AutismKB 2.0

Annotation Detail for GNAI1


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Basic Information Top
Gene Symbol:GNAI1 ( Gi )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Band: 7q21.11
Quick LinksEntrez ID:2770; OMIM: 139310; Uniprot ID:GNAI1_HUMAN; ENSEMBL ID: ENSG00000127955; HGNC ID: 4384
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus41 / 56401272
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult81 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor4 / 34366116
chondrosarcoma7 / 8282384
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor18 / 26384568
glioma7 / 10688365
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor6 / 9635962
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal214 / 336030763
ovarian tumor6 / 7668278
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone5 / 7165569
bone marrow0 / 488010 
brain122 / 1100989110
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye5 / 21105423
heart5 / 8962655
intestine12 / 23447251
kidney10 / 21177747
larynx1 / 2414541
liver11 / 20774352
lung13 / 33697438
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth7 / 67052104
muscle6 / 10771555
nerve1 / 1576863
ovary0 / 1020510 
pancreas11 / 21481251
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta22 / 28082578
prostate4 / 18934521
salivary gland0 / 201550 
skin23 / 210574109
spleen1 / 5395218
stomach0 / 966190 
testis16 / 33044248
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus13 / 23287855
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209576_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.85
Adipocyte11.75
AdrenalCortex10.45
Adrenalgland7.85
Amygdala156.75
Appendix10.6
AtrioventricularNode9.5
BDCA4+_DentriticCells7.5
Bonemarrow9.25
BronchialEpithelialCells26.45
CD105+_Endothelial8.1
CD14+_Monocytes8.45
CD19+_BCells(neg._sel.)8.5
CD33+_Myeloid9.6
CD34+10.7
CD4+_Tcells7.8
CD56+_NKCells8.6
CD71+_EarlyErythroid8.25
CD8+_Tcells6.75
CardiacMyocytes14.2
Caudatenucleus14.7
Cerebellum7.65
CerebellumPeduncles11.1
CiliaryGanglion7.3
CingulateCortex17.8
Colorectaladenocarcinoma8.2
DorsalRootGanglion8.15
FetalThyroid8.5
Fetalbrain57.55
Fetalliver7.8
Fetallung15.55
GlobusPallidus7.15
Heart13.15
Hypothalamus43.85
Kidney7.8
Leukemia_chronicMyelogenousK-5626.75
Leukemia_promyelocytic-HL-606.05
Leukemialymphoblastic(MOLT-4)4.85
Liver12.6
Lung9.15
Lymphnode6.3
Lymphoma_burkitts(Daudi)10.65
Lymphoma_burkitts(Raji)13.1
MedullaOblongata18.9
OccipitalLobe60.05
OlfactoryBulb15.25
Ovary7
Pancreas7.4
PancreaticIslet21.9
ParietalLobe30.25
Pituitary10.4
Placenta22.55
Pons11.8
PrefrontalCortex22.9
Prostate9.6
Salivarygland7.6
SkeletalMuscle12.75
Skin9.55
SmoothMuscle9.6
Spinalcord80.3
SubthalamicNucleus15.85
SuperiorCervicalGanglion13.35
TemporalLobe8.35
Testis9.3
TestisGermCell18.25
TestisIntersitial7.45
TestisLeydigCell9.2
TestisSeminiferousTubule7.5
Thalamus24.6
Thymus5.9
Thyroid27
Tongue9.9
Tonsil8
Trachea7.4
TrigeminalGanglion16.75
Uterus10.15
UterusCorpus8.35
WholeBlood8.55
Wholebrain40.3
colon23.4
pineal_day10.12
pineal_night9.62
retina25.75
small_intestine8.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12247_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.32 ± 0.46
Basal Forebrain7.56 ± 0.36
Basal Part of Pons7.52 ± 0.28
Cerebellar Cortex7.49 ± 0.27
Cerebellar Nuclei8.06 ± 0.32
Claustrum7.87 ± 0.38
Epithalamus7.18 ± 0.59
Frontal Lobe7.52 ± 0.44
Globus Pallidus8.09 ± 0.3
Hypothalamus7.76 ± 0.37
Insula7.34 ± 0.21
Limbic Lobe7.57 ± 0.57
Mesencephalon7.48 ± 0.53
Myelencephalon7.54 ± 0.4
Occipital Lobe7.55 ± 0.36
Parietal Lobe7.46 ± 0.42
Pontine Tegmentum7.64 ± 0.29
Striatum6.61 ± 0.5
Subthalamus7.83 ± 0.55
Temporal Lobe7.56 ± 0.32
Thalamus7.41 ± 0.41
White Matter9.47 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gnai1CBCerebellum46.64
96.81
Gnai1CTXCerebral cortex100
100
Gnai1HIPHippocampal region81.29
100
Gnai1HPFHippocampal formation98.96
100
Gnai1HYHypothalamus73.17
71.4
Gnai1LSXLateral septal complex100
100
Gnai1MBMidbrain69.72
74.14
Gnai1MYMedulla67.76
81.08
Gnai1OLFOlfactory bulb100
100
Gnai1PPons58.61
66.06
Gnai1PALPallidum91.97
100
Gnai1RHPRetrohippocampal region100
100
Gnai1sAMYStriatum-like amygdalar nuclei100
100
Gnai1STRStriatum74.94
72.54
Gnai1STRdStriatum dorsal region47.64
42.85
Gnai1STRvStriatum ventral region97.58
81.95
Gnai1THThalamus67.42
68.33
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GNAI1_HUMAN_0 0 0 0 LLLLGAGESGK PRIDE
PAp00001817 16 315 330 DTKEIYTHFTCATDTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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