AutismKB 2.0

Annotation Detail for TSEN54


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Basic Information Top
Gene Symbol:TSEN54 ( FLJ37147,PCH2A,PCH4,SEN54L,sen54 )
Gene Full Name: tRNA splicing endonuclease 54 homolog (S. cerevisiae)
Band: 17q25.1
Quick LinksEntrez ID:283989; OMIM: 608755; Uniprot ID:SEN54_HUMAN; ENSEMBL ID: ENSG00000182173; HGNC ID: 27561
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile5 / 5555689
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor12 / 26384545
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor1 / 9635910
lung tumor11 / 103127106
lymphoma7 / 7175597
non-neoplasia0 / 972500 
normal74 / 336030722
ovarian tumor1 / 7668213
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor10 / 12494980
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood11 / 12347889
bone2 / 7165527
bone marrow0 / 488010 
brain18 / 110098916
cervix5 / 48171103
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye4 / 21105418
heart1 / 8962611
intestine7 / 23447229
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung18 / 33697453
lymph3 / 4427067
lymph node6 / 9161065
mammary gland1 / 1532716
mouth0 / 670520 
muscle10 / 10771592
nerve1 / 1576863
ovary3 / 10205129
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate5 / 18934526
salivary gland0 / 201550 
skin11 / 21057452
spleen1 / 5395218
stomach12 / 96619124
testis3 / 3304429
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11283_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.72 ± 0.53
Basal Forebrain5.67 ± 0.29
Basal Part of Pons5.48 ± 0.47
Cerebellar Cortex5.96 ± 0.24
Cerebellar Nuclei6.2 ± 0.42
Claustrum5.55 ± 0.5
Epithalamus5.41 ± 0.38
Frontal Lobe5.27 ± 0.46
Globus Pallidus6.27 ± 0.66
Hypothalamus4.99 ± 0.35
Insula5.15 ± 0.48
Limbic Lobe5.4 ± 0.55
Mesencephalon5.58 ± 0.54
Myelencephalon5.52 ± 0.53
Occipital Lobe5.85 ± 0.51
Parietal Lobe5.47 ± 0.42
Pontine Tegmentum5.5 ± 0.45
Striatum5.45 ± 0.52
Subthalamus5.67 ± 0.33
Temporal Lobe5.45 ± 0.39
Thalamus5.56 ± 0.37
White Matter6.75 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tsen54PPons8.24
8.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
SEN54_HUMAN_1 16 1 16 MEPDPEPAAVEVPAGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018