AutismKB 2.0

Annotation Detail for PPP2R3B


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Basic Information Top
Gene Symbol:PPP2R3B ( FLJ60425,NYREN8,PPP2R3L,PPP2R3LY,PR48 )
Gene Full Name: protein phosphatase 2, regulatory subunit B'', beta
Band: Xp22.3 and Yp11.3
Quick LinksEntrez ID:28227; OMIM: 300339; Uniprot ID:P2R3B_HUMAN; ENSEMBL ID: ENSG00000167393; HGNC ID: 13417
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus13 / 56401223
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult30 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma6 / 10688356
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal61 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor1 / 1249498
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow0 / 488010 
brain21 / 110098919
cervix4 / 4817183
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye11 / 21105452
heart0 / 896260 
intestine0 / 2344720 
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung1 / 3369742
lymph0 / 442700 
lymph node3 / 9161032
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach0 / 966190 
testis4 / 33044212
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219264_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.6
Adipocyte4.25
AdrenalCortex4.7
Adrenalgland3.6
Amygdala4.55
Appendix4.35
AtrioventricularNode3.55
BDCA4+_DentriticCells4.85
Bonemarrow4.3
BronchialEpithelialCells4.3
CD105+_Endothelial4.4
CD14+_Monocytes4.65
CD19+_BCells(neg._sel.)4.65
CD33+_Myeloid5.65
CD34+6.6
CD4+_Tcells4.75
CD56+_NKCells5.2
CD71+_EarlyErythroid4
CD8+_Tcells4.3
CardiacMyocytes5.8
Caudatenucleus3.9
Cerebellum3.55
CerebellumPeduncles5.05
CiliaryGanglion3.1
CingulateCortex4.5
Colorectaladenocarcinoma4.45
DorsalRootGanglion3.35
FetalThyroid4.2
Fetalbrain4.3
Fetalliver3.8
Fetallung3.5
GlobusPallidus3.3
Heart95.25
Hypothalamus4.75
Kidney3.55
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-603.85
Leukemialymphoblastic(MOLT-4)6.7
Liver7.55
Lung4.8
Lymphnode3.7
Lymphoma_burkitts(Daudi)6.2
Lymphoma_burkitts(Raji)6.35
MedullaOblongata3.95
OccipitalLobe3.85
OlfactoryBulb3.45
Ovary2.9
Pancreas3.5
PancreaticIslet4.65
ParietalLobe4.6
Pituitary5.4
Placenta4.45
Pons4.1
PrefrontalCortex5.4
Prostate5.05
Salivarygland3.5
SkeletalMuscle5.3
Skin3.4
SmoothMuscle4.95
Spinalcord4.65
SubthalamicNucleus4
SuperiorCervicalGanglion5.05
TemporalLobe4
Testis4.05
TestisGermCell6.85
TestisIntersitial3.9
TestisLeydigCell4.35
TestisSeminiferousTubule3.75
Thalamus4.45
Thymus3.45
Thyroid5.45
Tongue5.3
Tonsil4.25
Trachea3.65
TrigeminalGanglion4.5
Uterus3.55
UterusCorpus4
WholeBlood4.7
Wholebrain3.7
colon4.4
pineal_day5.42
pineal_night5.36
retina5.25
small_intestine4.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5773_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.1 ± 0.59
Basal Forebrain7.33 ± 0.36
Basal Part of Pons6.57 ± 0.44
Cerebellar Cortex6.59 ± 0.14
Cerebellar Nuclei7.06 ± 0.39
Claustrum7.4 ± 0.4
Epithalamus7.32 ± 0.39
Frontal Lobe6.59 ± 0.51
Globus Pallidus8.09 ± 0.2
Hypothalamus7.16 ± 0.32
Insula6.63 ± 0.34
Limbic Lobe6.69 ± 0.57
Mesencephalon7.12 ± 0.45
Myelencephalon6.87 ± 0.5
Occipital Lobe6.9 ± 0.43
Parietal Lobe6.7 ± 0.54
Pontine Tegmentum6.85 ± 0.44
Striatum7.1 ± 0.44
Subthalamus6.66 ± 0.31
Temporal Lobe6.77 ± 0.42
Thalamus6.76 ± 0.33
White Matter8.48 ± 0.65
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
P2R3B_HUMAN_320 10 320 329 EQKEQISLLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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