AutismKB 2.0

Annotation Detail for GRIK1


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Basic Information Top
Gene Symbol:GRIK1 ( EAA3,EEA3,GLR5,GLUR5 )
Gene Full Name: glutamate receptor, ionotropic, kainate 1
Band: 21q21.3
Quick LinksEntrez ID:2897; OMIM: 138245; Uniprot ID:GRIK1_HUMAN; ENSEMBL ID: ENSG00000171189; HGNC ID: 4579
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult11 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal52 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain39 / 110098935
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214611_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.95
Adipocyte5.05
AdrenalCortex5.75
Adrenalgland4.45
Amygdala5.55
Appendix6.45
AtrioventricularNode4.75
BDCA4+_DentriticCells5.2
Bonemarrow5.35
BronchialEpithelialCells4.9
CD105+_Endothelial5.1
CD14+_Monocytes5.4
CD19+_BCells(neg._sel.)5.25
CD33+_Myeloid6.4
CD34+6.3
CD4+_Tcells5.3
CD56+_NKCells5.8
CD71+_EarlyErythroid4.9
CD8+_Tcells4.7
CardiacMyocytes9.45
Caudatenucleus4.6
Cerebellum4.2
CerebellumPeduncles6.15
CiliaryGanglion4.5
CingulateCortex5.35
Colorectaladenocarcinoma5.15
DorsalRootGanglion4.15
FetalThyroid5
Fetalbrain5
Fetalliver4.55
Fetallung4.05
GlobusPallidus3.9
Heart7.1
Hypothalamus5.5
Kidney4.4
Leukemia_chronicMyelogenousK-5624.65
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)4
Liver7.15
Lung5.55
Lymphnode4.3
Lymphoma_burkitts(Daudi)6.8
Lymphoma_burkitts(Raji)7.55
MedullaOblongata4.7
OccipitalLobe4.6
OlfactoryBulb4
Ovary3.8
Pancreas4.2
PancreaticIslet5.55
ParietalLobe5.6
Pituitary5.9
Placenta4.95
Pons5.05
PrefrontalCortex6.3
Prostate5.85
Salivarygland4.15
SkeletalMuscle6.5
Skin5.2
SmoothMuscle5.7
Spinalcord5.5
SubthalamicNucleus4.85
SuperiorCervicalGanglion8.25
TemporalLobe4.75
Testis4.35
TestisGermCell4.1
TestisIntersitial4.35
TestisLeydigCell5.15
TestisSeminiferousTubule4.35
Thalamus5.35
Thymus3.95
Thyroid6.3
Tongue5.6
Tonsil5
Trachea4.25
TrigeminalGanglion6.35
Uterus4.05
UterusCorpus4.8
WholeBlood5.5
Wholebrain4.2
colon5.15
pineal_day6.38
pineal_night6.24
retina6.1
small_intestine4.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1424_PI417557136
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.74 ± 0.55
Basal Forebrain6.54 ± 0.25
Basal Part of Pons8.49 ± 0.24
Cerebellar Cortex6.41 ± 0.83
Cerebellar Nuclei5.6 ± 0.55
Claustrum5.63 ± 0.63
Epithalamus6.58 ± 0.64
Frontal Lobe7.14 ± 0.95
Globus Pallidus5.49 ± 0.91
Hypothalamus7.08 ± 0.88
Insula7.51 ± 0.46
Limbic Lobe7.06 ± 0.94
Mesencephalon6.94 ± 0.84
Myelencephalon7.03 ± 0.92
Occipital Lobe6.55 ± 0.69
Parietal Lobe7.21 ± 0.58
Pontine Tegmentum6.65 ± 0.78
Striatum6.52 ± 0.92
Subthalamus5.88 ± 0.55
Temporal Lobe7.22 ± 0.46
Thalamus7.74 ± 0.46
White Matter4.61 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grik1CBCerebellum22.94
67.54
Grik1CTXCerebral cortex42.39
32.57
Grik1HIPHippocampal region24.59
30.28
Grik1HPFHippocampal formation40.23
43.75
Grik1HYHypothalamus66.88
55.4
Grik1LSXLateral septal complex56.09
41.93
Grik1MBMidbrain41.91
34.56
Grik1MYMedulla35.82
38.5
Grik1OLFOlfactory bulb81.98
71.75
Grik1PPons41.66
42.3
Grik1PALPallidum53.95
55.35
Grik1RHPRetrohippocampal region61.96
58.54
Grik1sAMYStriatum-like amygdalar nuclei69.69
65.35
Grik1STRStriatum17.06
14.59
Grik1STRdStriatum dorsal region4.12
3.76
Grik1STRvStriatum ventral region19.58
14.88
Grik1THThalamus60.98
50.02
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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