AutismKB 2.0

Annotation Detail for METTL5


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Basic Information Top
Gene Symbol:METTL5 ( FLJ10459,HSPC133 )
Gene Full Name: methyltransferase like 5
Band: 2q31.1
Quick LinksEntrez ID:29081; OMIM: NA; Uniprot ID:METL5_HUMAN; ENSEMBL ID: ENSG00000138382; HGNC ID: 25006
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor7 / 26384526
glioma6 / 10688356
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal106 / 336030731
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer14 / 102680136
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood3 / 12347824
bone1 / 7165513
bone marrow4 / 4880181
brain36 / 110098932
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye9 / 21105442
heart3 / 8962633
intestine7 / 23447229
kidney2 / 2117779
larynx1 / 2414541
liver5 / 20774324
lung4 / 33697411
lymph0 / 442700 
lymph node8 / 9161087
mammary gland9 / 15327158
mouth0 / 670520 
muscle2 / 10771518
nerve1 / 1576863
ovary4 / 10205139
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta2 / 2808257
prostate15 / 18934579
salivary gland4 / 20155198
skin4 / 21057418
spleen0 / 539520 
stomach1 / 9661910
testis19 / 33044257
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221570_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1094.2
Adipocyte229.4
AdrenalCortex49.85
Adrenalgland66.55
Amygdala310.1
Appendix123.7
AtrioventricularNode59.65
BDCA4+_DentriticCells237.95
Bonemarrow76.75
BronchialEpithelialCells1422.8
CD105+_Endothelial684.9
CD14+_Monocytes232.85
CD19+_BCells(neg._sel.)333.8
CD33+_Myeloid184.95
CD34+431.75
CD4+_Tcells301.25
CD56+_NKCells261.1
CD71+_EarlyErythroid327.85
CD8+_Tcells249.5
CardiacMyocytes163.65
Caudatenucleus96.55
Cerebellum43.75
CerebellumPeduncles54
CiliaryGanglion65.7
CingulateCortex107.05
Colorectaladenocarcinoma763.7
DorsalRootGanglion95
FetalThyroid134.15
Fetalbrain132
Fetalliver192.15
Fetallung127.75
GlobusPallidus77.15
Heart106.15
Hypothalamus258.05
Kidney79.6
Leukemia_chronicMyelogenousK-562715.45
Leukemia_promyelocytic-HL-60646.65
Leukemialymphoblastic(MOLT-4)216.95
Liver142.3
Lung111.8
Lymphnode114.65
Lymphoma_burkitts(Daudi)399.2
Lymphoma_burkitts(Raji)596.15
MedullaOblongata97
OccipitalLobe143.8
OlfactoryBulb120.35
Ovary76.7
Pancreas384.75
PancreaticIslet430
ParietalLobe94.25
Pituitary205
Placenta84.8
Pons81.55
PrefrontalCortex125.45
Prostate135.6
Salivarygland108.65
SkeletalMuscle118.55
Skin51.7
SmoothMuscle394.2
Spinalcord168.7
SubthalamicNucleus98.75
SuperiorCervicalGanglion76.1
TemporalLobe102.4
Testis65.65
TestisGermCell87.4
TestisIntersitial58.7
TestisLeydigCell78.15
TestisSeminiferousTubule73.2
Thalamus90.6
Thymus63
Thyroid389.65
Tongue128
Tonsil84.4
Trachea110.1
TrigeminalGanglion79.1
Uterus183.6
UterusCorpus87.15
WholeBlood164.05
Wholebrain238.1
colon379.9
pineal_day304.58
pineal_night279.46
retina141.35
small_intestine175.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P142634
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.12 ± 0.2
Basal Forebrain9.02 ± 0.12
Basal Part of Pons9.22 ± 0.25
Cerebellar Cortex8.97 ± 0.24
Cerebellar Nuclei9.1 ± 0.16
Claustrum8.96 ± 0.34
Epithalamus9.34 ± 0.2
Frontal Lobe9.18 ± 0.25
Globus Pallidus9.06 ± 0.25
Hypothalamus9.39 ± 0.17
Insula9.32 ± 0.3
Limbic Lobe8.98 ± 0.34
Mesencephalon9.06 ± 0.28
Myelencephalon9.04 ± 0.29
Occipital Lobe8.8 ± 0.27
Parietal Lobe9.07 ± 0.27
Pontine Tegmentum9.09 ± 0.29
Striatum8.92 ± 0.33
Subthalamus9.19 ± 0.25
Temporal Lobe9.19 ± 0.24
Thalamus8.96 ± 0.24
White Matter8.93 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mettl5CBCerebellum10.42
12.6
Mettl5CTXCerebral cortex7.94
6.42
Mettl5HIPHippocampal region7.85
9.01
Mettl5HPFHippocampal formation7.56
7.63
Mettl5HYHypothalamus2.03
1.6
Mettl5LSXLateral septal complex1.53
4.1
Mettl5MBMidbrain2.6
3.27
Mettl5MYMedulla6.39
6.65
Mettl5OLFOlfactory bulb11.55
11.24
Mettl5PPons3.19
3.21
Mettl5PALPallidum2.02
1.81
Mettl5RHPRetrohippocampal region7.25
5.55
Mettl5sAMYStriatum-like amygdalar nuclei0.52
0.54
Mettl5STRStriatum1.94
1.79
Mettl5STRdStriatum dorsal region1.67
1.39
Mettl5STRvStriatum ventral region3.77
2.64
Mettl5THThalamus4.76
4.46
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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