AutismKB 2.0

Annotation Detail for TMEM176B


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Basic Information Top
Gene Symbol:TMEM176B ( FLJ26014,LR8,MGC110857 )
Gene Full Name: transmembrane protein 176B
Band: 7q36.1
Quick LinksEntrez ID:28959; OMIM: 610385; Uniprot ID:T176B_HUMAN; ENSEMBL ID: ENSG00000106565; HGNC ID: 29596
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult146 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor2 / 2638457
glioma7 / 10688365
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor7 / 10312767
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal153 / 336030745
ovarian tumor12 / 76682156
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood9 / 12347872
bone2 / 7165527
bone marrow0 / 488010 
brain19 / 110098917
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye15 / 21105471
heart3 / 8962633
intestine31 / 234472132
kidney14 / 21177766
larynx0 / 241450 
liver22 / 207743105
lung17 / 33697450
lymph0 / 442700 
lymph node2 / 9161021
mammary gland11 / 15327171
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary15 / 102051146
pancreas18 / 21481283
parathyroid0 / 205390 
pharynx7 / 41328169
pituitary gland2 / 16585120
placenta21 / 28082574
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach3 / 9661931
testis2 / 3304426
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220532_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte6.85
AdrenalCortex7.6
Adrenalgland9.05
Amygdala9.2
Appendix24.35
AtrioventricularNode5.8
BDCA4+_DentriticCells106.25
Bonemarrow6.05
BronchialEpithelialCells5.15
CD105+_Endothelial16.45
CD14+_Monocytes1323.1
CD19+_BCells(neg._sel.)6.15
CD33+_Myeloid781.55
CD34+6.95
CD4+_Tcells5.95
CD56+_NKCells7.55
CD71+_EarlyErythroid5.5
CD8+_Tcells5.3
CardiacMyocytes8.1
Caudatenucleus5.6
Cerebellum4.8
CerebellumPeduncles6.75
CiliaryGanglion6.8
CingulateCortex6.15
Colorectaladenocarcinoma5.85
DorsalRootGanglion72.7
FetalThyroid6.05
Fetalbrain5.55
Fetalliver365
Fetallung78.3
GlobusPallidus4.4
Heart146.1
Hypothalamus8.95
Kidney912
Leukemia_chronicMyelogenousK-5625.15
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)4.45
Liver6648.35
Lung131.4
Lymphnode151.9
Lymphoma_burkitts(Daudi)7.4
Lymphoma_burkitts(Raji)8.7
MedullaOblongata5.15
OccipitalLobe5.1
OlfactoryBulb117.15
Ovary112.25
Pancreas90.85
PancreaticIslet359.45
ParietalLobe6.3
Pituitary8.5
Placenta248.25
Pons6.35
PrefrontalCortex12.4
Prostate12.2
Salivarygland5.65
SkeletalMuscle7.4
Skin4.95
SmoothMuscle6.35
Spinalcord44.15
SubthalamicNucleus6.4
SuperiorCervicalGanglion7.55
TemporalLobe8.15
Testis6.1
TestisGermCell15
TestisIntersitial4.85
TestisLeydigCell5.85
TestisSeminiferousTubule5.3
Thalamus6.2
Thymus32.25
Thyroid8
Tongue6.55
Tonsil63.8
Trachea4.8
TrigeminalGanglion16.4
Uterus10.4
UterusCorpus15.85
WholeBlood398.3
Wholebrain12.8
colon408.25
pineal_day15.46
pineal_night34.84
retina621.575
small_intestine404.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P157007
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.33 ± 0.75
Basal Forebrain5.55 ± 0.34
Basal Part of Pons4.74 ± 0.44
Cerebellar Cortex4.52 ± 0.38
Cerebellar Nuclei5.54 ± 0.47
Claustrum4.57 ± 1.02
Epithalamus6.76 ± 0.6
Frontal Lobe5.01 ± 0.64
Globus Pallidus7.25 ± 0.36
Hypothalamus5.75 ± 0.57
Insula5.5 ± 0.29
Limbic Lobe4.83 ± 0.9
Mesencephalon5.53 ± 0.83
Myelencephalon5.37 ± 0.49
Occipital Lobe4.64 ± 0.91
Parietal Lobe5.09 ± 0.88
Pontine Tegmentum5.37 ± 0.9
Striatum5.83 ± 0.65
Subthalamus5.23 ± 1.16
Temporal Lobe5.39 ± 0.7
Thalamus5.48 ± 0.71
White Matter4.96 ± 0.81
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
1810009M01RikCBCerebellum6.65
6.07
1810009M01RikCTXCerebral cortex8.35
4.96
1810009M01RikHIPHippocampal region7.37
6.21
1810009M01RikHPFHippocampal formation7.54
6.07
1810009M01RikHYHypothalamus9.16
5.56
1810009M01RikLSXLateral septal complex4.29
2.53
1810009M01RikMBMidbrain4.32
4
1810009M01RikMYMedulla6.53
6.53
1810009M01RikOLFOlfactory bulb15.3
9.44
1810009M01RikPPons4.84
4.54
1810009M01RikPALPallidum6.43
5.31
1810009M01RikRHPRetrohippocampal region7.29
5.35
1810009M01RiksAMYStriatum-like amygdalar nuclei6.13
3.49
1810009M01RikSTRStriatum5.61
3.41
1810009M01RikSTRdStriatum dorsal region3.66
2.65
1810009M01RikSTRvStriatum ventral region12.48
5.79
1810009M01RikTHThalamus5.84
5.81
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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