AutismKB 2.0

Annotation Detail for HIPK2


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Basic Information Top
Gene Symbol:HIPK2 ( DKFZp686K02111,FLJ23711,PRO0593 )
Gene Full Name: homeodomain interacting protein kinase 2
Band: 7q34
Quick LinksEntrez ID:28996; OMIM: 606868; Uniprot ID:HIPK2_HUMAN; ENSEMBL ID: ENSG00000064393; HGNC ID: 14402
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst4 / 6231964
fetus53 / 56401293
neonate0 / 310970 
infant5 / 23620211
juvenile0 / 555560 
adult230 / 1939121118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor13 / 94178138
cervical tumor1 / 3436629
chondrosarcoma10 / 82823120
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor9 / 26384534
glioma24 / 106883224
head and neck tumor10 / 13630273
kidney tumor14 / 68959203
leukemia18 / 95842187
liver tumor3 / 9635931
lung tumor12 / 103127116
lymphoma0 / 717550 
non-neoplasia14 / 97250143
normal345 / 3360307102
ovarian tumor3 / 7668239
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer5 / 10268048
retinoblastoma4 / 4635686
skin tumor8 / 12494964
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites3 / 4001574
bladder5 / 29757168
blood11 / 12347889
bone7 / 7165597
bone marrow3 / 4880161
brain217 / 1100989197
cervix1 / 4817120
connective tissue11 / 14925573
ear1 / 1621261
embryonic tissue18 / 21572283
esophagus1 / 2020949
eye28 / 211054132
heart10 / 89626111
intestine16 / 23447268
kidney24 / 211777113
larynx5 / 24145207
liver7 / 20774333
lung26 / 33697477
lymph0 / 442700 
lymph node6 / 9161065
mammary gland17 / 153271110
mouth4 / 6705259
muscle11 / 107715102
nerve1 / 1576863
ovary1 / 1020519
pancreas33 / 214812153
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta9 / 28082532
prostate14 / 18934573
salivary gland0 / 201550 
skin18 / 21057485
spleen2 / 5395237
stomach7 / 9661972
testis5 / 33044215
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus11 / 23287847
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219028_at
Cell line Expression level Expression bar
721_B_lymphoblasts39.15
Adipocyte38.25
AdrenalCortex69.3
Adrenalgland35.55
Amygdala39.7
Appendix40.25
AtrioventricularNode47.05
BDCA4+_DentriticCells24.6
Bonemarrow44.7
BronchialEpithelialCells25.2
CD105+_Endothelial26.6
CD14+_Monocytes32
CD19+_BCells(neg._sel.)28.5
CD33+_Myeloid34.75
CD34+29.15
CD4+_Tcells36.3
CD56+_NKCells40.9
CD71+_EarlyErythroid27.55
CD8+_Tcells29.95
CardiacMyocytes79.25
Caudatenucleus26.3
Cerebellum39.95
CerebellumPeduncles114.85
CiliaryGanglion41.45
CingulateCortex200.3
Colorectaladenocarcinoma26.75
DorsalRootGanglion50.25
FetalThyroid52.45
Fetalbrain30.55
Fetalliver25.15
Fetallung17.4
GlobusPallidus119.55
Heart70.5
Hypothalamus53.5
Kidney53.7
Leukemia_chronicMyelogenousK-56229.3
Leukemia_promyelocytic-HL-6022.75
Leukemialymphoblastic(MOLT-4)20.85
Liver58.6
Lung34.4
Lymphnode22.3
Lymphoma_burkitts(Daudi)40.85
Lymphoma_burkitts(Raji)41.9
MedullaOblongata254.95
OccipitalLobe111.2
OlfactoryBulb86.35
Ovary22.55
Pancreas46.45
PancreaticIslet56.2
ParietalLobe328.8
Pituitary63.85
Placenta32.45
Pons161.6
PrefrontalCortex456.4
Prostate41.75
Salivarygland25.75
SkeletalMuscle85.25
Skin34.75
SmoothMuscle32.3
Spinalcord50.95
SubthalamicNucleus86.65
SuperiorCervicalGanglion79.2
TemporalLobe159.2
Testis25.35
TestisGermCell19.6
TestisIntersitial20.45
TestisLeydigCell35.9
TestisSeminiferousTubule47.5
Thalamus48.25
Thymus19.9
Thyroid28.35
Tongue51.65
Tonsil30.4
Trachea24.8
TrigeminalGanglion43.15
Uterus30.35
UterusCorpus33.95
WholeBlood32.75
Wholebrain50.05
colon43.85
pineal_day213.14
pineal_night181.94
retina330.05
small_intestine40.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P738061
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.01 ± 1.11
Basal Forebrain1.67 ± 0.3
Basal Part of Pons1.27 ± 0.63
Cerebellar Cortex1.46 ± 0.74
Cerebellar Nuclei1.79 ± 0.73
Claustrum2.44 ± 0.93
Epithalamus1.48 ± 0.73
Frontal Lobe1.57 ± 0.85
Globus Pallidus2.29 ± 0.77
Hypothalamus1.69 ± 0.91
Insula1.44 ± 0.73
Limbic Lobe1.71 ± 0.88
Mesencephalon1.89 ± 0.83
Myelencephalon1.74 ± 0.78
Occipital Lobe1.7 ± 0.78
Parietal Lobe1.7 ± 0.92
Pontine Tegmentum1.75 ± 0.84
Striatum2 ± 0.89
Subthalamus1.49 ± 0.76
Temporal Lobe1.62 ± 0.83
Thalamus1.65 ± 0.68
White Matter1.78 ± 0.5
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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