AutismKB 2.0

Annotation Detail for ANGPT2


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Basic Information Top
Gene Symbol:ANGPT2 ( AGPT2,ANG2 )
Gene Full Name: angiopoietin 2
Band: 8p23.1
Quick LinksEntrez ID:285; OMIM: 601922; Uniprot ID:ANGP2_HUMAN; ENSEMBL ID: ENSG00000091879; HGNC ID: 485
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus16 / 56401228
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult85 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal111 / 336030733
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow2 / 4880140
brain27 / 110098924
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine4 / 23447217
kidney6 / 21177728
larynx3 / 24145124
liver3 / 20774314
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland10 / 15327165
mouth3 / 6705244
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta40 / 280825142
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach5 / 9661951
testis1 / 3304423
thymus6 / 8113173
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord3 / 13680219
uterus17 / 23287872
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205572_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.15
Adipocyte6.3
AdrenalCortex7.8
Adrenalgland5.85
Amygdala6.5
Appendix7.5
AtrioventricularNode6.25
BDCA4+_DentriticCells6.35
Bonemarrow6.9
BronchialEpithelialCells6.3
CD105+_Endothelial6.4
CD14+_Monocytes6.8
CD19+_BCells(neg._sel.)6.6
CD33+_Myeloid7.8
CD34+7.85
CD4+_Tcells6.5
CD56+_NKCells7.35
CD71+_EarlyErythroid6.15
CD8+_Tcells5.8
CardiacMyocytes11.4
Caudatenucleus5.85
Cerebellum5.3
CerebellumPeduncles7.75
CiliaryGanglion9.7
CingulateCortex6.85
Colorectaladenocarcinoma6.5
DorsalRootGanglion5.55
FetalThyroid8.6
Fetalbrain6.5
Fetalliver5.8
Fetallung6.2
GlobusPallidus5.05
Heart9.6
Hypothalamus6.7
Kidney6.35
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.75
Leukemialymphoblastic(MOLT-4)4.95
Liver9.9
Lung7.05
Lymphnode5.65
Lymphoma_burkitts(Daudi)8.45
Lymphoma_burkitts(Raji)9.65
MedullaOblongata5.9
OccipitalLobe5.8
OlfactoryBulb5.4
Ovary4.8
Pancreas5.65
PancreaticIslet7
ParietalLobe7.3
Pituitary7.55
Placenta7.75
Pons6.45
PrefrontalCortex7.85
Prostate7.45
Salivarygland5.35
SkeletalMuscle9.25
Skin5.65
SmoothMuscle7.3
Spinalcord7
SubthalamicNucleus7.65
SuperiorCervicalGanglion9.5
TemporalLobe6.15
Testis5.6
TestisGermCell6.2
TestisIntersitial5.5
TestisLeydigCell7.05
TestisSeminiferousTubule5.6
Thalamus6.8
Thymus5
Thyroid8.15
Tongue7
Tonsil6.45
Trachea5.4
TrigeminalGanglion7.95
Uterus5.2
UterusCorpus6.35
WholeBlood7.05
Wholebrain5.15
colon6.5
pineal_day7.94
pineal_night7.8
retina8.6
small_intestine6.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P60079
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.51 ± 0.75
Basal Forebrain4.52 ± 0.31
Basal Part of Pons5.11 ± 0.39
Cerebellar Cortex4.32 ± 0.29
Cerebellar Nuclei5.01 ± 0.79
Claustrum4.86 ± 0.78
Epithalamus5.52 ± 0.67
Frontal Lobe4.52 ± 0.53
Globus Pallidus5.63 ± 0.54
Hypothalamus4.37 ± 0.73
Insula4.39 ± 0.44
Limbic Lobe4.5 ± 0.57
Mesencephalon4.44 ± 0.63
Myelencephalon4.67 ± 0.69
Occipital Lobe4.63 ± 0.82
Parietal Lobe4.21 ± 0.65
Pontine Tegmentum4.71 ± 0.71
Striatum6.07 ± 0.59
Subthalamus3.7 ± 0.21
Temporal Lobe4.49 ± 0.44
Thalamus4.86 ± 0.74
White Matter4.9 ± 0.59
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Angpt2CBCerebellum3.11
4.14
Angpt2CTXCerebral cortex8.59
6.3
Angpt2HIPHippocampal region7.44
8.66
Angpt2HPFHippocampal formation6.9
7.04
Angpt2HYHypothalamus2.16
2.19
Angpt2LSXLateral septal complex0.23
0.16
Angpt2MBMidbrain2.6
3.54
Angpt2MYMedulla2.49
3.62
Angpt2OLFOlfactory bulb10.25
7.9
Angpt2PPons5.18
8.37
Angpt2PALPallidum0.98
0.93
Angpt2RHPRetrohippocampal region5.44
4.26
Angpt2sAMYStriatum-like amygdalar nuclei6.89
4.66
Angpt2STRStriatum2.06
1.55
Angpt2STRdStriatum dorsal region1.25
0.96
Angpt2STRvStriatum ventral region3.53
2.54
Angpt2THThalamus8.7
9.01
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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