AutismKB 2.0

Annotation Detail for GRN


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Basic Information Top
Gene Symbol:GRN ( GEP,GP88,PCDGF,PEPI,PGRN )
Gene Full Name: granulin
Band: 17q21.31
Quick LinksEntrez ID:2896; OMIM: 138945; Uniprot ID:GRN_HUMAN; ENSEMBL ID: ENSG00000030582; HGNC ID: 4601
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst6 / 6231996
fetus101 / 564012179
neonate271 / 310978714
infant16 / 23620677
juvenile100 / 555561799
adult1492 / 1939121769
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor6 / 12794468
bladder carcinoma7 / 17475400
breast (mammary gland) tumor120 / 941781274
cervical tumor22 / 34366640
chondrosarcoma39 / 82823470
colorectal tumor69 / 114246603
esophageal tumor26 / 172901503
gastrointestinal tumor113 / 119369946
germ cell tumor378 / 2638451432
glioma146 / 1068831365
head and neck tumor82 / 136302601
kidney tumor59 / 68959855
leukemia66 / 95842688
liver tumor52 / 96359539
lung tumor58 / 103127562
lymphoma25 / 71755348
non-neoplasia588 / 972506046
normal3762 / 33603071119
ovarian tumor83 / 766821082
pancreatic tumor45 / 104616430
primitive neuroectodermal tumor of the CNS184 / 1256801464
prostate cancer49 / 102680477
retinoblastoma13 / 46356280
skin tumor112 / 124949896
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor63 / 90257698
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland48 / 331971445
ascites76 / 400151899
bladder42 / 297571411
blood346 / 1234782802
bone19 / 71655265
bone marrow13 / 48801266
brain893 / 1100989811
cervix39 / 48171809
connective tissue646 / 1492554328
ear1 / 1621261
embryonic tissue33 / 215722152
esophagus33 / 202091632
eye33 / 211054156
heart61 / 89626680
intestine258 / 2344721100
kidney213 / 2117771005
larynx1 / 2414541
liver77 / 207743370
lung336 / 336974997
lymph10 / 44270225
lymph node12 / 91610130
mammary gland142 / 153271926
mouth69 / 670521029
muscle14 / 107715129
nerve4 / 15768253
ovary102 / 102051999
pancreas75 / 214812349
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland6 / 16585361
placenta507 / 2808251805
prostate162 / 189345855
salivary gland20 / 20155992
skin189 / 210574897
spleen284 / 539525263
stomach70 / 96619724
testis165 / 330442499
thymus140 / 811311725
thyroid54 / 474731137
tonsil4 / 16999235
trachea51 / 52413973
umbilical cord27 / 136801973
uterus197 / 232878845
vascular84 / 517801622
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211284_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts447.75
Adipocyte407.65
AdrenalCortex144.3
Adrenalgland190.25
Amygdala65.8
Appendix49.1
AtrioventricularNode61.25
BDCA4+_DentriticCells1945.35
Bonemarrow707.7
BronchialEpithelialCells736.75
CD105+_Endothelial114.45
CD14+_Monocytes2410.4
CD19+_BCells(neg._sel.)304.2
CD33+_Myeloid2882.05
CD34+273.25
CD4+_Tcells55.05
CD56+_NKCells130.7
CD71+_EarlyErythroid47
CD8+_Tcells28.1
CardiacMyocytes217.4
Caudatenucleus72.8
Cerebellum88.6
CerebellumPeduncles91.85
CiliaryGanglion85.1
CingulateCortex133.9
Colorectaladenocarcinoma310.55
DorsalRootGanglion78.75
FetalThyroid265.55
Fetalbrain68.35
Fetalliver70.85
Fetallung205.15
GlobusPallidus84.35
Heart613.15
Hypothalamus89.55
Kidney291.2
Leukemia_chronicMyelogenousK-562145.75
Leukemia_promyelocytic-HL-60694.65
Leukemialymphoblastic(MOLT-4)93.35
Liver478.75
Lung3645.15
Lymphnode611.55
Lymphoma_burkitts(Daudi)548
Lymphoma_burkitts(Raji)2035.4
MedullaOblongata39.85
OccipitalLobe87.35
OlfactoryBulb154.85
Ovary96.8
Pancreas217.1
PancreaticIslet398.2
ParietalLobe84.9
Pituitary213.2
Placenta1742
Pons65.8
PrefrontalCortex47.65
Prostate992.65
Salivarygland100.7
SkeletalMuscle95.75
Skin91.15
SmoothMuscle543.1
Spinalcord185.8
SubthalamicNucleus78.95
SuperiorCervicalGanglion49.65
TemporalLobe60.05
Testis165.1
TestisGermCell137.85
TestisIntersitial71.25
TestisLeydigCell144.6
TestisSeminiferousTubule172.05
Thalamus140.6
Thymus228.75
Thyroid434.7
Tongue384.15
Tonsil257.85
Trachea249.75
TrigeminalGanglion66.5
Uterus188.95
UterusCorpus173.15
WholeBlood1520.2
Wholebrain60.25
colon195.7
pineal_day177
pineal_night157.34
retina179.1
small_intestine128.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13046_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.09 ± 0.46
Basal Forebrain6.5 ± 0.16
Basal Part of Pons6.62 ± 0.41
Cerebellar Cortex6.58 ± 0.48
Cerebellar Nuclei6.69 ± 0.21
Claustrum6.16 ± 0.58
Epithalamus6.79 ± 0.54
Frontal Lobe6.65 ± 0.44
Globus Pallidus6.63 ± 0.35
Hypothalamus6.98 ± 0.61
Insula6.77 ± 0.3
Limbic Lobe6.27 ± 0.54
Mesencephalon6.53 ± 0.47
Myelencephalon6.56 ± 0.45
Occipital Lobe6.12 ± 0.43
Parietal Lobe6.35 ± 0.44
Pontine Tegmentum6.47 ± 0.52
Striatum6.17 ± 0.43
Subthalamus6.4 ± 0.12
Temporal Lobe6.66 ± 0.47
Thalamus6.56 ± 0.39
White Matter7.08 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GrnCBCerebellum13.44
12.32
GrnCTXCerebral cortex10.92
7.35
GrnHIPHippocampal region20.5
12.49
GrnHPFHippocampal formation18.66
11.48
GrnHYHypothalamus14.75
9.26
GrnLSXLateral septal complex5.33
4.57
GrnMBMidbrain9.03
6.82
GrnMYMedulla13.04
11.14
GrnOLFOlfactory bulb19.33
10.75
GrnPPons17.04
14.48
GrnPALPallidum12.39
8.65
GrnRHPRetrohippocampal region14.23
9.67
GrnsAMYStriatum-like amygdalar nuclei16.26
10.18
GrnSTRStriatum9.28
6.03
GrnSTRdStriatum dorsal region6.06
4
GrnSTRvStriatum ventral region20.58
12.11
GrnTHThalamus10.19
7.02
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009529 12 178 189 CITPTGTHPLAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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