AutismKB 2.0

Annotation Detail for GRIN2A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GRIN2A ( NMDAR2A,NR2A )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Band: 16p13.2
Quick LinksEntrez ID:2903; OMIM: 138253; Uniprot ID:NMDE1_HUMAN; ENSEMBL ID: ENSG00000183454; HGNC ID: 4585
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus1 / 5640121
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal90 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow0 / 488010 
brain44 / 110098939
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine0 / 2344720 
kidney9 / 21177742
larynx0 / 241450 
liver2 / 2077439
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis7 / 33044221
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206534_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.2
Adipocyte3.25
AdrenalCortex3.45
Adrenalgland2.8
Amygdala3.55
Appendix3.45
AtrioventricularNode2.5
BDCA4+_DentriticCells3.7
Bonemarrow3.25
BronchialEpithelialCells3.25
CD105+_Endothelial3.35
CD14+_Monocytes3.55
CD19+_BCells(neg._sel.)3.6
CD33+_Myeloid4.3
CD34+4.2
CD4+_Tcells3.6
CD56+_NKCells4
CD71+_EarlyErythroid3.1
CD8+_Tcells3.2
CardiacMyocytes4.2
Caudatenucleus2.95
Cerebellum2.7
CerebellumPeduncles3.75
CiliaryGanglion2.35
CingulateCortex7.05
Colorectaladenocarcinoma3.35
DorsalRootGanglion2.5
FetalThyroid3.25
Fetalbrain3.35
Fetalliver2.85
Fetallung2.8
GlobusPallidus2.95
Heart4.2
Hypothalamus3.6
Kidney2.7
Leukemia_chronicMyelogenousK-5623
Leukemia_promyelocytic-HL-602.9
Leukemialymphoblastic(MOLT-4)2.7
Liver4.35
Lung3.65
Lymphnode2.9
Lymphoma_burkitts(Daudi)4.2
Lymphoma_burkitts(Raji)4.65
MedullaOblongata6.5
OccipitalLobe5.85
OlfactoryBulb2.65
Ovary2.2
Pancreas2.65
PancreaticIslet3.5
ParietalLobe7.45
Pituitary3.9
Placenta3.45
Pons6.3
PrefrontalCortex4.55
Prostate3.85
Salivarygland2.65
SkeletalMuscle5.1
Skin2.55
SmoothMuscle3.75
Spinalcord3.55
SubthalamicNucleus12.6
SuperiorCervicalGanglion3.8
TemporalLobe5.85
Testis2.85
TestisGermCell2.8
TestisIntersitial2.8
TestisLeydigCell3.25
TestisSeminiferousTubule2.9
Thalamus3.35
Thymus2.6
Thyroid4.15
Tongue3.25
Tonsil3.25
Trachea2.8
TrigeminalGanglion3.45
Uterus2.7
UterusCorpus2.95
WholeBlood3.65
Wholebrain2.9
colon3.35
pineal_day4.14
pineal_night4.08
retina4.025
small_intestine3.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_312_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.53 ± 0.85
Basal Forebrain5.58 ± 0.87
Basal Part of Pons5.54 ± 0.49
Cerebellar Cortex6.32 ± 0.24
Cerebellar Nuclei5.04 ± 0.55
Claustrum6 ± 0.62
Epithalamus6.27 ± 0.69
Frontal Lobe6.43 ± 0.64
Globus Pallidus4.14 ± 0.85
Hypothalamus5.15 ± 0.53
Insula6.48 ± 0.52
Limbic Lobe6.92 ± 0.61
Mesencephalon5.98 ± 0.74
Myelencephalon6.19 ± 0.74
Occipital Lobe6.71 ± 0.51
Parietal Lobe6.66 ± 0.71
Pontine Tegmentum6.51 ± 0.86
Striatum5.1 ± 1.04
Subthalamus5.84 ± 0.5
Temporal Lobe6.71 ± 0.48
Thalamus6.13 ± 0.57
White Matter4.37 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grin2aCBCerebellum5.17
7.23
Grin2aCTXCerebral cortex45.53
26.78
Grin2aHIPHippocampal region71.39
86.87
Grin2aHPFHippocampal formation58.88
69.69
Grin2aHYHypothalamus1.51
1.88
Grin2aLSXLateral septal complex2.42
1.3
Grin2aMBMidbrain3.77
3.94
Grin2aMYMedulla1.99
1.68
Grin2aOLFOlfactory bulb26.62
14.61
Grin2aPPons1.33
1.4
Grin2aPALPallidum0.95
0.78
Grin2aRHPRetrohippocampal region40.96
26.21
Grin2asAMYStriatum-like amygdalar nuclei3.33
2.23
Grin2aSTRStriatum5.21
3.41
Grin2aSTRdStriatum dorsal region5.46
3.66
Grin2aSTRvStriatum ventral region6.31
3.85
Grin2aTHThalamus8.29
7.71
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved