AutismKB 2.0

Annotation Detail for GNAO1


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Basic Information Top
Gene Symbol:GNAO1 ( DKFZp686O0962,G-ALPHA-o,GNAO )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Band: 16q13
Quick LinksEntrez ID:2775; OMIM: 139311; Uniprot ID:GNAO_HUMAN; ENSEMBL ID: ENSG00000087258; HGNC ID: 4389
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus85 / 564012150
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult62 / 193912131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor20 / 26384575
glioma14 / 106883130
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal259 / 336030777
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain249 / 1100989226
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye20 / 21105494
heart1 / 8962611
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung18 / 33697453
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate6 / 18934531
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis14 / 33044242
thymus2 / 8113124
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204762_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.2
Adipocyte3.35
AdrenalCortex3.45
Adrenalgland2.8
Amygdala326.45
Appendix3.35
AtrioventricularNode2.5
BDCA4+_DentriticCells3.7
Bonemarrow3.25
BronchialEpithelialCells3.35
CD105+_Endothelial3.4
CD14+_Monocytes3.6
CD19+_BCells(neg._sel.)3.6
CD33+_Myeloid4.3
CD34+4.25
CD4+_Tcells3.7
CD56+_NKCells4.05
CD71+_EarlyErythroid3.1
CD8+_Tcells3.3
CardiacMyocytes4.25
Caudatenucleus63.5
Cerebellum137.2
CerebellumPeduncles82.15
CiliaryGanglion2.4
CingulateCortex47.5
Colorectaladenocarcinoma3.35
DorsalRootGanglion2.55
FetalThyroid3.25
Fetalbrain227.05
Fetalliver2.9
Fetallung2.8
GlobusPallidus33.15
Heart4.25
Hypothalamus16.15
Kidney2.65
Leukemia_chronicMyelogenousK-5623.05
Leukemia_promyelocytic-HL-602.95
Leukemialymphoblastic(MOLT-4)2.7
Liver4.35
Lung3.7
Lymphnode2.95
Lymphoma_burkitts(Daudi)4.25
Lymphoma_burkitts(Raji)4.7
MedullaOblongata46.75
OccipitalLobe75.7
OlfactoryBulb2.65
Ovary2.2
Pancreas2.65
PancreaticIslet4.75
ParietalLobe37.55
Pituitary3.9
Placenta3.5
Pons5.4
PrefrontalCortex63.85
Prostate3.95
Salivarygland2.7
SkeletalMuscle3.8
Skin2.7
SmoothMuscle3.8
Spinalcord4.2
SubthalamicNucleus53.4
SuperiorCervicalGanglion4.6
TemporalLobe42.15
Testis2.9
TestisGermCell2.85
TestisIntersitial2.8
TestisLeydigCell3.3
TestisSeminiferousTubule2.9
Thalamus18.35
Thymus2.65
Thyroid4.2
Tongue3.25
Tonsil3.25
Trachea2.8
TrigeminalGanglion3.4
Uterus2.8
UterusCorpus3
WholeBlood3.65
Wholebrain230.15
colon3.4
pineal_day4.4
pineal_night4.26
retina4.125
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P26582
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.34 ± 0.41
Basal Forebrain11.08 ± 0.23
Basal Part of Pons11.44 ± 0.27
Cerebellar Cortex10.92 ± 0.13
Cerebellar Nuclei10.73 ± 0.39
Claustrum12.27 ± 0.29
Epithalamus10.3 ± 0.94
Frontal Lobe11.19 ± 0.36
Globus Pallidus10.03 ± 0.52
Hypothalamus11.24 ± 0.39
Insula11.5 ± 0.29
Limbic Lobe11.32 ± 0.52
Mesencephalon11.08 ± 0.45
Myelencephalon11.1 ± 0.53
Occipital Lobe10.79 ± 0.47
Parietal Lobe11.02 ± 0.39
Pontine Tegmentum11.05 ± 0.42
Striatum11.69 ± 0.26
Subthalamus10.99 ± 0.19
Temporal Lobe11.35 ± 0.36
Thalamus11.16 ± 0.26
White Matter9.82 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gnao1CBCerebellum42.74
72.14
Gnao1CTXCerebral cortex58.56
53.15
Gnao1HIPHippocampal region65.59
72.18
Gnao1HPFHippocampal formation63.64
64.76
Gnao1HYHypothalamus40.63
38.63
Gnao1LSXLateral septal complex36.86
35.33
Gnao1MBMidbrain38.42
37.48
Gnao1MYMedulla38.92
39.95
Gnao1OLFOlfactory bulb63.14
53.1
Gnao1PPons39.1
39.09
Gnao1PALPallidum41.43
41.28
Gnao1RHPRetrohippocampal region61.89
56.38
Gnao1sAMYStriatum-like amygdalar nuclei51.05
45.68
Gnao1STRStriatum57.4
49.45
Gnao1STRdStriatum dorsal region62.65
53.38
Gnao1STRvStriatum ventral region50.68
43.74
Gnao1THThalamus41.36
39.36
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004855 9 250 258 LFDSICNNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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