AutismKB 2.0

Annotation Detail for MKNK2


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Basic Information Top
Gene Symbol:MKNK2 ( GPRK7,MNK2 )
Gene Full Name: MAP kinase interacting serine/threonine kinase 2
Band: 19p13.3
Quick LinksEntrez ID:2872; OMIM: 605069; Uniprot ID:MKNK2_HUMAN; ENSEMBL ID: ENSG00000099875; HGNC ID: 7111
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst9 / 62319144
fetus18 / 56401231
neonate0 / 310970 
infant1 / 2362042
juvenile4 / 5555671
adult159 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor14 / 114246122
esophageal tumor1 / 1729057
gastrointestinal tumor21 / 119369175
germ cell tumor23 / 26384587
glioma11 / 106883102
head and neck tumor12 / 13630288
kidney tumor6 / 6895987
leukemia12 / 95842125
liver tumor10 / 96359103
lung tumor19 / 103127184
lymphoma13 / 71755181
non-neoplasia5 / 9725051
normal212 / 336030763
ovarian tumor7 / 7668291
pancreatic tumor25 / 104616238
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer14 / 102680136
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites16 / 40015399
bladder2 / 2975767
blood10 / 12347880
bone4 / 7165555
bone marrow2 / 4880140
brain45 / 110098940
cervix3 / 4817162
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus1 / 2020949
eye26 / 211054123
heart9 / 89626100
intestine23 / 23447298
kidney13 / 21177761
larynx2 / 2414582
liver11 / 20774352
lung42 / 336974124
lymph12 / 44270271
lymph node13 / 91610141
mammary gland8 / 15327152
mouth11 / 67052164
muscle12 / 107715111
nerve1 / 1576863
ovary12 / 102051117
pancreas27 / 214812125
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta16 / 28082556
prostate19 / 189345100
salivary gland0 / 201550 
skin11 / 21057452
spleen3 / 5395255
stomach11 / 96619113
testis24 / 33044272
thymus13 / 81131160
thyroid1 / 4747321
tonsil2 / 16999117
trachea3 / 5241357
umbilical cord0 / 136800 
uterus20 / 23287885
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218205_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5740.75
Adipocyte1377.3
AdrenalCortex671.25
Adrenalgland327.75
Amygdala111.85
Appendix109.35
AtrioventricularNode179.9
BDCA4+_DentriticCells1176.55
Bonemarrow412.75
BronchialEpithelialCells1833.05
CD105+_Endothelial2670.55
CD14+_Monocytes1223.5
CD19+_BCells(neg._sel.)2372.9
CD33+_Myeloid1378.1
CD34+682.35
CD4+_Tcells1208.15
CD56+_NKCells1347.35
CD71+_EarlyErythroid2785.8
CD8+_Tcells1174.5
CardiacMyocytes292.85
Caudatenucleus73.05
Cerebellum386.5
CerebellumPeduncles438.55
CiliaryGanglion97.85
CingulateCortex84.2
Colorectaladenocarcinoma566.85
DorsalRootGanglion62.95
FetalThyroid559.3
Fetalbrain108.8
Fetalliver332.5
Fetallung593.45
GlobusPallidus28.85
Heart1272.45
Hypothalamus128.85
Kidney158.15
Leukemia_chronicMyelogenousK-5621022.1
Leukemia_promyelocytic-HL-601365.2
Leukemialymphoblastic(MOLT-4)181.45
Liver604.9
Lung1690.75
Lymphnode515.65
Lymphoma_burkitts(Daudi)434.3
Lymphoma_burkitts(Raji)3013.3
MedullaOblongata57.55
OccipitalLobe53.3
OlfactoryBulb465.3
Ovary72.2
Pancreas719.85
PancreaticIslet868.85
ParietalLobe56.6
Pituitary165.25
Placenta970.9
Pons29.75
PrefrontalCortex288
Prostate1753
Salivarygland453.9
SkeletalMuscle2488
Skin219.05
SmoothMuscle287.7
Spinalcord102
SubthalamicNucleus37.75
SuperiorCervicalGanglion53.25
TemporalLobe41.85
Testis474.75
TestisGermCell229.95
TestisIntersitial124.25
TestisLeydigCell194.75
TestisSeminiferousTubule218.65
Thalamus62.4
Thymus596.15
Thyroid1521.25
Tongue2328.1
Tonsil891.5
Trachea402.75
TrigeminalGanglion127.25
Uterus387.35
UterusCorpus33.25
WholeBlood1482.6
Wholebrain145.9
colon800.1
pineal_day871.7
pineal_night742.28
retina844.45
small_intestine410.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P142304
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.78 ± 0.57
Basal Forebrain5.7 ± 0.25
Basal Part of Pons5.71 ± 0.26
Cerebellar Cortex6.14 ± 0.17
Cerebellar Nuclei5.66 ± 0.38
Claustrum6.03 ± 0.67
Epithalamus5.63 ± 0.42
Frontal Lobe5.46 ± 0.36
Globus Pallidus5.84 ± 0.39
Hypothalamus5.32 ± 0.41
Insula5.5 ± 0.37
Limbic Lobe5.79 ± 0.56
Mesencephalon5.56 ± 0.53
Myelencephalon5.67 ± 0.5
Occipital Lobe6.2 ± 0.54
Parietal Lobe5.76 ± 0.38
Pontine Tegmentum5.7 ± 0.51
Striatum5.55 ± 0.54
Subthalamus5.63 ± 0.25
Temporal Lobe5.55 ± 0.46
Thalamus5.79 ± 0.35
White Matter5.78 ± 0.31
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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