AutismKB 2.0

Annotation Detail for GRIA1


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Basic Information Top
Gene Symbol:GRIA1 ( GLUH1,GLUR1,GLURA,GluA1,HBGR1,MGC133252 )
Gene Full Name: glutamate receptor, ionotropic, AMPA 1
Band: 5q33.2
Quick LinksEntrez ID:2890; OMIM: 138248; Uniprot ID:GRIA1_HUMAN; ENSEMBL ID: ENSG00000155511; HGNC ID: 4571
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus21 / 56401237
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor11 / 26384541
glioma8 / 10688374
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal179 / 336030753
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain151 / 1100989137
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211520_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.5
Adipocyte10.7
AdrenalCortex17.6
Adrenalgland10.95
Amygdala40.45
Appendix21.6
AtrioventricularNode18.45
BDCA4+_DentriticCells10.45
Bonemarrow13.35
BronchialEpithelialCells10.65
CD105+_Endothelial11.1
CD14+_Monocytes12.4
CD19+_BCells(neg._sel.)11.75
CD33+_Myeloid13.45
CD34+13.25
CD4+_Tcells11.45
CD56+_NKCells12
CD71+_EarlyErythroid11.35
CD8+_Tcells9.1
CardiacMyocytes26.75
Caudatenucleus10.6
Cerebellum27.25
CerebellumPeduncles20.1
CiliaryGanglion18.15
CingulateCortex21.15
Colorectaladenocarcinoma11.3
DorsalRootGanglion14.85
FetalThyroid11.9
Fetalbrain30.2
Fetalliver10.2
Fetallung9
GlobusPallidus11.3
Heart23.4
Hypothalamus12.3
Kidney10.7
Leukemia_chronicMyelogenousK-56210.5
Leukemia_promyelocytic-HL-6010.2
Leukemialymphoblastic(MOLT-4)8.5
Liver20.35
Lung12.75
Lymphnode9.4
Lymphoma_burkitts(Daudi)15.6
Lymphoma_burkitts(Raji)19.2
MedullaOblongata10.75
OccipitalLobe15.95
OlfactoryBulb8.7
Ovary9.65
Pancreas10.45
PancreaticIslet12.65
ParietalLobe14.1
Pituitary13.6
Placenta10.85
Pons29.7
PrefrontalCortex13.9
Prostate12.45
Salivarygland10.7
SkeletalMuscle22.25
Skin18.8
SmoothMuscle13.2
Spinalcord12.05
SubthalamicNucleus13.1
SuperiorCervicalGanglion29.95
TemporalLobe11.45
Testis9.85
TestisGermCell8.8
TestisIntersitial10.45
TestisLeydigCell12.55
TestisSeminiferousTubule10.1
Thalamus12.35
Thymus8.05
Thyroid12.8
Tongue14.75
Tonsil11.95
Trachea9.35
TrigeminalGanglion20.4
Uterus8.75
UterusCorpus16.3
WholeBlood12.1
Wholebrain12.65
colon10.9
pineal_day16.24
pineal_night13.44
retina14.25
small_intestine10.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13838_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.75 ± 0.79
Basal Forebrain8.9 ± 0.4
Basal Part of Pons7.06 ± 0.41
Cerebellar Cortex7.99 ± 0.43
Cerebellar Nuclei6.66 ± 0.66
Claustrum9.39 ± 0.92
Epithalamus7.77 ± 0.4
Frontal Lobe8.39 ± 0.82
Globus Pallidus5.96 ± 1.5
Hypothalamus8.04 ± 0.88
Insula8.82 ± 0.71
Limbic Lobe9.69 ± 0.76
Mesencephalon8.43 ± 0.9
Myelencephalon8.3 ± 1.23
Occipital Lobe7.89 ± 0.66
Parietal Lobe8.25 ± 0.96
Pontine Tegmentum8.5 ± 0.84
Striatum9.07 ± 0.84
Subthalamus8.62 ± 0.2
Temporal Lobe8.84 ± 0.78
Thalamus7.18 ± 0.87
White Matter4.49 ± 0.96
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gria1CBCerebellum8.31
9.07
Gria1CTXCerebral cortex13.15
8.01
Gria1HIPHippocampal region81.76
100
Gria1HPFHippocampal formation64.12
74.45
Gria1HYHypothalamus4.04
2.5
Gria1LSXLateral septal complex44.28
31.24
Gria1MBMidbrain3.27
2.09
Gria1MYMedulla0.67
0.63
Gria1OLFOlfactory bulb26.88
15.87
Gria1PPons3.02
1.57
Gria1PALPallidum6.65
4.2
Gria1RHPRetrohippocampal region40.26
30.58
Gria1sAMYStriatum-like amygdalar nuclei16.51
8.71
Gria1STRStriatum18.88
10.26
Gria1STRdStriatum dorsal region12.79
6.89
Gria1STRvStriatum ventral region32.74
14.93
Gria1THThalamus4.31
2.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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