AutismKB 2.0

Annotation Detail for SFN


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Basic Information Top
Gene Symbol:SFN ( YWHAS )
Gene Full Name: stratifin
Band: 1p36.11
Quick LinksEntrez ID:2810; OMIM: 601290; Uniprot ID:1433S_HUMAN; ENSEMBL ID: ENSG00000175793; HGNC ID: 10773
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body17 / 70761240
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult124 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor1 / 9417810
cervical tumor6 / 34366174
chondrosarcoma7 / 8282384
colorectal tumor13 / 114246113
esophageal tumor9 / 17290520
gastrointestinal tumor19 / 119369159
germ cell tumor11 / 26384541
glioma60 / 106883561
head and neck tumor31 / 136302227
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor31 / 103127300
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal91 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor29 / 104616277
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer17 / 102680165
retinoblastoma0 / 463560 
skin tumor37 / 124949296
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites6 / 40015149
bladder3 / 29757100
blood1 / 1234788
bone7 / 7165597
bone marrow0 / 488010 
brain66 / 110098959
cervix8 / 48171166
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus9 / 20209445
eye15 / 21105471
heart4 / 8962644
intestine25 / 234472106
kidney5 / 21177723
larynx7 / 24145289
liver2 / 2077439
lung48 / 336974142
lymph0 / 442700 
lymph node5 / 9161054
mammary gland4 / 15327126
mouth16 / 67052238
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas32 / 214812148
parathyroid0 / 205390 
pharynx7 / 41328169
pituitary gland0 / 165850 
placenta12 / 28082542
prostate25 / 189345132
salivary gland0 / 201550 
skin53 / 210574251
spleen0 / 539520 
stomach8 / 9661982
testis0 / 3304420 
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus12 / 23287851
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209260_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.1
Adipocyte9.2
AdrenalCortex9.05
Adrenalgland7.4
Amygdala8.65
Appendix8.2
AtrioventricularNode5.5
BDCA4+_DentriticCells8.35
Bonemarrow8.1
BronchialEpithelialCells1158.9
CD105+_Endothelial7.2
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)7.6
CD33+_Myeloid9.25
CD34+10.15
CD4+_Tcells8.1
CD56+_NKCells8.8
CD71+_EarlyErythroid7.4
CD8+_Tcells6.15
CardiacMyocytes9.9
Caudatenucleus7.3
Cerebellum6.6
CerebellumPeduncles9.2
CiliaryGanglion5.85
CingulateCortex8.15
Colorectaladenocarcinoma40.2
DorsalRootGanglion6.3
FetalThyroid7.7
Fetalbrain7.3
Fetalliver8.65
Fetallung7.85
GlobusPallidus6.35
Heart20.55
Hypothalamus8.35
Kidney6.6
Leukemia_chronicMyelogenousK-5628.5
Leukemia_promyelocytic-HL-6010.3
Leukemialymphoblastic(MOLT-4)7.2
Liver16.05
Lung41.8
Lymphnode7.15
Lymphoma_burkitts(Daudi)9.15
Lymphoma_burkitts(Raji)13.5
MedullaOblongata7.3
OccipitalLobe7.4
OlfactoryBulb8.35
Ovary5.35
Pancreas19.5
PancreaticIslet10.3
ParietalLobe8.5
Pituitary9.65
Placenta10.85
Pons7.75
PrefrontalCortex9.3
Prostate73.5
Salivarygland6.5
SkeletalMuscle15
Skin79.5
SmoothMuscle9.35
Spinalcord8.3
SubthalamicNucleus7.25
SuperiorCervicalGanglion9.1
TemporalLobe7.45
Testis8.55
TestisGermCell6.7
TestisIntersitial6.7
TestisLeydigCell8
TestisSeminiferousTubule7.05
Thalamus7.8
Thymus6.95
Thyroid10.45
Tongue392.9
Tonsil125.1
Trachea26.7
TrigeminalGanglion9.3
Uterus6.8
UterusCorpus7.1
WholeBlood9.1
Wholebrain7.1
colon19
pineal_day9.66
pineal_night8.94
retina9.95
small_intestine14.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P63254
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.5 ± 0.6
Basal Forebrain7.27 ± 0.44
Basal Part of Pons7.38 ± 0.67
Cerebellar Cortex6.89 ± 0.52
Cerebellar Nuclei7.39 ± 0.48
Claustrum7.88 ± 0.73
Epithalamus6.89 ± 0.59
Frontal Lobe7.28 ± 0.75
Globus Pallidus8 ± 0.22
Hypothalamus6.92 ± 0.61
Insula7.03 ± 0.74
Limbic Lobe7.54 ± 0.74
Mesencephalon7.47 ± 0.54
Myelencephalon7.41 ± 0.7
Occipital Lobe7.45 ± 0.74
Parietal Lobe7.25 ± 0.58
Pontine Tegmentum7.1 ± 0.48
Striatum7.47 ± 0.7
Subthalamus6.67 ± 0.57
Temporal Lobe7.24 ± 0.67
Thalamus7.36 ± 0.61
White Matter7.68 ± 0.48
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
SfnCBCerebellum27.45
42.43
SfnCTXCerebral cortex46.69
33.56
SfnHIPHippocampal region56.23
55.25
SfnHPFHippocampal formation50.81
45.93
SfnHYHypothalamus38.65
27.79
SfnLSXLateral septal complex13.42
7.82
SfnMBMidbrain29.37
26.39
SfnMYMedulla47.95
52.33
SfnOLFOlfactory bulb59.8
38.84
SfnPPons38.13
39.53
SfnPALPallidum24.13
20.02
SfnRHPRetrohippocampal region40.61
31.52
SfnsAMYStriatum-like amygdalar nuclei19.43
11.82
SfnSTRStriatum9.52
5.67
SfnSTRdStriatum dorsal region4.26
2.9
SfnSTRvStriatum ventral region22.2
10.88
SfnTHThalamus32.16
26.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
1433S_HUMAN_108 10 108 117 IKEAGDAESR PRIDE
1433S_HUMAN_11 16 11 26 LAEQAERYEDMAAFMK PRIDE
1433S_HUMAN_122 7 122 128 MKGDYYR PRIDE
1433S_HUMAN_129 11 129 139 YLAEVATGDDK PRIDE
1433S_HUMAN_148 11 148 158 SAYQEAMDISK PRIDE
1433S_HUMAN_148 12 148 159 SAYQEAMDISKK PRIDE
1433S_HUMAN_160 9 160 168 EMPPTNPIR PRIDE
1433S_HUMAN_169 26 169 194 LGLALNFSVFHYEIANSPEEAISLAK PRIDE
1433S_HUMAN_18 9 18 26 YEDMAAFMK PRIDE
1433S_HUMAN_195 19 195 213 TTFDEAMADLHTLSEDSYK PRIDE
1433S_HUMAN_195 29 195 223 TTFDEAMADLHTLSEDSYKDSTLIMQLLR PRIDE
1433S_HUMAN_214 10 214 223 DSTLIMQLLR PRIDE
1433S_HUMAN_27 14 27 40 GAVEKGEELSCEER PRIDE
1433S_HUMAN_27 22 27 48 GAVEKGEELSCEERNLLSVAYK PRIDE
1433S_HUMAN_41 8 41 48 NLLSVAYK PRIDE
1433S_HUMAN_60 22 60 81 VLSSIEQKSNEEGSEEKGPEVR PRIDE
1433S_HUMAN_60 8 60 67 VLSSIEQK PRIDE
1433S_HUMAN_68 14 68 81 SNEEGSEEKGPEVR PRIDE
1433S_HUMAN_82 27 82 108 EYREKVETELQGVCDTVLGLLDSHLIK PRIDE
1433S_HUMAN_85 24 85 108 EKVETELQGVCDTVLGLLDSHLIK PRIDE
1433S_HUMAN_85 32 85 116 EKVETELQGVCDTVLGLLDSHLIKEAGDAESR PRIDE
1433S_HUMAN_87 30 87 116 VETELQGVCDTVLGLLDSHLIKEAGDAESR PRIDE
1433S_HUMAN_9 18 9 26 AKLAEQAERYEDMAAFMK PRIDE
PAp00002677 14 28 41 GAVEKGEELSCEER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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