AutismKB 2.0

Annotation Detail for GNAZ


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Basic Information Top
Gene Symbol:GNAZ ( - )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha z polypeptide
Band: 22q11.22-q11.23
Quick LinksEntrez ID:2781; OMIM: 139160; Uniprot ID:GNAZ_HUMAN; ENSEMBL ID: ENSG00000128266; HGNC ID: 4395
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus44 / 56401278
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult30 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia0 / 972500 
normal127 / 336030737
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer3 / 10268029
retinoblastoma5 / 46356107
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain109 / 110098999
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver2 / 2077439
lung5 / 33697414
lymph0 / 442700 
lymph node1 / 9161010
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204993_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.7
Adipocyte4.65
AdrenalCortex4.85
Adrenalgland4.1
Amygdala18.5
Appendix5.05
AtrioventricularNode3.55
BDCA4+_DentriticCells5.2
Bonemarrow4.7
BronchialEpithelialCells4.65
CD105+_Endothelial4.85
CD14+_Monocytes5.15
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid6
CD34+6.15
CD4+_Tcells5.2
CD56+_NKCells5.6
CD71+_EarlyErythroid22.8
CD8+_Tcells4.55
CardiacMyocytes5.9
Caudatenucleus4.3
Cerebellum8.55
CerebellumPeduncles10.5
CiliaryGanglion3.3
CingulateCortex6.9
Colorectaladenocarcinoma4.75
DorsalRootGanglion3.6
FetalThyroid4.6
Fetalbrain306.85
Fetalliver4.05
Fetallung3.95
GlobusPallidus3.55
Heart5.95
Hypothalamus17.2
Kidney3.75
Leukemia_chronicMyelogenousK-5624.35
Leukemia_promyelocytic-HL-604.15
Leukemialymphoblastic(MOLT-4)3.8
Liver6.2
Lung5.2
Lymphnode4.05
Lymphoma_burkitts(Daudi)6.15
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.75
OccipitalLobe11.35
OlfactoryBulb3.8
Ovary3.15
Pancreas3.8
PancreaticIslet5.1
ParietalLobe6.2
Pituitary5.85
Placenta4.85
Pons4.65
PrefrontalCortex16.8
Prostate5.7
Salivarygland3.75
SkeletalMuscle5.25
Skin3.55
SmoothMuscle5.3
Spinalcord9.35
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.25
TemporalLobe4.4
Testis4.05
TestisGermCell3.9
TestisIntersitial4
TestisLeydigCell4.7
TestisSeminiferousTubule4.1
Thalamus13.2
Thymus3.8
Thyroid5.95
Tongue4.6
Tonsil4.6
Trachea3.95
TrigeminalGanglion4.65
Uterus3.95
UterusCorpus4.25
WholeBlood9.75
Wholebrain53.55
colon4.85
pineal_day6.02
pineal_night5.94
retina34.25
small_intestine4.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11221_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.69 ± 0.22
Basal Forebrain5.55 ± 0.4
Basal Part of Pons5.47 ± 0.37
Cerebellar Cortex5.42 ± 0.32
Cerebellar Nuclei5.35 ± 0.57
Claustrum6 ± 0.42
Epithalamus5.04 ± 0.5
Frontal Lobe5.6 ± 0.42
Globus Pallidus5.23 ± 0.45
Hypothalamus5.38 ± 0.53
Insula5.75 ± 0.3
Limbic Lobe5.95 ± 0.29
Mesencephalon5.54 ± 0.4
Myelencephalon5.61 ± 0.42
Occipital Lobe5.64 ± 0.34
Parietal Lobe5.71 ± 0.46
Pontine Tegmentum5.63 ± 0.6
Striatum5.24 ± 0.48
Subthalamus5.64 ± 0.25
Temporal Lobe5.77 ± 0.33
Thalamus5.52 ± 0.4
White Matter6.02 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GnazCBCerebellum20.09
18.95
GnazCTXCerebral cortex51.21
50.88
GnazHIPHippocampal region39.18
35.54
GnazHPFHippocampal formation46.36
41.85
GnazHYHypothalamus23.15
16.77
GnazLSXLateral septal complex12.75
7.68
GnazMBMidbrain27.38
20.72
GnazMYMedulla33.28
30.81
GnazOLFOlfactory bulb41.26
31.48
GnazPPons31.95
27.39
GnazPALPallidum16.03
13.26
GnazRHPRetrohippocampal region50.5
47.06
GnazsAMYStriatum-like amygdalar nuclei35.81
24.12
GnazSTRStriatum12.48
7.89
GnazSTRdStriatum dorsal region6.21
3.99
GnazSTRvStriatum ventral region19.9
10.87
GnazTHThalamus20.21
13.73
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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