AutismKB 2.0

Annotation Detail for GNB2


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Basic Information Top
Gene Symbol:GNB2 ( - )
Gene Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 2
Band: 7q22.1
Quick LinksEntrez ID:2783; OMIM: 139390; Uniprot ID:GBB2_HUMAN; ENSEMBL ID: ENSG00000172354; HGNC ID: 4398
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst8 / 62319128
fetus87 / 564012154
neonate1 / 3109732
infant0 / 236200 
juvenile8 / 55556143
adult354 / 1939121182
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor5 / 12794390
bladder carcinoma11 / 17475629
breast (mammary gland) tumor32 / 94178339
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor21 / 114246183
esophageal tumor1 / 1729057
gastrointestinal tumor33 / 119369276
germ cell tumor22 / 26384583
glioma48 / 106883449
head and neck tumor62 / 136302454
kidney tumor24 / 68959348
leukemia33 / 95842344
liver tumor15 / 96359155
lung tumor40 / 103127387
lymphoma54 / 71755752
non-neoplasia15 / 97250154
normal376 / 3360307111
ovarian tumor9 / 76682117
pancreatic tumor51 / 104616487
primitive neuroectodermal tumor of the CNS34 / 125680270
prostate cancer27 / 102680262
retinoblastoma7 / 46356151
skin tumor26 / 124949208
soft tissue/muscle tissue tumor13 / 125191103
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland6 / 33197180
ascites16 / 40015399
bladder9 / 29757302
blood44 / 123478356
bone14 / 71655195
bone marrow2 / 4880140
brain126 / 1100989114
cervix4 / 4817183
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue31 / 215722143
esophagus1 / 2020949
eye32 / 211054151
heart11 / 89626122
intestine46 / 234472196
kidney31 / 211777146
larynx3 / 24145124
liver15 / 20774372
lung98 / 336974290
lymph48 / 442701084
lymph node17 / 91610185
mammary gland44 / 153271287
mouth4 / 6705259
muscle8 / 10771574
nerve3 / 15768190
ovary15 / 102051146
pancreas71 / 214812330
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland4 / 16585241
placenta34 / 280825121
prostate35 / 189345184
salivary gland51 / 201552530
skin34 / 210574161
spleen2 / 5395237
stomach18 / 96619186
testis10 / 33044230
thymus3 / 8113136
thyroid7 / 47473147
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus28 / 232878120
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200852_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts425.7
Adipocyte196.2
AdrenalCortex176.2
Adrenalgland174.1
Amygdala310.7
Appendix82.25
AtrioventricularNode59.25
BDCA4+_DentriticCells320.05
Bonemarrow211.5
BronchialEpithelialCells375.65
CD105+_Endothelial289.35
CD14+_Monocytes543.5
CD19+_BCells(neg._sel.)296.8
CD33+_Myeloid568.5
CD34+306.1
CD4+_Tcells232.1
CD56+_NKCells459.5
CD71+_EarlyErythroid287.1
CD8+_Tcells198.55
CardiacMyocytes393.1
Caudatenucleus193.8
Cerebellum153
CerebellumPeduncles194.15
CiliaryGanglion76.6
CingulateCortex119.35
Colorectaladenocarcinoma566.85
DorsalRootGanglion77.55
FetalThyroid216.9
Fetalbrain304.65
Fetalliver150.1
Fetallung275.1
GlobusPallidus91.75
Heart372.05
Hypothalamus169.3
Kidney155.35
Leukemia_chronicMyelogenousK-562180.7
Leukemia_promyelocytic-HL-60172.6
Leukemialymphoblastic(MOLT-4)235.3
Liver356.4
Lung795.05
Lymphnode168.6
Lymphoma_burkitts(Daudi)129
Lymphoma_burkitts(Raji)525.7
MedullaOblongata120.1
OccipitalLobe136.25
OlfactoryBulb100.75
Ovary150.5
Pancreas157.4
PancreaticIslet237.2
ParietalLobe129.35
Pituitary271.85
Placenta353.6
Pons141.1
PrefrontalCortex325.85
Prostate700.9
Salivarygland24.9
SkeletalMuscle107.7
Skin35
SmoothMuscle435.65
Spinalcord199.5
SubthalamicNucleus116.9
SuperiorCervicalGanglion41.65
TemporalLobe160.4
Testis139.65
TestisGermCell183.2
TestisIntersitial113.45
TestisLeydigCell163.45
TestisSeminiferousTubule122.9
Thalamus99.6
Thymus227.85
Thyroid616.6
Tongue191.45
Tonsil217.05
Trachea167.2
TrigeminalGanglion65.35
Uterus230.25
UterusCorpus134.1
WholeBlood1043.05
Wholebrain225
colon166.05
pineal_day107.28
pineal_night104.04
retina220.25
small_intestine121.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6535_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.56 ± 0.43
Basal Forebrain8.26 ± 0.26
Basal Part of Pons8.18 ± 0.25
Cerebellar Cortex7.95 ± 0.3
Cerebellar Nuclei7.73 ± 0.23
Claustrum8.64 ± 0.37
Epithalamus8.08 ± 0.3
Frontal Lobe8.22 ± 0.35
Globus Pallidus8.16 ± 0.16
Hypothalamus8.17 ± 0.2
Insula8.18 ± 0.27
Limbic Lobe8.44 ± 0.3
Mesencephalon8.12 ± 0.45
Myelencephalon8.23 ± 0.37
Occipital Lobe7.83 ± 0.25
Parietal Lobe8.08 ± 0.39
Pontine Tegmentum8.11 ± 0.31
Striatum8.67 ± 0.33
Subthalamus7.74 ± 0.29
Temporal Lobe8.26 ± 0.33
Thalamus8.08 ± 0.31
White Matter7.79 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gnb2CBCerebellum100
88.65
Gnb2CTXCerebral cortex100
100
Gnb2HIPHippocampal region100
100
Gnb2HPFHippocampal formation100
100
Gnb2HYHypothalamus100
100
Gnb2LSXLateral septal complex100
100
Gnb2MBMidbrain100
100
Gnb2MYMedulla100
100
Gnb2OLFOlfactory bulb100
100
Gnb2PPons100
100
Gnb2PALPallidum100
100
Gnb2RHPRetrohippocampal region100
100
Gnb2sAMYStriatum-like amygdalar nuclei100
100
Gnb2STRStriatum100
100
Gnb2STRdStriatum dorsal region100
100
Gnb2STRvStriatum ventral region100
100
Gnb2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GBB2_HUMAN_0 0 0 0 LIIWDSYTTNK PRIDE
GBB2_HUMAN_0 0 0 0 LIIWDSYTTNKVHAIPLR PRIDE
GBB2_HUMAN_0 0 0 0 TFVSGACDASIK PRIDE
GBB2_HUMAN_1 7 1 7 SELEQLR PRIDE
GBB2_HUMAN_137 13 137 149 ELPGHTGYLSCCR PRIDE
GBB2_HUMAN_197 12 197 208 TFVSGACDASIK PRIDE
GBB2_HUMAN_2 7 2 8 SELEQLR PRIDE
GBB2_HUMAN_22 20 22 41 KACGDSTLTQITAGLDPVGR PRIDE
GBB2_HUMAN_283 21 283 303 LLLAGYDDFNCNIWDAMKGDR PRIDE
GBB2_HUMAN_57 11 57 67 IYAMHWGTDSR PRIDE
GBB2_HUMAN_68 10 68 77 LLVSASQDGK PRIDE
GBB2_HUMAN_78 11 78 88 LIIWDSYTTNK PRIDE
GBB2_HUMAN_78 18 78 95 LIIWDSYTTNKVHAIPLR PRIDE
PAp00000210 19 24 42 ACGDSTLTQITAGLDPVGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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