AutismKB 2.0

Annotation Detail for ZCCHC4


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Basic Information Top
Gene Symbol:ZCCHC4 ( HSPC052,MGC21108 )
Gene Full Name: zinc finger, CCHC domain containing 4
Band: 4p15.2
Quick LinksEntrez ID:29063; OMIM: 611792; Uniprot ID:ZCHC4_HUMAN; ENSEMBL ID: ENSG00000168228; HGNC ID: 22917
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus10 / 56401217
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult16 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal32 / 33603079
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow1 / 4880120
brain10 / 11009899
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine2 / 2344728
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node2 / 9161021
mammary gland3 / 15327119
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland2 / 2015599
skin2 / 2105749
spleen0 / 539520 
stomach1 / 9661910
testis6 / 33044218
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220473_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.8
Adipocyte6.95
AdrenalCortex9
Adrenalgland6.85
Amygdala7
Appendix11.1
AtrioventricularNode8.3
BDCA4+_DentriticCells7
Bonemarrow7.7
BronchialEpithelialCells6.75
CD105+_Endothelial6.95
CD14+_Monocytes7.55
CD19+_BCells(neg._sel.)7.2
CD33+_Myeloid8.55
CD34+8
CD4+_Tcells7
CD56+_NKCells7.45
CD71+_EarlyErythroid6.85
CD8+_Tcells6.15
CardiacMyocytes12.4
Caudatenucleus6.35
Cerebellum5.85
CerebellumPeduncles9.5
CiliaryGanglion6.85
CingulateCortex7.5
Colorectaladenocarcinoma6.9
DorsalRootGanglion6.9
FetalThyroid7.55
Fetalbrain6.6
Fetalliver6.3
Fetallung5.95
GlobusPallidus5.8
Heart12.4
Hypothalamus7.1
Kidney6.55
Leukemia_chronicMyelogenousK-5626.3
Leukemia_promyelocytic-HL-606.25
Leukemialymphoblastic(MOLT-4)5.6
Liver12.8
Lung7.65
Lymphnode5.75
Lymphoma_burkitts(Daudi)9.45
Lymphoma_burkitts(Raji)11.55
MedullaOblongata6.4
OccipitalLobe6.25
OlfactoryBulb5.4
Ovary5.55
Pancreas6.6
PancreaticIslet8.15
ParietalLobe8.35
Pituitary8.2
Placenta6.95
Pons7.15
PrefrontalCortex8.25
Prostate7.95
Salivarygland6
SkeletalMuscle10.7
Skin7
SmoothMuscle7.9
Spinalcord7.25
SubthalamicNucleus7.65
SuperiorCervicalGanglion12.05
TemporalLobe6.9
Testis5.95
TestisGermCell5.55
TestisIntersitial6.1
TestisLeydigCell7.35
TestisSeminiferousTubule5.9
Thalamus7.4
Thymus5.05
Thyroid8.35
Tongue8.3
Tonsil7
Trachea5.85
TrigeminalGanglion9.05
Uterus5.55
UterusCorpus7.25
WholeBlood7.45
Wholebrain5.55
colon6.7
pineal_day8.54
pineal_night8.26
retina8.25
small_intestine6.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P155807
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.78 ± 0.74
Basal Forebrain3.49 ± 0.43
Basal Part of Pons3.5 ± 0.49
Cerebellar Cortex4.07 ± 0.36
Cerebellar Nuclei3.68 ± 0.55
Claustrum3.69 ± 0.47
Epithalamus3.86 ± 0.62
Frontal Lobe3.41 ± 0.62
Globus Pallidus4.12 ± 0.79
Hypothalamus3.39 ± 0.68
Insula3.28 ± 0.53
Limbic Lobe3.4 ± 0.65
Mesencephalon3.82 ± 0.7
Myelencephalon3.55 ± 0.68
Occipital Lobe4 ± 0.56
Parietal Lobe3.66 ± 0.67
Pontine Tegmentum3.5 ± 0.54
Striatum3.34 ± 0.77
Subthalamus3.85 ± 0.24
Temporal Lobe3.43 ± 0.66
Thalamus3.62 ± 0.56
White Matter4.75 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zcchc4CBCerebellum0.92
1.1
Zcchc4CTXCerebral cortex0.27
0.31
Zcchc4HIPHippocampal region0.15
0.14
Zcchc4HPFHippocampal formation0.17
0.23
Zcchc4HYHypothalamus0.13
0.2
Zcchc4LSXLateral septal complex0.03
0
Zcchc4MBMidbrain0.2
0.3
Zcchc4MYMedulla1.31
2.03
Zcchc4OLFOlfactory bulb0.54
0.59
Zcchc4PPons0.34
0.86
Zcchc4PALPallidum0.07
0.19
Zcchc4RHPRetrohippocampal region0.27
0.54
Zcchc4sAMYStriatum-like amygdalar nuclei0.11
0.24
Zcchc4STRStriatum0.12
0.12
Zcchc4STRdStriatum dorsal region0.14
0.13
Zcchc4STRvStriatum ventral region0.07
0.04
Zcchc4THThalamus0.2
0.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00519216 15 6 20 NGFEAVEAEGSAGCR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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