AutismKB 2.0

Annotation Detail for GPS1


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Basic Information Top
Gene Symbol:GPS1 ( COPS1,CSN1,MGC71287 )
Gene Full Name: G protein pathway suppressor 1
Band: 17q25.3
Quick LinksEntrez ID:2873; OMIM: 601934; Uniprot ID:CSN1_HUMAN; ENSEMBL ID: ENSG00000169727; HGNC ID: 4549
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst10 / 62319160
fetus64 / 564012113
neonate3 / 3109796
infant15 / 23620635
juvenile32 / 55556575
adult244 / 1939121125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor18 / 94178191
cervical tumor3 / 3436687
chondrosarcoma12 / 82823144
colorectal tumor18 / 114246157
esophageal tumor5 / 17290289
gastrointestinal tumor15 / 119369125
germ cell tumor33 / 263845125
glioma35 / 106883327
head and neck tumor15 / 136302110
kidney tumor15 / 68959217
leukemia17 / 95842177
liver tumor18 / 96359186
lung tumor33 / 103127319
lymphoma20 / 71755278
non-neoplasia15 / 97250154
normal523 / 3360307155
ovarian tumor13 / 76682169
pancreatic tumor19 / 104616181
primitive neuroectodermal tumor of the CNS67 / 125680533
prostate cancer19 / 102680185
retinoblastoma16 / 46356345
skin tumor32 / 124949256
soft tissue/muscle tissue tumor20 / 125191159
uterine tumor19 / 90257210
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland10 / 33197301
ascites5 / 40015124
bladder9 / 29757302
blood26 / 123478210
bone10 / 71655139
bone marrow2 / 4880140
brain244 / 1100989221
cervix10 / 48171207
connective tissue19 / 149255127
ear0 / 162120 
embryonic tissue16 / 21572274
esophagus5 / 20209247
eye36 / 211054170
heart24 / 89626267
intestine56 / 234472238
kidney39 / 211777184
larynx1 / 2414541
liver25 / 207743120
lung53 / 336974157
lymph11 / 44270248
lymph node15 / 91610163
mammary gland28 / 153271182
mouth5 / 6705274
muscle15 / 107715139
nerve2 / 15768126
ovary23 / 102051225
pancreas23 / 214812107
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland5 / 16585301
placenta42 / 280825149
prostate28 / 189345147
salivary gland5 / 20155248
skin38 / 210574180
spleen11 / 53952203
stomach15 / 96619155
testis51 / 330442154
thymus13 / 81131160
thyroid7 / 47473147
tonsil3 / 16999176
trachea2 / 5241338
umbilical cord1 / 1368073
uterus39 / 232878167
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217782_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts104.75
Adipocyte22.35
AdrenalCortex22.45
Adrenalgland18.6
Amygdala33.9
Appendix22.05
AtrioventricularNode16.4
BDCA4+_DentriticCells40.6
Bonemarrow21.65
BronchialEpithelialCells26
CD105+_Endothelial23.05
CD14+_Monocytes47
CD19+_BCells(neg._sel.)23.55
CD33+_Myeloid38.85
CD34+57.25
CD4+_Tcells34.5
CD56+_NKCells44.95
CD71+_EarlyErythroid22
CD8+_Tcells33.9
CardiacMyocytes28.8
Caudatenucleus24.1
Cerebellum20.15
CerebellumPeduncles41.75
CiliaryGanglion14.1
CingulateCortex25.2
Colorectaladenocarcinoma40.75
DorsalRootGanglion15.85
FetalThyroid22.25
Fetalbrain24.65
Fetalliver19.05
Fetallung18.9
GlobusPallidus17.95
Heart67.9
Hypothalamus25
Kidney20.5
Leukemia_chronicMyelogenousK-56220.6
Leukemia_promyelocytic-HL-6019.65
Leukemialymphoblastic(MOLT-4)23.5
Liver77.25
Lung37.05
Lymphnode17.7
Lymphoma_burkitts(Daudi)28.25
Lymphoma_burkitts(Raji)31.3
MedullaOblongata24.4
OccipitalLobe26.7
OlfactoryBulb17.65
Ovary14.6
Pancreas16.45
PancreaticIslet21.1
ParietalLobe23.9
Pituitary26.35
Placenta22.5
Pons21.85
PrefrontalCortex30.45
Prostate48.55
Salivarygland16.2
SkeletalMuscle25.95
Skin14.2
SmoothMuscle25.7
Spinalcord28.2
SubthalamicNucleus19.95
SuperiorCervicalGanglion24.55
TemporalLobe26.8
Testis20.85
TestisGermCell30.25
TestisIntersitial18.75
TestisLeydigCell23.45
TestisSeminiferousTubule24.6
Thalamus26.3
Thymus21
Thyroid62.25
Tongue19.75
Tonsil21.3
Trachea18.75
TrigeminalGanglion21.45
Uterus17.35
UterusCorpus20.5
WholeBlood24.65
Wholebrain44.75
colon22.75
pineal_day68.58
pineal_night61.26
retina41.5
small_intestine22
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_750_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.63 ± 0.63
Basal Forebrain5.68 ± 0.28
Basal Part of Pons6.13 ± 0.79
Cerebellar Cortex6.23 ± 0.59
Cerebellar Nuclei5.24 ± 0.7
Claustrum4.91 ± 0.99
Epithalamus6.31 ± 0.71
Frontal Lobe6.07 ± 0.62
Globus Pallidus5.26 ± 0.24
Hypothalamus6.08 ± 0.74
Insula5.98 ± 0.37
Limbic Lobe5.55 ± 0.78
Mesencephalon5.74 ± 0.61
Myelencephalon5.68 ± 0.78
Occipital Lobe5.12 ± 0.74
Parietal Lobe5.66 ± 0.66
Pontine Tegmentum5.7 ± 0.61
Striatum5.08 ± 0.57
Subthalamus5.62 ± 0.38
Temporal Lobe5.96 ± 0.6
Thalamus5.68 ± 0.64
White Matter5.65 ± 0.58
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gps1CBCerebellum7.01
12.78
Gps1CTXCerebral cortex66.57
72.08
Gps1HIPHippocampal region99.46
100
Gps1HPFHippocampal formation79.03
100
Gps1HYHypothalamus88.91
100
Gps1LSXLateral septal complex30.08
35.71
Gps1MBMidbrain23.18
35.82
Gps1MYMedulla7.25
15.31
Gps1OLFOlfactory bulb32.32
41.66
Gps1PPons19.25
37.37
Gps1PALPallidum58.16
78.02
Gps1RHPRetrohippocampal region40.44
47.98
Gps1sAMYStriatum-like amygdalar nuclei92.44
93.36
Gps1STRStriatum42.2
40.16
Gps1STRdStriatum dorsal region36.54
32.35
Gps1STRvStriatum ventral region39.84
38.98
Gps1THThalamus62.78
75.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CSN1_HUMAN_330 14 330 343 DNLLLDMYLAPHVR PRIDE
CSN1_HUMAN_69 12 69 80 TFNVDMYEEIHR PRIDE
PAp00002843 20 164 183 GHDDLGDHYLDCGDLSNALK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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