Annotation Detail for NEK8
Basic Information Top
| Gene Symbol: | NEK8 ( JCK,MGC138445,NEK12A,NPHP9 ) |
|---|---|
| Gene Full Name: | NIMA (never in mitosis gene a)- related kinase 8 |
| Band: | 17q11.1 |
| Quick Links | Entrez ID:284086; OMIM: 609799; Uniprot ID:NEK8_HUMAN; ENSEMBL ID: ENSG00000160602; HGNC ID: 13387 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.448468
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 0 / 564012 | 0 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 9 / 1939121 | 4 |  |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 1 / 114246 | 8 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 2 / 263845 | 7 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 1 / 103127 | 9 | |
| lymphoma | 2 / 71755 | 27 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 11 / 3360307 | 3 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 2 / 46356 | 43 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 1 / 123478 | 8 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 1 / 1100989 | 0 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 2 / 149255 | 13 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 3 / 215722 | 13 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 3 / 211054 | 14 | |
| heart | 0 / 89626 | 0 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 1 / 211777 | 4 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 1 / 336974 | 2 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 1 / 91610 | 10 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 3 / 214812 | 13 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 3 / 280825 | 10 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 2 / 210574 | 9 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 1 / 330442 | 3 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 2 / 16999 | 117 |  |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 1 / 232878 | 4 | |
| vascular | 0 / 51780 | 0 |
Microarray in - Probe name: A_23_P152873
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.77 ± 0.54 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.56 ± 0.35 | |
| Basal Part of Pons | 4.45 ± 0.43 | |
| Cerebellar Cortex | 4.63 ± 0.43 | |
| Cerebellar Nuclei | 4.6 ± 0.72 | |
| Claustrum | 4.94 ± 0.79 | |
| Epithalamus | 4.12 ± 0.44 | |
| Frontal Lobe | 4.35 ± 0.5 | |
| Globus Pallidus | 4.56 ± 0.76 | |
| Hypothalamus | 4.23 ± 0.52 | |
| Insula | 4.29 ± 0.38 | |
| Limbic Lobe | 4.41 ± 0.5 | |
| Mesencephalon | 4.59 ± 0.61 | |
| Myelencephalon | 4.5 ± 0.55 | |
| Occipital Lobe | 4.71 ± 0.53 | |
| Parietal Lobe | 4.47 ± 0.47 | |
| Pontine Tegmentum | 4.3 ± 0.59 | |
| Striatum | 4.35 ± 0.53 | |
| Subthalamus | 4.64 ± 0.32 | |
| Temporal Lobe | 4.34 ± 0.58 | |
| Thalamus | 4.47 ± 0.46 | |
| White Matter | 5.19 ± 0.11 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Nek8 | CB | Cerebellum | 1.46 | |
| 2.2 | | |||
| Nek8 | CTX | Cerebral cortex | 0.47 | |
| 0.72 | | |||
| Nek8 | HIP | Hippocampal region | 0.92 | |
| 1.4 | | |||
| Nek8 | HPF | Hippocampal formation | 1 | |
| 1.46 | | |||
| Nek8 | HY | Hypothalamus | 0.1 | |
| 0.1 | | |||
| Nek8 | LSX | Lateral septal complex | 0.1 | |
| 0.22 | | |||
| Nek8 | MB | Midbrain | 0.49 | |
| 0.69 | | |||
| Nek8 | MY | Medulla | 0.4 | |
| 0.43 | | |||
| Nek8 | OLF | Olfactory bulb | 1.55 | |
| 2.93 | | |||
| Nek8 | P | Pons | 6.11 | |
| 8.38 | | |||
| Nek8 | PAL | Pallidum | 0.06 | |
| 0.05 | | |||
| Nek8 | RHP | Retrohippocampal region | 1.17 | |
| 1.58 | | |||
| Nek8 | sAMY | Striatum-like amygdalar nuclei | 0.11 | |
| 0.24 | | |||
| Nek8 | STR | Striatum | 0.09 | |
| 0.1 | | |||
| Nek8 | STRd | Striatum dorsal region | 0.09 | |
| 0.08 | | |||
| Nek8 | STRv | Striatum ventral region | 0.06 | |
| 0.04 | | |||
| Nek8 | TH | Thalamus | 0.28 | |
| 0.34 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00615927 | 7 | 377 | 383 | QPQFISR | Peptide Atlas |