AutismKB 2.0

Annotation Detail for PYCARD


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Basic Information Top
Gene Symbol:PYCARD ( ASC,CARD5,MGC10332,TMS,TMS-1,TMS1 )
Gene Full Name: PYD and CARD domain containing
Band: 16p11.2
Quick LinksEntrez ID:29108; OMIM: 606838; Uniprot ID:ASC_HUMAN; ENSEMBL ID: ENSG00000103490; HGNC ID: 16608
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult28 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal34 / 336030710
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine10 / 23447242
kidney1 / 2117774
larynx1 / 2414541
liver1 / 2077434
lung8 / 33697423
lymph1 / 4427022
lymph node2 / 9161021
mammary gland4 / 15327126
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord2 / 13680146
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221666_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts105.85
Adipocyte10.15
AdrenalCortex8.4
Adrenalgland4.6
Amygdala5.65
Appendix5.35
AtrioventricularNode4.15
BDCA4+_DentriticCells608.15
Bonemarrow43.4
BronchialEpithelialCells73.7
CD105+_Endothelial9
CD14+_Monocytes1184.1
CD19+_BCells(neg._sel.)113.7
CD33+_Myeloid666.45
CD34+269.65
CD4+_Tcells23.9
CD56+_NKCells218.7
CD71+_EarlyErythroid5.1
CD8+_Tcells34.25
CardiacMyocytes9.2
Caudatenucleus4.85
Cerebellum4.5
CerebellumPeduncles6.2
CiliaryGanglion3.75
CingulateCortex5.45
Colorectaladenocarcinoma26.45
DorsalRootGanglion4.1
FetalThyroid5.3
Fetalbrain5.05
Fetalliver4.8
Fetallung9.05
GlobusPallidus4
Heart60.85
Hypothalamus5.9
Kidney4.4
Leukemia_chronicMyelogenousK-5625
Leukemia_promyelocytic-HL-604.8
Leukemialymphoblastic(MOLT-4)4.2
Liver8.4
Lung250.75
Lymphnode21.85
Lymphoma_burkitts(Daudi)7
Lymphoma_burkitts(Raji)8
MedullaOblongata4.85
OccipitalLobe4.8
OlfactoryBulb4.35
Ovary3.75
Pancreas5.75
PancreaticIslet8.2
ParietalLobe5.8
Pituitary6.35
Placenta5.9
Pons5.05
PrefrontalCortex6.05
Prostate30.8
Salivarygland4.4
SkeletalMuscle6.85
Skin6.1
SmoothMuscle35.05
Spinalcord5.8
SubthalamicNucleus4.8
SuperiorCervicalGanglion5.7
TemporalLobe4.9
Testis4.65
TestisGermCell4.35
TestisIntersitial4.55
TestisLeydigCell5.35
TestisSeminiferousTubule4.55
Thalamus5.5
Thymus30.9
Thyroid7.05
Tongue6.85
Tonsil26.4
Trachea6.5
TrigeminalGanglion5.5
Uterus8.8
UterusCorpus5.45
WholeBlood423.05
Wholebrain4.55
colon84.9
pineal_day6.44
pineal_night6.5
retina7.375
small_intestine66.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P26629
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.4 ± 0.39
Basal Forebrain5.52 ± 0.52
Basal Part of Pons6.05 ± 0.37
Cerebellar Cortex6.09 ± 0.37
Cerebellar Nuclei6.69 ± 0.24
Claustrum5.13 ± 0.98
Epithalamus6.5 ± 0.62
Frontal Lobe5.26 ± 0.69
Globus Pallidus6.12 ± 0.65
Hypothalamus5.86 ± 0.8
Insula5.52 ± 0.39
Limbic Lobe5.07 ± 0.52
Mesencephalon5.47 ± 0.62
Myelencephalon5.5 ± 0.65
Occipital Lobe5.13 ± 0.77
Parietal Lobe5.27 ± 0.54
Pontine Tegmentum5.23 ± 0.54
Striatum5.47 ± 0.66
Subthalamus6.12 ± 0.08
Temporal Lobe5.61 ± 0.51
Thalamus5.32 ± 0.49
White Matter5.66 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PycardCBCerebellum0.1
0.24
PycardCTXCerebral cortex0.59
0.94
PycardHIPHippocampal region0.09
0.14
PycardHPFHippocampal formation0.13
0.21
PycardHYHypothalamus0.02
0.01
PycardLSXLateral septal complex0
0
PycardMBMidbrain0.29
0.6
PycardMYMedulla0.05
0.06
PycardOLFOlfactory bulb0.96
1.54
PycardPPons0.12
0.14
PycardPALPallidum0.09
0.07
PycardRHPRetrohippocampal region0.2
0.28
PycardsAMYStriatum-like amygdalar nuclei0.1
0.04
PycardSTRStriatum0.05
0.07
PycardSTRdStriatum dorsal region0.04
0.07
PycardSTRvStriatum ventral region0.05
0.09
PycardTHThalamus0.09
0.1
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ASC_HUMAN_0 0 0 0 ARDAILDALENLTAEELKK PRIDE
ASC_HUMAN_0 0 0 0 DAILDALENLTAEELK PRIDE
ASC_HUMAN_0 0 0 0 DAILDALENLTAEELKK PRIDE
ASC_HUMAN_0 0 0 0 DLLLQALR PRIDE
ASC_HUMAN_0 0 0 0 ESQSYLVEDLER PRIDE
ASC_HUMAN_0 0 0 0 ESQSYLVEDLERS PRIDE
ASC_HUMAN_0 0 0 0 LFSFTPAWNWTCK PRIDE
ASC_HUMAN_0 0 0 0 VLTDEQYQAVR PRIDE
ASC_HUMAN_0 0 0 0 VTNVEWLLDALYGK PRIDE
ASC_HUMAN_125 14 125 138 VTNVEWLLDALYGK PRIDE
ASC_HUMAN_139 11 139 149 VLTDEQYQAVR PRIDE
ASC_HUMAN_160 14 160 173 KLFSFTPAWNWTCK PRIDE
ASC_HUMAN_160 22 160 181 KLFSFTPAWNWTCKDLLLQALR PRIDE
ASC_HUMAN_161 13 161 173 LFSFTPAWNWTCK PRIDE
ASC_HUMAN_174 8 174 181 DLLLQALR PRIDE
ASC_HUMAN_182 12 182 193 ESQSYLVEDLER PRIDE
ASC_HUMAN_3 19 3 21 ARDAILDALENLTAEELKK PRIDE
ASC_HUMAN_41 14 41 54 GALLSMDALDLTDK PRIDE
ASC_HUMAN_5 16 5 20 DAILDALENLTAEELK PRIDE
ASC_HUMAN_5 17 5 21 DAILDALENLTAEELKK PRIDE
ASC_HUMAN_74 45 74 118 DMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHR PRIDE
PAp00032832 17 6 22 DAILDALENLTAEELKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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