AutismKB 2.0

Annotation Detail for MED4


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Basic Information Top
Gene Symbol:MED4 ( ARC36,DRIP36,FLJ10956,HSPC126,TRAP36,VDRIP )
Gene Full Name: mediator complex subunit 4
Band: 13q14.2
Quick LinksEntrez ID:29079; OMIM: 605718; Uniprot ID:MED4_HUMAN; ENSEMBL ID: ENSG00000136146; HGNC ID: 17903
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus29 / 56401251
neonate0 / 310970 
infant4 / 23620169
juvenile1 / 5555617
adult168 / 193912186
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma14 / 17475801
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor15 / 119369125
germ cell tumor30 / 263845113
glioma9 / 10688384
head and neck tumor9 / 13630266
kidney tumor7 / 68959101
leukemia14 / 95842146
liver tumor9 / 9635993
lung tumor2 / 10312719
lymphoma4 / 7175555
non-neoplasia3 / 9725030
normal236 / 336030770
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer13 / 102680126
retinoblastoma3 / 4635664
skin tumor2 / 12494916
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites6 / 40015149
bladder14 / 29757470
blood8 / 12347864
bone10 / 71655139
bone marrow17 / 48801348
brain64 / 110098958
cervix4 / 4817183
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus1 / 2020949
eye9 / 21105442
heart1 / 8962611
intestine20 / 23447285
kidney35 / 211777165
larynx1 / 2414541
liver14 / 20774367
lung14 / 33697441
lymph1 / 4427022
lymph node3 / 9161032
mammary gland18 / 153271117
mouth4 / 6705259
muscle6 / 10771555
nerve0 / 157680 
ovary7 / 10205168
pancreas2 / 2148129
parathyroid1 / 2053948
pharynx9 / 41328217
pituitary gland1 / 1658560
placenta26 / 28082592
prostate15 / 18934579
salivary gland2 / 2015599
skin4 / 21057418
spleen5 / 5395292
stomach13 / 96619134
testis39 / 330442118
thymus2 / 8113124
thyroid5 / 47473105
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus17 / 23287872
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217843_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts22.9
Adipocyte13.65
AdrenalCortex21.35
Adrenalgland12.2
Amygdala36.6
Appendix16.1
AtrioventricularNode12.5
BDCA4+_DentriticCells23.5
Bonemarrow15.75
BronchialEpithelialCells18.85
CD105+_Endothelial17.55
CD14+_Monocytes37.2
CD19+_BCells(neg._sel.)26
CD33+_Myeloid24.1
CD34+42.2
CD4+_Tcells30.15
CD56+_NKCells44.55
CD71+_EarlyErythroid22
CD8+_Tcells28.95
CardiacMyocytes27.8
Caudatenucleus11.85
Cerebellum10.35
CerebellumPeduncles17.55
CiliaryGanglion13.4
CingulateCortex14.45
Colorectaladenocarcinoma36.15
DorsalRootGanglion13.3
FetalThyroid16.25
Fetalbrain13.65
Fetalliver13.4
Fetallung16.65
GlobusPallidus11.5
Heart24.4
Hypothalamus15.9
Kidney13.1
Leukemia_chronicMyelogenousK-5629.9
Leukemia_promyelocytic-HL-6020.2
Leukemialymphoblastic(MOLT-4)23.05
Liver16.85
Lung13.95
Lymphnode19.15
Lymphoma_burkitts(Daudi)19.15
Lymphoma_burkitts(Raji)25.3
MedullaOblongata11.85
OccipitalLobe12
OlfactoryBulb11.3
Ovary11.2
Pancreas11.7
PancreaticIslet18.9
ParietalLobe15.75
Pituitary16.4
Placenta13.55
Pons13.25
PrefrontalCortex27.7
Prostate17.85
Salivarygland18
SkeletalMuscle16.95
Skin15.85
SmoothMuscle16.9
Spinalcord16.05
SubthalamicNucleus14.65
SuperiorCervicalGanglion25.75
TemporalLobe14.1
Testis12.05
TestisGermCell16.6
TestisIntersitial18.35
TestisLeydigCell16.65
TestisSeminiferousTubule12.8
Thalamus14.85
Thymus13.15
Thyroid30.55
Tongue17.55
Tonsil14.1
Trachea11.35
TrigeminalGanglion19.75
Uterus32.5
UterusCorpus10.7
WholeBlood52.45
Wholebrain11.15
colon25.4
pineal_day41.94
pineal_night23.4
retina16.15
small_intestine21.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10257_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.91 ± 0.19
Basal Forebrain8.01 ± 0.08
Basal Part of Pons8.03 ± 0.21
Cerebellar Cortex8.25 ± 0.22
Cerebellar Nuclei7.96 ± 0.28
Claustrum8.02 ± 0.27
Epithalamus7.85 ± 0.39
Frontal Lobe8.04 ± 0.29
Globus Pallidus7.96 ± 0.28
Hypothalamus8.13 ± 0.22
Insula8.08 ± 0.21
Limbic Lobe7.99 ± 0.3
Mesencephalon8.05 ± 0.25
Myelencephalon7.97 ± 0.3
Occipital Lobe7.79 ± 0.3
Parietal Lobe8.04 ± 0.25
Pontine Tegmentum8.01 ± 0.25
Striatum7.82 ± 0.22
Subthalamus8 ± 0.33
Temporal Lobe8.07 ± 0.24
Thalamus8.01 ± 0.25
White Matter8.46 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Med4CBCerebellum12.87
15.03
Med4CTXCerebral cortex31.16
22.34
Med4HIPHippocampal region21.02
21.96
Med4HPFHippocampal formation21.31
19.35
Med4HYHypothalamus13.48
10.06
Med4LSXLateral septal complex20.42
14.24
Med4MBMidbrain12.86
11.49
Med4MYMedulla31.91
35.66
Med4OLFOlfactory bulb30.23
22.46
Med4PPons23.19
24.35
Med4PALPallidum20.56
18.74
Med4RHPRetrohippocampal region22.33
16.03
Med4sAMYStriatum-like amygdalar nuclei22.76
15.17
Med4STRStriatum21
14.53
Med4STRdStriatum dorsal region19.17
13.53
Med4STRvStriatum ventral region27.91
17.98
Med4THThalamus18.64
14.84
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MED4_HUMAN_174 10 174 183 RPYPTDLEMR PRIDE
MED4_HUMAN_2 12 2 13 AASSSGEKEKER PRIDE
PAp00010515 19 155 173 ISASNAVCAPLTWVPGDPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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