AutismKB 2.0

Annotation Detail for GRB10


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Basic Information Top
Gene Symbol:GRB10 ( GRB-IR,Grb-10,IRBP,KIAA0207,MEG1,RSS )
Gene Full Name: growth factor receptor-bound protein 10
Band: 7p12.1
Quick LinksEntrez ID:2887; OMIM: 601523; Uniprot ID:GRB10_HUMAN; ENSEMBL ID: ENSG00000106070; HGNC ID: 4564
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus31 / 56401254
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor23 / 26384587
glioma6 / 10688356
head and neck tumor5 / 13630236
kidney tumor8 / 68959116
leukemia7 / 9584273
liver tumor1 / 9635910
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal156 / 336030746
ovarian tumor0 / 766820 
pancreatic tumor14 / 104616133
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer9 / 10268087
retinoblastoma2 / 4635643
skin tumor5 / 12494940
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood6 / 12347848
bone1 / 7165513
bone marrow2 / 4880140
brain62 / 110098956
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye20 / 21105494
heart4 / 8962644
intestine4 / 23447217
kidney11 / 21177751
larynx1 / 2414541
liver11 / 20774352
lung16 / 33697447
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle3 / 10771527
nerve1 / 1576863
ovary2 / 10205119
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta3 / 28082510
prostate12 / 18934563
salivary gland1 / 2015549
skin7 / 21057433
spleen3 / 5395255
stomach6 / 9661962
testis29 / 33044287
thymus2 / 8113124
thyroid4 / 4747384
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus7 / 23287830
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209410_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.5
Adipocyte24.8
AdrenalCortex22.05
Adrenalgland16.35
Amygdala20.75
Appendix19.35
AtrioventricularNode14.45
BDCA4+_DentriticCells14.8
Bonemarrow19.65
BronchialEpithelialCells30.75
CD105+_Endothelial23.65
CD14+_Monocytes20.15
CD19+_BCells(neg._sel.)19.05
CD33+_Myeloid24.15
CD34+24.3
CD4+_Tcells19.35
CD56+_NKCells19.25
CD71+_EarlyErythroid17.55
CD8+_Tcells12.6
CardiacMyocytes40.1
Caudatenucleus17.55
Cerebellum19.25
CerebellumPeduncles30.05
CiliaryGanglion13.45
CingulateCortex20.25
Colorectaladenocarcinoma19.5
DorsalRootGanglion14.75
FetalThyroid18.8
Fetalbrain19.6
Fetalliver16.6
Fetallung17.8
GlobusPallidus14
Heart24.65
Hypothalamus23.05
Kidney16.45
Leukemia_chronicMyelogenousK-56232.65
Leukemia_promyelocytic-HL-6016.1
Leukemialymphoblastic(MOLT-4)15.9
Liver27.7
Lung24.6
Lymphnode16.9
Lymphoma_burkitts(Daudi)24.55
Lymphoma_burkitts(Raji)26.7
MedullaOblongata19.05
OccipitalLobe17.6
OlfactoryBulb15.45
Ovary13.15
Pancreas30.2
PancreaticIslet32.05
ParietalLobe20.45
Pituitary30.1
Placenta18.9
Pons19.25
PrefrontalCortex24.45
Prostate22.25
Salivarygland15.55
SkeletalMuscle27.35
Skin14.75
SmoothMuscle40
Spinalcord20.5
SubthalamicNucleus17.5
SuperiorCervicalGanglion21.65
TemporalLobe18.35
Testis36.8
TestisGermCell16.5
TestisIntersitial28.5
TestisLeydigCell24.75
TestisSeminiferousTubule19.15
Thalamus19.8
Thymus15.15
Thyroid24.8
Tongue31.55
Tonsil18.85
Trachea16.15
TrigeminalGanglion21.65
Uterus15.45
UterusCorpus17.45
WholeBlood20.45
Wholebrain16
colon19.4
pineal_day27.42
pineal_night26.16
retina23.125
small_intestine18.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P122863
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.32 ± 0.28
Basal Forebrain7.54 ± 0.21
Basal Part of Pons7.4 ± 0.25
Cerebellar Cortex6.98 ± 0.13
Cerebellar Nuclei7.73 ± 0.16
Claustrum7.41 ± 0.23
Epithalamus6.86 ± 0.49
Frontal Lobe7.19 ± 0.28
Globus Pallidus7.85 ± 0.11
Hypothalamus7.43 ± 0.31
Insula7.18 ± 0.36
Limbic Lobe7.09 ± 0.32
Mesencephalon7.44 ± 0.36
Myelencephalon7.29 ± 0.35
Occipital Lobe7.1 ± 0.24
Parietal Lobe7.24 ± 0.32
Pontine Tegmentum7.19 ± 0.25
Striatum8.04 ± 0.31
Subthalamus7.43 ± 0.12
Temporal Lobe7.22 ± 0.23
Thalamus7.38 ± 0.19
White Matter8.21 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grb10CBCerebellum0.84
1.38
Grb10CTXCerebral cortex0.37
0.37
Grb10HIPHippocampal region0.64
0.57
Grb10HPFHippocampal formation0.7
0.56
Grb10HYHypothalamus13.2
10.02
Grb10LSXLateral septal complex1.62
1.29
Grb10MBMidbrain6.4
6.12
Grb10MYMedulla4.43
4.41
Grb10OLFOlfactory bulb1.27
1.14
Grb10PPons4.91
4.74
Grb10PALPallidum3.38
2.49
Grb10RHPRetrohippocampal region0.64
0.44
Grb10sAMYStriatum-like amygdalar nuclei2.76
1.88
Grb10STRStriatum0.73
0.54
Grb10STRdStriatum dorsal region0.31
0.29
Grb10STRvStriatum ventral region0.8
0.43
Grb10THThalamus3.38
2.62
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00041296 17 294 310 KQYNAPTDHGLCIKPNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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