AutismKB 2.0

Annotation Detail for ANK2


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Basic Information Top
Gene Symbol:ANK2 ( DKFZp686M09125,DKFZp686P0948,FLJ38277,LQT4 )
Gene Full Name: ankyrin 2, neuronal
Band: 4q25-q26
Quick LinksEntrez ID:287; OMIM: 106410; Uniprot ID:ANK2_HUMAN; ENSEMBL ID: ENSG00000145362; HGNC ID: 493
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst6 / 6231996
fetus99 / 564012175
neonate0 / 310970 
infant1 / 2362042
juvenile4 / 5555671
adult105 / 193912154
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma6 / 10688356
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia8 / 9725082
normal359 / 3360307106
ovarian tumor7 / 7668291
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain227 / 1100989206
cervix0 / 481710 
connective tissue10 / 14925566
ear1 / 1621261
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye28 / 211054132
heart10 / 89626111
intestine7 / 23447229
kidney25 / 211777118
larynx0 / 241450 
liver2 / 2077439
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle16 / 107715148
nerve5 / 15768317
ovary5 / 10205148
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate4 / 18934521
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach0 / 966190 
testis9 / 33044227
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202920_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.95
Adipocyte86.7
AdrenalCortex9
Adrenalgland6.7
Amygdala1030.1
Appendix63.1
AtrioventricularNode11.4
BDCA4+_DentriticCells7.35
Bonemarrow8
BronchialEpithelialCells7.1
CD105+_Endothelial7.45
CD14+_Monocytes7.9
CD19+_BCells(neg._sel.)7.85
CD33+_Myeloid9.35
CD34+8.9
CD4+_Tcells7.65
CD56+_NKCells8.4
CD71+_EarlyErythroid7.35
CD8+_Tcells6.75
CardiacMyocytes11.5
Caudatenucleus549.75
Cerebellum209
CerebellumPeduncles527
CiliaryGanglion102.4
CingulateCortex680.1
Colorectaladenocarcinoma7.65
DorsalRootGanglion149.3
FetalThyroid32.85
Fetalbrain2065.85
Fetalliver6.7
Fetallung6.35
GlobusPallidus438.55
Heart11
Hypothalamus1261.9
Kidney128.3
Leukemia_chronicMyelogenousK-5626.75
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)5.8
Liver11.15
Lung8
Lymphnode13.4
Lymphoma_burkitts(Daudi)10.45
Lymphoma_burkitts(Raji)12
MedullaOblongata754.05
OccipitalLobe1071.4
OlfactoryBulb82.8
Ovary6.1
Pancreas6.25
PancreaticIslet8.15
ParietalLobe1019.3
Pituitary73.65
Placenta7.35
Pons546.55
PrefrontalCortex1899.3
Prostate8.7
Salivarygland6.45
SkeletalMuscle12.1
Skin8.9
SmoothMuscle8.5
Spinalcord483.6
SubthalamicNucleus769.15
SuperiorCervicalGanglion16.7
TemporalLobe501.8
Testis6.5
TestisGermCell18.05
TestisIntersitial7.3
TestisLeydigCell8.15
TestisSeminiferousTubule6.65
Thalamus939.65
Thymus5.7
Thyroid13.45
Tongue31.5
Tonsil7.8
Trachea6.4
TrigeminalGanglion48.15
Uterus32.25
UterusCorpus10.85
WholeBlood8.15
Wholebrain378.15
colon17.3
pineal_day513.34
pineal_night315.64
retina326.125
small_intestine7.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P133068
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9 ± 0.24
Basal Forebrain8.75 ± 0.18
Basal Part of Pons8.97 ± 0.21
Cerebellar Cortex8.53 ± 0.29
Cerebellar Nuclei8.81 ± 0.35
Claustrum9.17 ± 0.53
Epithalamus8.21 ± 0.34
Frontal Lobe8.71 ± 0.32
Globus Pallidus8.35 ± 0.25
Hypothalamus8.54 ± 0.31
Insula8.73 ± 0.17
Limbic Lobe8.92 ± 0.37
Mesencephalon8.76 ± 0.4
Myelencephalon8.76 ± 0.31
Occipital Lobe8.98 ± 0.37
Parietal Lobe8.78 ± 0.33
Pontine Tegmentum8.71 ± 0.34
Striatum8.85 ± 0.37
Subthalamus8.66 ± 0.33
Temporal Lobe8.69 ± 0.25
Thalamus8.87 ± 0.34
White Matter8.01 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ank2CBCerebellum100
100
Ank2CTXCerebral cortex100
100
Ank2HIPHippocampal region100
100
Ank2HPFHippocampal formation100
100
Ank2HYHypothalamus100
100
Ank2LSXLateral septal complex100
100
Ank2MBMidbrain100
100
Ank2MYMedulla100
100
Ank2OLFOlfactory bulb100
100
Ank2PPons100
100
Ank2PALPallidum100
100
Ank2RHPRetrohippocampal region100
100
Ank2sAMYStriatum-like amygdalar nuclei100
100
Ank2STRStriatum100
100
Ank2STRdStriatum dorsal region100
100
Ank2STRvStriatum ventral region100
100
Ank2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024174 13 395 407 ALNGFTPLHIACK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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