.0

Annotation Detail for GNA12


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Basic Information Top
Gene Symbol:GNA12 ( MGC104623,MGC99644,NNX3,RMP,gep )
Gene Full Name: guanine nucleotide binding protein (G protein) alpha 12
Band: 7p22.3-p22.2
Quick LinksEntrez ID:2768; OMIM: 604394; Uniprot ID:GNA12_HUMAN; ENSEMBL ID: ENSG00000146535; HGNC ID: 4380
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus28 / 56401249
neonate1 / 3109732
infant3 / 23620127
juvenile2 / 5555635
adult137 / 193912170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma9 / 82823108
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor22 / 26384583
glioma16 / 106883149
head and neck tumor17 / 136302124
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor16 / 103127155
lymphoma3 / 7175541
non-neoplasia6 / 9725061
normal172 / 336030751
ovarian tumor6 / 7668278
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor16 / 124949128
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder2 / 2975767
blood2 / 12347816
bone5 / 7165569
bone marrow0 / 488010 
brain73 / 110098966
cervix0 / 481710 
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye18 / 21105485
heart2 / 8962622
intestine12 / 23447251
kidney7 / 21177733
larynx0 / 241450 
liver7 / 20774333
lung41 / 336974121
lymph2 / 4427045
lymph node3 / 9161032
mammary gland5 / 15327132
mouth4 / 6705259
muscle8 / 10771574
nerve1 / 1576863
ovary6 / 10205158
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta24 / 28082585
prostate9 / 18934547
salivary gland10 / 20155496
skin19 / 21057490
spleen2 / 5395237
stomach3 / 9661931
testis25 / 33044275
thymus4 / 8113149
thyroid2 / 4747342
tonsil1 / 1699958
trachea2 / 5241338
umbilical cord0 / 136800 
uterus20 / 23287885
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221737_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.75
Adipocyte22.25
AdrenalCortex22.85
Adrenalgland15.15
Amygdala24.95
Appendix16.85
AtrioventricularNode11.2
BDCA4+_DentriticCells30.25
Bonemarrow16.35
BronchialEpithelialCells13.2
CD105+_Endothelial15.05
CD14+_Monocytes20.75
CD19+_BCells(neg._sel.)24.5
CD33+_Myeloid17.7
CD34+19.45
CD4+_Tcells15.05
CD56+_NKCells15.45
CD71+_EarlyErythroid39.4
CD8+_Tcells14.3
CardiacMyocytes27.1
Caudatenucleus15.35
Cerebellum12.95
CerebellumPeduncles20.2
CiliaryGanglion14.45
CingulateCortex15.6
Colorectaladenocarcinoma13.2
DorsalRootGanglion13.75
FetalThyroid13.85
Fetalbrain15.9
Fetalliver11.65
Fetallung10.25
GlobusPallidus12.45
Heart21.6
Hypothalamus27.7
Kidney14.1
Leukemia_chronicMyelogenousK-56213
Leukemia_promyelocytic-HL-6012.65
Leukemialymphoblastic(MOLT-4)8.85
Liver18.5
Lung32.7
Lymphnode12.5
Lymphoma_burkitts(Daudi)21.1
Lymphoma_burkitts(Raji)23.45
MedullaOblongata12.25
OccipitalLobe13.45
OlfactoryBulb17.85
Ovary13.8
Pancreas11.75
PancreaticIslet18.25
ParietalLobe15.7
Pituitary18.15
Placenta26.45
Pons16.85
PrefrontalCortex19.2
Prostate22.2
Salivarygland11.55
SkeletalMuscle21.45
Skin11.75
SmoothMuscle22.25
Spinalcord29.85
SubthalamicNucleus14.7
SuperiorCervicalGanglion17.4
TemporalLobe15.45
Testis16
TestisGermCell20.05
TestisIntersitial12.4
TestisLeydigCell17.25
TestisSeminiferousTubule13.5
Thalamus18.35
Thymus12.35
Thyroid16.1
Tongue18.8
Tonsil16.1
Trachea11.05
TrigeminalGanglion22.35
Uterus18.15
UterusCorpus12.95
WholeBlood16.75
Wholebrain16.7
colon13.3
pineal_day29.92
pineal_night28.4
retina22.5
small_intestine16.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P354270
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.41 ± 0.66
Basal Forebrain3.72 ± 0.65
Basal Part of Pons2.92 ± 0.47
Cerebellar Cortex3.11 ± 0.43
Cerebellar Nuclei3.4 ± 0.63
Claustrum3.66 ± 0.64
Epithalamus3.77 ± 0.46
Frontal Lobe3.27 ± 0.56
Globus Pallidus4.78 ± 0.47
Hypothalamus3.17 ± 0.57
Insula3.59 ± 0.4
Limbic Lobe3.17 ± 0.62
Mesencephalon3.75 ± 0.61
Myelencephalon3.49 ± 0.66
Occipital Lobe3.68 ± 0.55
Parietal Lobe3.5 ± 0.73
Pontine Tegmentum3.62 ± 0.64
Striatum3.87 ± 0.67
Subthalamus3.56 ± 0.3
Temporal Lobe3.3 ± 0.68
Thalamus3.75 ± 0.51
White Matter4.44 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gna12CBCerebellum2.13
2.36
Gna12CTXCerebral cortex1.5
1.28
Gna12HIPHippocampal region0.95
1.08
Gna12HPFHippocampal formation1.39
1.2
Gna12HYHypothalamus0.18
0.22
Gna12LSXLateral septal complex0
0
Gna12MBMidbrain0.42
0.39
Gna12MYMedulla0.66
0.56
Gna12OLFOlfactory bulb0.72
0.48
Gna12PPons0.29
0.23
Gna12PALPallidum0.85
0.6
Gna12RHPRetrohippocampal region2.17
1.45
Gna12sAMYStriatum-like amygdalar nuclei0.32
0.33
Gna12STRStriatum1.03
0.67
Gna12STRdStriatum dorsal region1.53
0.99
Gna12STRvStriatum ventral region0.31
0.2
Gna12THThalamus0.67
0.61
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GNA12_HUMAN_0 0 0 0 ILLLGAGESGK PRIDE
GNA12_HUMAN_59 11 59 69 ILLLGAGESGK PRIDE
PAp00034939 11 60 70 ILLLGAGESGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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