AutismKB 2.0

Annotation Detail for DROSHA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DROSHA ( ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L,RNASEN )
Gene Full Name: drosha, ribonuclease type III
Band: 5p13.3
Quick LinksEntrez ID:29102; OMIM: 608828; Uniprot ID:RNC_HUMAN; ENSEMBL ID: ENSG00000113360; HGNC ID: 17904
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus36 / 56401263
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult132 / 193912168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor9 / 9417895
cervical tumor6 / 34366174
chondrosarcoma3 / 8282336
colorectal tumor7 / 11424661
esophageal tumor3 / 17290173
gastrointestinal tumor4 / 11936933
germ cell tumor18 / 26384568
glioma1 / 1068839
head and neck tumor16 / 136302117
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor3 / 9635931
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal139 / 336030741
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor35 / 125191279
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites1 / 4001524
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow5 / 48801102
brain63 / 110098957
cervix6 / 48171124
connective tissue31 / 149255207
ear3 / 16212185
embryonic tissue4 / 21572218
esophagus3 / 20209148
eye8 / 21105437
heart3 / 8962633
intestine12 / 23447251
kidney12 / 21177756
larynx1 / 2414541
liver6 / 20774328
lung15 / 33697444
lymph0 / 442700 
lymph node2 / 9161021
mammary gland15 / 15327197
mouth13 / 67052193
muscle6 / 10771555
nerve1 / 1576863
ovary4 / 10205139
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta7 / 28082524
prostate7 / 18934536
salivary gland1 / 2015549
skin8 / 21057437
spleen2 / 5395237
stomach3 / 9661931
testis25 / 33044275
thymus7 / 8113186
thyroid3 / 4747363
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus19 / 23287881
vascular7 / 51780135
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218269_at
Cell line Expression level Expression bar
721_B_lymphoblasts38.65
Adipocyte13.3
AdrenalCortex14.95
Adrenalgland11.3
Amygdala18.1
Appendix14
AtrioventricularNode11.5
BDCA4+_DentriticCells38.1
Bonemarrow13.75
BronchialEpithelialCells16.65
CD105+_Endothelial35.3
CD14+_Monocytes15.25
CD19+_BCells(neg._sel.)14.95
CD33+_Myeloid22.3
CD34+70.6
CD4+_Tcells24
CD56+_NKCells27.25
CD71+_EarlyErythroid12.85
CD8+_Tcells27.3
CardiacMyocytes20.05
Caudatenucleus12.95
Cerebellum11.7
CerebellumPeduncles16.25
CiliaryGanglion9.8
CingulateCortex14.6
Colorectaladenocarcinoma13.95
DorsalRootGanglion10.8
FetalThyroid18.95
Fetalbrain34.25
Fetalliver11.95
Fetallung11.45
GlobusPallidus10.15
Heart18.45
Hypothalamus24.35
Kidney11.3
Leukemia_chronicMyelogenousK-56241.35
Leukemia_promyelocytic-HL-6017.35
Leukemialymphoblastic(MOLT-4)26.5
Liver18.25
Lung12.95
Lymphnode11.4
Lymphoma_burkitts(Daudi)27.65
Lymphoma_burkitts(Raji)20.4
MedullaOblongata17.15
OccipitalLobe12.4
OlfactoryBulb13.5
Ovary9.1
Pancreas11.35
PancreaticIslet14.75
ParietalLobe13.25
Pituitary17.15
Placenta13.35
Pons12.7
PrefrontalCortex21.5
Prostate15.7
Salivarygland11.25
SkeletalMuscle15.9
Skin10.45
SmoothMuscle19.25
Spinalcord13.85
SubthalamicNucleus12.6
SuperiorCervicalGanglion17
TemporalLobe12.5
Testis11.05
TestisGermCell12.15
TestisIntersitial11
TestisLeydigCell12.05
TestisSeminiferousTubule12.05
Thalamus16
Thymus11.25
Thyroid17.25
Tongue14.25
Tonsil14.8
Trachea10.75
TrigeminalGanglion14
Uterus11.7
UterusCorpus12.05
WholeBlood13.95
Wholebrain12.5
colon19.35
pineal_day35.86
pineal_night37.28
retina16.5
small_intestine13.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P133596
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.07 ± 0.27
Basal Forebrain9.21 ± 0.13
Basal Part of Pons9.21 ± 0.23
Cerebellar Cortex9.46 ± 0.17
Cerebellar Nuclei9.26 ± 0.27
Claustrum9.13 ± 0.35
Epithalamus9.39 ± 0.28
Frontal Lobe9.28 ± 0.21
Globus Pallidus8.74 ± 0.18
Hypothalamus9.32 ± 0.28
Insula9.41 ± 0.27
Limbic Lobe9.02 ± 0.38
Mesencephalon9.2 ± 0.25
Myelencephalon9.15 ± 0.3
Occipital Lobe8.89 ± 0.35
Parietal Lobe9.18 ± 0.3
Pontine Tegmentum9.24 ± 0.29
Striatum9.12 ± 0.35
Subthalamus9.46 ± 0.08
Temporal Lobe9.28 ± 0.28
Thalamus9.2 ± 0.27
White Matter8.95 ± 0.19
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00500604 20 1076 1095 EVWLNYPLHPLQLQEPNTDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved