AutismKB 2.0

Annotation Detail for NKIRAS2


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Basic Information Top
Gene Symbol:NKIRAS2 ( DKFZp434N1526,KBRAS2,MGC74742,kappaB-Ras2 )
Gene Full Name: NFKB inhibitor interacting Ras-like 2
Band: 17q21.2
Quick LinksEntrez ID:28511; OMIM: 604497; Uniprot ID:KBRS2_HUMAN; ENSEMBL ID: ENSG00000168256; HGNC ID: 17898
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst3 / 6231948
fetus44 / 56401278
neonate2 / 3109764
infant7 / 23620296
juvenile7 / 55556125
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor6 / 34366174
chondrosarcoma5 / 8282360
colorectal tumor9 / 11424678
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor27 / 263845102
glioma10 / 10688393
head and neck tumor12 / 13630288
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor8 / 9635983
lung tumor11 / 103127106
lymphoma4 / 7175555
non-neoplasia0 / 972500 
normal227 / 336030767
ovarian tumor4 / 7668252
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS28 / 125680222
prostate cancer6 / 10268058
retinoblastoma15 / 46356323
skin tumor22 / 124949176
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood6 / 12347848
bone3 / 7165541
bone marrow4 / 4880181
brain68 / 110098961
cervix6 / 48171124
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus1 / 2020949
eye31 / 211054146
heart12 / 89626133
intestine15 / 23447263
kidney21 / 21177799
larynx3 / 24145124
liver10 / 20774348
lung25 / 33697474
lymph0 / 442700 
lymph node5 / 9161054
mammary gland5 / 15327132
mouth7 / 67052104
muscle3 / 10771527
nerve0 / 157680 
ovary11 / 102051107
pancreas16 / 21481274
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta37 / 280825131
prostate14 / 18934573
salivary gland1 / 2015549
skin26 / 210574123
spleen4 / 5395274
stomach3 / 9661931
testis13 / 33044239
thymus7 / 8113186
thyroid2 / 4747342
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord1 / 1368073
uterus12 / 23287851
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218240_at
Cell line Expression level Expression bar
721_B_lymphoblasts66.3
Adipocyte41.65
AdrenalCortex32.15
Adrenalgland26.35
Amygdala31.9
Appendix31.3
AtrioventricularNode22.3
BDCA4+_DentriticCells61.8
Bonemarrow29.85
BronchialEpithelialCells42.4
CD105+_Endothelial30.1
CD14+_Monocytes236.45
CD19+_BCells(neg._sel.)32.6
CD33+_Myeloid77.35
CD34+37.7
CD4+_Tcells30.55
CD56+_NKCells38.6
CD71+_EarlyErythroid28.3
CD8+_Tcells25.7
CardiacMyocytes54.25
Caudatenucleus26.85
Cerebellum24.4
CerebellumPeduncles41.9
CiliaryGanglion23
CingulateCortex30.7
Colorectaladenocarcinoma41.1
DorsalRootGanglion23.3
FetalThyroid33.25
Fetalbrain71.75
Fetalliver27.35
Fetallung40.25
GlobusPallidus21.5
Heart54.5
Hypothalamus25.25
Kidney24.15
Leukemia_chronicMyelogenousK-56263.65
Leukemia_promyelocytic-HL-6032.6
Leukemialymphoblastic(MOLT-4)83.15
Liver41.25
Lung40.6
Lymphnode25.75
Lymphoma_burkitts(Daudi)56.65
Lymphoma_burkitts(Raji)57.15
MedullaOblongata27.45
OccipitalLobe26.15
OlfactoryBulb23.7
Ovary28.7
Pancreas32.05
PancreaticIslet31.55
ParietalLobe37.35
Pituitary35.4
Placenta69.15
Pons27.75
PrefrontalCortex34.55
Prostate36.7
Salivarygland24.05
SkeletalMuscle41.5
Skin22.35
SmoothMuscle56.85
Spinalcord29.25
SubthalamicNucleus26.75
SuperiorCervicalGanglion35.8
TemporalLobe27.1
Testis47.65
TestisGermCell48.9
TestisIntersitial26.8
TestisLeydigCell41.55
TestisSeminiferousTubule34.5
Thalamus29.25
Thymus25.7
Thyroid38.85
Tongue43.5
Tonsil31.75
Trachea25.5
TrigeminalGanglion42.35
Uterus37.25
UterusCorpus39.25
WholeBlood35.85
Wholebrain26.8
colon25.1
pineal_day37.18
pineal_night35.42
retina37.95
small_intestine24.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P10135
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.45 ± 0.48
Basal Forebrain4.8 ± 0.22
Basal Part of Pons5.06 ± 0.31
Cerebellar Cortex5.2 ± 0.39
Cerebellar Nuclei5.01 ± 0.4
Claustrum4.46 ± 0.8
Epithalamus4.76 ± 0.6
Frontal Lobe4.97 ± 0.49
Globus Pallidus4.35 ± 0.3
Hypothalamus4.62 ± 0.54
Insula4.93 ± 0.44
Limbic Lobe4.73 ± 0.51
Mesencephalon4.79 ± 0.53
Myelencephalon4.84 ± 0.51
Occipital Lobe4.63 ± 0.39
Parietal Lobe4.73 ± 0.45
Pontine Tegmentum4.79 ± 0.5
Striatum4.56 ± 0.44
Subthalamus4.37 ± 0.26
Temporal Lobe4.98 ± 0.45
Thalamus4.92 ± 0.44
White Matter5.25 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nkiras2CBCerebellum59.52
37.15
Nkiras2CTXCerebral cortex38.95
25.07
Nkiras2HIPHippocampal region32.17
21.79
Nkiras2HPFHippocampal formation37.55
27.06
Nkiras2HYHypothalamus20.54
14.15
Nkiras2LSXLateral septal complex21.17
10.98
Nkiras2MBMidbrain16.88
10.75
Nkiras2MYMedulla34.73
23.63
Nkiras2OLFOlfactory bulb59.33
33.75
Nkiras2PPons25.63
18.39
Nkiras2PALPallidum12.81
8.11
Nkiras2RHPRetrohippocampal region43.25
31.67
Nkiras2sAMYStriatum-like amygdalar nuclei20.59
13.9
Nkiras2STRStriatum20.28
11.21
Nkiras2STRdStriatum dorsal region14.99
8.23
Nkiras2STRvStriatum ventral region36.81
18.52
Nkiras2THThalamus17
11.52
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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