AutismKB 2.0

Annotation Detail for NPBWR2


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Basic Information Top
Gene Symbol:NPBWR2 ( GPR8 )
Gene Full Name: neuropeptides B/W receptor 2
Band: 20q13.33
Quick LinksEntrez ID:2832; OMIM: 600731; Uniprot ID:NPBW2_HUMAN; ENSEMBL ID: ENSG00000125522; HGNC ID: 4530
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221358_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.5
Adipocyte3.4
AdrenalCortex3.8
Adrenalgland3
Amygdala3.6
Appendix3.5
AtrioventricularNode2.65
BDCA4+_DentriticCells3.8
Bonemarrow3.4
BronchialEpithelialCells3.45
CD105+_Endothelial3.55
CD14+_Monocytes3.7
CD19+_BCells(neg._sel.)3.65
CD33+_Myeloid4.5
CD34+4.4
CD4+_Tcells3.8
CD56+_NKCells4.15
CD71+_EarlyErythroid3.25
CD8+_Tcells3.35
CardiacMyocytes4.45
Caudatenucleus3.1
Cerebellum2.85
CerebellumPeduncles4
CiliaryGanglion2.5
CingulateCortex3.55
Colorectaladenocarcinoma3.45
DorsalRootGanglion2.65
FetalThyroid3.35
Fetalbrain3.45
Fetalliver3
Fetallung2.85
GlobusPallidus2.6
Heart4.4
Hypothalamus3.75
Kidney2.85
Leukemia_chronicMyelogenousK-5623.15
Leukemia_promyelocytic-HL-603.1
Leukemialymphoblastic(MOLT-4)2.8
Liver4.55
Lung3.8
Lymphnode2.95
Lymphoma_burkitts(Daudi)4.45
Lymphoma_burkitts(Raji)4.9
MedullaOblongata3.2
OccipitalLobe3.1
OlfactoryBulb2.75
Ovary2.25
Pancreas2.8
PancreaticIslet3.7
ParietalLobe3.75
Pituitary4.05
Placenta3.6
Pons3.3
PrefrontalCortex4.35
Prostate4
Salivarygland2.8
SkeletalMuscle4.2
Skin2.75
SmoothMuscle3.9
Spinalcord3.7
SubthalamicNucleus3.2
SuperiorCervicalGanglion4.2
TemporalLobe3.2
Testis3
TestisGermCell2.9
TestisIntersitial2.9
TestisLeydigCell3.45
TestisSeminiferousTubule2.95
Thalamus3.55
Thymus2.7
Thyroid4.35
Tongue3.45
Tonsil3.4
Trachea2.9
TrigeminalGanglion3.55
Uterus2.85
UterusCorpus3.2
WholeBlood3.8
Wholebrain3
colon3.5
pineal_day4.34
pineal_night4.26
retina4.225
small_intestine3.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P40334
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.56 ± 0.85
Basal Forebrain3.12 ± 0.43
Basal Part of Pons2.85 ± 0.56
Cerebellar Cortex2.73 ± 0.78
Cerebellar Nuclei3.64 ± 0.65
Claustrum3.68 ± 0.76
Epithalamus2.53 ± 0.58
Frontal Lobe3.09 ± 1
Globus Pallidus4.01 ± 0.53
Hypothalamus2.97 ± 0.73
Insula2.94 ± 0.86
Limbic Lobe3.17 ± 0.74
Mesencephalon3.17 ± 0.89
Myelencephalon3.18 ± 0.77
Occipital Lobe3.24 ± 0.58
Parietal Lobe3.28 ± 0.79
Pontine Tegmentum3.2 ± 0.77
Striatum3.42 ± 0.72
Subthalamus3.48 ± 0.12
Temporal Lobe2.9 ± 0.77
Thalamus3.14 ± 0.76
White Matter2.9 ± 0.43
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018