AutismKB 2.0

Annotation Detail for GRIK2


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Basic Information Top
Gene Symbol:GRIK2 ( EAA4,GLR6,GLUK6,GLUR6,MGC74427,MRT6 )
Gene Full Name: glutamate receptor, ionotropic, kainate 2
Band: 6q16.3
Quick LinksEntrez ID:2898; OMIM: 138244; Uniprot ID:GRIK2_HUMAN; ENSEMBL ID: ENSG00000164418; HGNC ID: 4580
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant1 / 2362042
juvenile4 / 5555671
adult11 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal44 / 336030713
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain25 / 110098922
cervix0 / 481710 
connective tissue0 / 1492550 
ear2 / 16212123
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine0 / 2344720 
kidney6 / 21177728
larynx0 / 241450 
liver1 / 2077434
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve3 / 15768190
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213845_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte6.25
AdrenalCortex13.3
Adrenalgland8.7
Amygdala25.6
Appendix6.4
AtrioventricularNode5.75
BDCA4+_DentriticCells5.2
Bonemarrow6.3
BronchialEpithelialCells4.5
CD105+_Endothelial6.5
CD14+_Monocytes5.75
CD19+_BCells(neg._sel.)6.6
CD33+_Myeloid7.05
CD34+7.35
CD4+_Tcells6.25
CD56+_NKCells7.35
CD71+_EarlyErythroid5.9
CD8+_Tcells5.4
CardiacMyocytes8.35
Caudatenucleus34.7
Cerebellum25.55
CerebellumPeduncles37.75
CiliaryGanglion15.9
CingulateCortex24.75
Colorectaladenocarcinoma5.55
DorsalRootGanglion14.6
FetalThyroid7.45
Fetalbrain45.3
Fetalliver5.25
Fetallung4.6
GlobusPallidus19.45
Heart8.95
Hypothalamus25.85
Kidney5.2
Leukemia_chronicMyelogenousK-5625.95
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)5.9
Liver7.75
Lung6.15
Lymphnode5.35
Lymphoma_burkitts(Daudi)7.7
Lymphoma_burkitts(Raji)10.15
MedullaOblongata15.35
OccipitalLobe43.65
OlfactoryBulb11.15
Ovary4.3
Pancreas4.95
PancreaticIslet6.4
ParietalLobe15.85
Pituitary12.3
Placenta5.9
Pons18.35
PrefrontalCortex40.45
Prostate6.75
Salivarygland5.65
SkeletalMuscle7.7
Skin5
SmoothMuscle7.15
Spinalcord8.55
SubthalamicNucleus21.35
SuperiorCervicalGanglion8.05
TemporalLobe19.05
Testis5.2
TestisGermCell4.75
TestisIntersitial6.4
TestisLeydigCell6.1
TestisSeminiferousTubule6.65
Thalamus17
Thymus3.8
Thyroid7.4
Tongue7.7
Tonsil9.4
Trachea5.25
TrigeminalGanglion17.35
Uterus4.7
UterusCorpus5.95
WholeBlood5.65
Wholebrain7.3
colon5.95
pineal_day56.24
pineal_night71.72
retina7.2
small_intestine5.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_406_PI417557136
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.42 ± 0.31
Basal Forebrain7.38 ± 0.61
Basal Part of Pons6.83 ± 0.35
Cerebellar Cortex7.63 ± 0.2
Cerebellar Nuclei5.97 ± 0.67
Claustrum7.82 ± 0.35
Epithalamus6.44 ± 0.66
Frontal Lobe6.8 ± 0.52
Globus Pallidus5.64 ± 0.59
Hypothalamus7.18 ± 0.93
Insula7.27 ± 0.41
Limbic Lobe7.37 ± 0.5
Mesencephalon6.91 ± 0.67
Myelencephalon6.92 ± 0.63
Occipital Lobe7.08 ± 0.51
Parietal Lobe6.92 ± 0.53
Pontine Tegmentum6.88 ± 0.74
Striatum6.77 ± 0.41
Subthalamus7.39 ± 0.16
Temporal Lobe7.14 ± 0.4
Thalamus6.66 ± 0.52
White Matter4.62 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grik2CBCerebellum100
100
Grik2CTXCerebral cortex78.61
62.44
Grik2HIPHippocampal region94.69
100
Grik2HPFHippocampal formation94.17
100
Grik2HYHypothalamus100
89.76
Grik2LSXLateral septal complex91.32
68.01
Grik2MBMidbrain80.79
69.55
Grik2MYMedulla56.81
60.99
Grik2OLFOlfactory bulb100
100
Grik2PPons44.78
41.12
Grik2PALPallidum94.91
94.44
Grik2RHPRetrohippocampal region96.04
88.63
Grik2sAMYStriatum-like amygdalar nuclei100
100
Grik2STRStriatum100
100
Grik2STRdStriatum dorsal region100
100
Grik2STRvStriatum ventral region100
100
Grik2THThalamus86
72.46
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GRIK2_HUMAN_846 10 846 855 SKKNAQLEKR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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