AutismKB 2.0

Annotation Detail for NR3C1


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Basic Information Top
Gene Symbol:NR3C1 ( GCCR,GCR,GR,GRL )
Gene Full Name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Band: 5q31.3
Quick LinksEntrez ID:2908; OMIM: 138040; Uniprot ID:GCR_HUMAN; ENSEMBL ID: ENSG00000113580; HGNC ID: 7978
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus37 / 56401265
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult116 / 193912159
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma10 / 82823120
colorectal tumor0 / 1142460 
esophageal tumor2 / 17290115
gastrointestinal tumor1 / 1193698
germ cell tumor21 / 26384579
glioma6 / 10688356
head and neck tumor9 / 13630266
kidney tumor8 / 68959116
leukemia5 / 9584252
liver tumor10 / 96359103
lung tumor0 / 1031270 
lymphoma8 / 71755111
non-neoplasia3 / 9725030
normal266 / 336030779
ovarian tumor2 / 7668226
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood8 / 12347864
bone12 / 71655167
bone marrow2 / 4880140
brain58 / 110098952
cervix2 / 4817141
connective tissue15 / 149255100
ear1 / 1621261
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye7 / 21105433
heart5 / 8962655
intestine2 / 2344728
kidney23 / 211777108
larynx0 / 241450 
liver17 / 20774381
lung27 / 33697480
lymph3 / 4427067
lymph node13 / 91610141
mammary gland5 / 15327132
mouth5 / 6705274
muscle6 / 10771555
nerve2 / 15768126
ovary3 / 10205129
pancreas25 / 214812116
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland5 / 16585301
placenta28 / 28082599
prostate10 / 18934552
salivary gland1 / 2015549
skin9 / 21057442
spleen2 / 5395237
stomach2 / 9661920
testis19 / 33044257
thymus7 / 8113186
thyroid4 / 4747384
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus5 / 23287821
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211671_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts904.05
Adipocyte55.45
AdrenalCortex23.25
Adrenalgland12.65
Amygdala29.75
Appendix36.15
AtrioventricularNode23.95
BDCA4+_DentriticCells155.7
Bonemarrow24.05
BronchialEpithelialCells40.8
CD105+_Endothelial123.15
CD14+_Monocytes283.9
CD19+_BCells(neg._sel.)273.15
CD33+_Myeloid430.55
CD34+119.25
CD4+_Tcells218.55
CD56+_NKCells417.8
CD71+_EarlyErythroid113.65
CD8+_Tcells204.3
CardiacMyocytes65.2
Caudatenucleus21.4
Cerebellum26
CerebellumPeduncles50.3
CiliaryGanglion19.5
CingulateCortex41
Colorectaladenocarcinoma4.95
DorsalRootGanglion25.95
FetalThyroid58.35
Fetalbrain8.9
Fetalliver35.4
Fetallung28.8
GlobusPallidus50.8
Heart16.5
Hypothalamus25.95
Kidney16.55
Leukemia_chronicMyelogenousK-56216.55
Leukemia_promyelocytic-HL-6027.1
Leukemialymphoblastic(MOLT-4)12.75
Liver26.15
Lung27.05
Lymphnode24.65
Lymphoma_burkitts(Daudi)38.05
Lymphoma_burkitts(Raji)19.6
MedullaOblongata80.5
OccipitalLobe84.25
OlfactoryBulb115.45
Ovary12.05
Pancreas13.95
PancreaticIslet89.1
ParietalLobe47.95
Pituitary147.95
Placenta54.2
Pons46.25
PrefrontalCortex166.75
Prostate141.85
Salivarygland56.5
SkeletalMuscle38.15
Skin25.4
SmoothMuscle269.35
Spinalcord15.65
SubthalamicNucleus61.6
SuperiorCervicalGanglion38.75
TemporalLobe39.45
Testis8.7
TestisGermCell28.85
TestisIntersitial25.45
TestisLeydigCell15.7
TestisSeminiferousTubule16.95
Thalamus22.35
Thymus137.65
Thyroid30.4
Tongue32.5
Tonsil130.8
Trachea33.5
TrigeminalGanglion29.35
Uterus114.7
UterusCorpus22.25
WholeBlood176.8
Wholebrain43.15
colon48.3
pineal_day15.34
pineal_night17.88
retina83.325
small_intestine46.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P214059
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.76 ± 0.29
Basal Forebrain9.12 ± 0.19
Basal Part of Pons9.15 ± 0.29
Cerebellar Cortex9.53 ± 0.09
Cerebellar Nuclei9.17 ± 0.22
Claustrum9.01 ± 0.53
Epithalamus9.35 ± 0.3
Frontal Lobe9.22 ± 0.36
Globus Pallidus8.7 ± 0.28
Hypothalamus8.95 ± 0.37
Insula9.05 ± 0.29
Limbic Lobe8.75 ± 0.34
Mesencephalon9 ± 0.41
Myelencephalon9.18 ± 0.38
Occipital Lobe9.62 ± 0.29
Parietal Lobe9.28 ± 0.4
Pontine Tegmentum9.17 ± 0.42
Striatum8.5 ± 0.39
Subthalamus8.71 ± 0.23
Temporal Lobe9.01 ± 0.43
Thalamus9.55 ± 0.35
White Matter9.15 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nr3c1CBCerebellum28.66
22.14
Nr3c1CTXCerebral cortex45.63
28.98
Nr3c1HIPHippocampal region35.13
24.88
Nr3c1HPFHippocampal formation36.61
25.36
Nr3c1HYHypothalamus10.47
6.73
Nr3c1LSXLateral septal complex5.06
3.08
Nr3c1MBMidbrain7.09
5.86
Nr3c1MYMedulla5.62
4.72
Nr3c1OLFOlfactory bulb16.08
9.9
Nr3c1PPons5.35
5.3
Nr3c1PALPallidum4.71
3.22
Nr3c1RHPRetrohippocampal region39.47
26.52
Nr3c1sAMYStriatum-like amygdalar nuclei14.18
9.37
Nr3c1STRStriatum7.29
4.53
Nr3c1STRdStriatum dorsal region6.91
4.43
Nr3c1STRvStriatum ventral region6.51
3.19
Nr3c1THThalamus33.31
28.17
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GCR_HUMAN_1 11 1 11 MDSKESLTPGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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