AutismKB 2.0

Annotation Detail for GRIN1


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Basic Information Top
Gene Symbol:GRIN1 ( NMDA1,NMDAR1,NR1 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1
Band: 9q34.3
Quick LinksEntrez ID:2902; OMIM: 138249; Uniprot ID:NMDZ1_HUMAN; ENSEMBL ID: ENSG00000176884; HGNC ID: 4584
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult43 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal65 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain50 / 110098945
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye12 / 21105456
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205914_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.9
Adipocyte7.05
AdrenalCortex8.1
Adrenalgland10.65
Amygdala30.75
Appendix6.05
AtrioventricularNode4.8
BDCA4+_DentriticCells5.9
Bonemarrow15.3
BronchialEpithelialCells5.9
CD105+_Endothelial5.95
CD14+_Monocytes6
CD19+_BCells(neg._sel.)6.1
CD33+_Myeloid7.35
CD34+7.45
CD4+_Tcells6.05
CD56+_NKCells6.3
CD71+_EarlyErythroid6.6
CD8+_Tcells5.1
CardiacMyocytes7.6
Caudatenucleus25.55
Cerebellum8.45
CerebellumPeduncles6.8
CiliaryGanglion4.35
CingulateCortex15.2
Colorectaladenocarcinoma5.65
DorsalRootGanglion5.85
FetalThyroid5.75
Fetalbrain11.9
Fetalliver5.95
Fetallung4.9
GlobusPallidus20.2
Heart7.6
Hypothalamus14.9
Kidney6.85
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)5.1
Liver17.6
Lung9.05
Lymphnode5.1
Lymphoma_burkitts(Daudi)10.75
Lymphoma_burkitts(Raji)8.7
MedullaOblongata12.4
OccipitalLobe5.3
OlfactoryBulb6.2
Ovary4.25
Pancreas10.75
PancreaticIslet6.4
ParietalLobe8.55
Pituitary11.25
Placenta6.05
Pons6.75
PrefrontalCortex74.5
Prostate6.95
Salivarygland4.85
SkeletalMuscle6.95
Skin6.65
SmoothMuscle6.4
Spinalcord9.75
SubthalamicNucleus28.95
SuperiorCervicalGanglion6.85
TemporalLobe8.05
Testis5.9
TestisGermCell4.55
TestisIntersitial4.9
TestisLeydigCell5.6
TestisSeminiferousTubule5.05
Thalamus12.6
Thymus4.75
Thyroid6.5
Tongue5.6
Tonsil5.55
Trachea7.45
TrigeminalGanglion6.05
Uterus5.55
UterusCorpus5.1
WholeBlood6.05
Wholebrain9.15
colon5.35
pineal_day7.22
pineal_night7.12
retina6.625
small_intestine5.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P257962
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.4 ± 0.75
Basal Forebrain3.65 ± 0.44
Basal Part of Pons3.77 ± 0.42
Cerebellar Cortex3.44 ± 0.59
Cerebellar Nuclei3.43 ± 0.34
Claustrum4.28 ± 0.81
Epithalamus2.95 ± 1.09
Frontal Lobe3.95 ± 0.55
Globus Pallidus2.93 ± 1.05
Hypothalamus3.31 ± 0.76
Insula3.88 ± 0.34
Limbic Lobe4.23 ± 0.58
Mesencephalon3.84 ± 0.58
Myelencephalon3.88 ± 0.67
Occipital Lobe3.94 ± 0.68
Parietal Lobe3.9 ± 0.64
Pontine Tegmentum3.94 ± 0.67
Striatum4.35 ± 0.53
Subthalamus3.01 ± 0.69
Temporal Lobe3.93 ± 0.62
Thalamus3.72 ± 0.6
White Matter2.75 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grin1CBCerebellum99.66
94.12
Grin1CTXCerebral cortex100
100
Grin1HIPHippocampal region100
100
Grin1HPFHippocampal formation100
100
Grin1HYHypothalamus100
98.03
Grin1LSXLateral septal complex100
100
Grin1MBMidbrain100
100
Grin1MYMedulla100
100
Grin1OLFOlfactory bulb100
100
Grin1PPons96.55
100
Grin1PALPallidum100
100
Grin1RHPRetrohippocampal region100
100
Grin1sAMYStriatum-like amygdalar nuclei100
100
Grin1STRStriatum100
100
Grin1STRdStriatum dorsal region100
100
Grin1STRvStriatum ventral region100
100
Grin1THThalamus98.28
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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