AutismKB 2.0

Annotation Detail for GRK5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GRK5 ( FLJ39780,GPRK5 )
Gene Full Name: G protein-coupled receptor kinase 5
Band: 10q26.11
Quick LinksEntrez ID:2869; OMIM: 600870; Uniprot ID:GRK5_HUMAN; ENSEMBL ID: ENSG00000198873; HGNC ID: 4544
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus31 / 56401254
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma4 / 10688337
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma14 / 71755195
non-neoplasia2 / 9725020
normal116 / 336030734
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow1 / 4880120
brain44 / 110098939
cervix3 / 4817162
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye7 / 21105433
heart5 / 8962655
intestine13 / 23447255
kidney8 / 21177737
larynx0 / 241450 
liver0 / 2077430 
lung19 / 33697456
lymph14 / 44270316
lymph node5 / 9161054
mammary gland4 / 15327126
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas2 / 2148129
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate3 / 18934515
salivary gland0 / 201550 
skin10 / 21057447
spleen5 / 5395292
stomach1 / 9661910
testis4 / 33044212
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus14 / 23287860
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204395_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.3
Adipocyte5.4
AdrenalCortex5.05
Adrenalgland4.15
Amygdala5.15
Appendix5.8
AtrioventricularNode3.75
BDCA4+_DentriticCells5.5
Bonemarrow5.3
BronchialEpithelialCells5.15
CD105+_Endothelial4.95
CD14+_Monocytes5.25
CD19+_BCells(neg._sel.)5.3
CD33+_Myeloid6.3
CD34+5.8
CD4+_Tcells5.65
CD56+_NKCells6.55
CD71+_EarlyErythroid4.55
CD8+_Tcells4.8
CardiacMyocytes9.5
Caudatenucleus4.45
Cerebellum4.15
CerebellumPeduncles8.05
CiliaryGanglion3.7
CingulateCortex5
Colorectaladenocarcinoma4.8
DorsalRootGanglion3.75
FetalThyroid4.8
Fetalbrain5.5
Fetalliver4.25
Fetallung5.15
GlobusPallidus3.6
Heart7.8
Hypothalamus5.3
Kidney3.9
Leukemia_chronicMyelogenousK-5624.45
Leukemia_promyelocytic-HL-604.25
Leukemialymphoblastic(MOLT-4)4
Liver6.5
Lung21.35
Lymphnode4.25
Lymphoma_burkitts(Daudi)6.15
Lymphoma_burkitts(Raji)6.8
MedullaOblongata5.3
OccipitalLobe4.45
OlfactoryBulb3.9
Ovary5.65
Pancreas4
PancreaticIslet5.45
ParietalLobe5.2
Pituitary5.7
Placenta5.85
Pons7.9
PrefrontalCortex6.15
Prostate5.8
Salivarygland3.9
SkeletalMuscle5.65
Skin3.75
SmoothMuscle10.3
Spinalcord5.2
SubthalamicNucleus4.45
SuperiorCervicalGanglion5.55
TemporalLobe4.55
Testis4.3
TestisGermCell4.2
TestisIntersitial5.1
TestisLeydigCell4.9
TestisSeminiferousTubule4.25
Thalamus4.95
Thymus4.3
Thyroid6.25
Tongue4.75
Tonsil4.8
Trachea4.15
TrigeminalGanglion4.9
Uterus4.1
UterusCorpus5.35
WholeBlood6.3
Wholebrain4.2
colon5
pineal_day6.08
pineal_night6.02
retina6.05
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12416_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.72 ± 0.6
Basal Forebrain4.24 ± 0.51
Basal Part of Pons3.3 ± 0.68
Cerebellar Cortex3.95 ± 0.34
Cerebellar Nuclei4 ± 0.27
Claustrum3.4 ± 0.77
Epithalamus3.12 ± 0.61
Frontal Lobe3.52 ± 0.6
Globus Pallidus2.91 ± 0.49
Hypothalamus3.33 ± 0.56
Insula3.74 ± 0.55
Limbic Lobe3.42 ± 0.64
Mesencephalon3.61 ± 0.61
Myelencephalon3.66 ± 0.54
Occipital Lobe3.6 ± 0.5
Parietal Lobe3.71 ± 0.51
Pontine Tegmentum3.59 ± 0.52
Striatum3.79 ± 0.51
Subthalamus3.45 ± 0.17
Temporal Lobe3.8 ± 0.45
Thalamus3.66 ± 0.57
White Matter2.17 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gprk5CBCerebellum2.97
2.58
Gprk5CTXCerebral cortex12.99
7.24
Gprk5HIPHippocampal region4.87
3.79
Gprk5HPFHippocampal formation5.1
3.97
Gprk5HYHypothalamus4.19
2.69
Gprk5LSXLateral septal complex36.43
22.03
Gprk5MBMidbrain1.64
1.9
Gprk5MYMedulla2.86
2.92
Gprk5OLFOlfactory bulb19.93
10.32
Gprk5PPons2.04
2.73
Gprk5PALPallidum10.47
6.45
Gprk5RHPRetrohippocampal region5.13
3.92
Gprk5sAMYStriatum-like amygdalar nuclei15.16
9.47
Gprk5STRStriatum16.15
9.1
Gprk5STRdStriatum dorsal region12.9
7.52
Gprk5STRvStriatum ventral region19.91
9.08
Gprk5THThalamus6.77
4.33
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved