AutismKB 2.0

Annotation Detail for TBK1


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Basic Information Top
Gene Symbol:TBK1 ( FLJ11330,NAK,T2K )
Gene Full Name: TANK-binding kinase 1
Band: 12q14.2
Quick LinksEntrez ID:29110; OMIM: 604834; Uniprot ID:TBK1_HUMAN; ENSEMBL ID: ENSG00000183735; HGNC ID: 11584
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus18 / 56401231
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor10 / 26384537
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma6 / 7175583
non-neoplasia4 / 9725041
normal130 / 336030738
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder2 / 2975767
blood3 / 12347824
bone2 / 7165527
bone marrow1 / 4880120
brain36 / 110098932
cervix1 / 4817120
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye1 / 2110544
heart4 / 8962644
intestine9 / 23447238
kidney19 / 21177789
larynx0 / 241450 
liver2 / 2077439
lung8 / 33697423
lymph2 / 4427045
lymph node11 / 91610120
mammary gland4 / 15327126
mouth1 / 6705214
muscle2 / 10771518
nerve2 / 15768126
ovary2 / 10205119
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta10 / 28082535
prostate9 / 18934547
salivary gland0 / 201550 
skin12 / 21057456
spleen1 / 5395218
stomach1 / 9661910
testis35 / 330442105
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218520_at
Cell line Expression level Expression bar
721_B_lymphoblasts205.55
Adipocyte39.6
AdrenalCortex43.2
Adrenalgland34.2
Amygdala46.25
Appendix58.5
AtrioventricularNode30.65
BDCA4+_DentriticCells50.4
Bonemarrow39.8
BronchialEpithelialCells40.55
CD105+_Endothelial47.6
CD14+_Monocytes73.1
CD19+_BCells(neg._sel.)61.45
CD33+_Myeloid139.1
CD34+58.75
CD4+_Tcells57.45
CD56+_NKCells258.95
CD71+_EarlyErythroid54.4
CD8+_Tcells62.9
CardiacMyocytes50.2
Caudatenucleus34.9
Cerebellum27.9
CerebellumPeduncles47.4
CiliaryGanglion33.05
CingulateCortex64.3
Colorectaladenocarcinoma36.8
DorsalRootGanglion32.55
FetalThyroid39.8
Fetalbrain41.05
Fetalliver35.4
Fetallung44.4
GlobusPallidus38.55
Heart32.3
Hypothalamus77.15
Kidney32.45
Leukemia_chronicMyelogenousK-56238.95
Leukemia_promyelocytic-HL-6062.75
Leukemialymphoblastic(MOLT-4)25.6
Liver36.2
Lung37.9
Lymphnode43.65
Lymphoma_burkitts(Daudi)90.15
Lymphoma_burkitts(Raji)61.45
MedullaOblongata60.1
OccipitalLobe59.55
OlfactoryBulb35.95
Ovary29.15
Pancreas36.35
PancreaticIslet72.25
ParietalLobe44.7
Pituitary65.1
Placenta39.45
Pons57.45
PrefrontalCortex58.95
Prostate37.5
Salivarygland47.5
SkeletalMuscle47
Skin33.5
SmoothMuscle54.15
Spinalcord45.4
SubthalamicNucleus40.5
SuperiorCervicalGanglion47.3
TemporalLobe40.15
Testis35.3
TestisGermCell122.45
TestisIntersitial61.35
TestisLeydigCell91.05
TestisSeminiferousTubule83.8
Thalamus81.5
Thymus24.5
Thyroid51.65
Tongue44.65
Tonsil44.5
Trachea34.05
TrigeminalGanglion43.2
Uterus36.9
UterusCorpus37.45
WholeBlood99.5
Wholebrain30.8
colon41.25
pineal_day52.4
pineal_night50.38
retina55.7
small_intestine40.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13817_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.18 ± 0.46
Basal Forebrain5.09 ± 0.25
Basal Part of Pons5.45 ± 0.27
Cerebellar Cortex5.4 ± 0.38
Cerebellar Nuclei5.28 ± 0.41
Claustrum5.7 ± 0.4
Epithalamus5.07 ± 0.37
Frontal Lobe5.25 ± 0.4
Globus Pallidus5.59 ± 0.22
Hypothalamus5.17 ± 0.36
Insula5.34 ± 0.38
Limbic Lobe5.27 ± 0.35
Mesencephalon5.34 ± 0.41
Myelencephalon5.29 ± 0.42
Occipital Lobe5.58 ± 0.32
Parietal Lobe5.42 ± 0.37
Pontine Tegmentum5.4 ± 0.39
Striatum5.05 ± 0.48
Subthalamus5.66 ± 0.12
Temporal Lobe5.28 ± 0.41
Thalamus5.69 ± 0.34
White Matter5.86 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tbk1CBCerebellum19.28
21.8
Tbk1CTXCerebral cortex57.93
47.17
Tbk1HIPHippocampal region37.6
49.52
Tbk1HPFHippocampal formation33.89
37.95
Tbk1HYHypothalamus25.58
22.12
Tbk1LSXLateral septal complex100
88.3
Tbk1MBMidbrain18.49
17.97
Tbk1MYMedulla33.3
38.92
Tbk1OLFOlfactory bulb44.9
39.18
Tbk1PPons22.22
26.41
Tbk1PALPallidum24.08
22.5
Tbk1RHPRetrohippocampal region27.32
22.53
Tbk1sAMYStriatum-like amygdalar nuclei19.3
14.47
Tbk1STRStriatum22.45
17.35
Tbk1STRdStriatum dorsal region13.03
9.51
Tbk1STRvStriatum ventral region42.68
31.8
Tbk1THThalamus59.36
58.35
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00032208 20 252 271 AENGPIDWSGDMPVSCSLSR Peptide Atlas
TBK1_HUMAN_135 9 135 143 DIKPGNIMR PRIDE
TBK1_HUMAN_155 8 155 162 LTDFGAAR PRIDE
TBK1_HUMAN_309 15 309 323 MVIHVFSLQQMTAHK PRIDE
TBK1_HUMAN_526 20 526 545 LSPGGSLADAWAHQEGTHPK PRIDE
TBK1_HUMAN_526 22 526 547 LSPGGSLADAWAHQEGTHPKDR PRIDE
TBK1_HUMAN_575 10 575 584 LAYNEEQIHK PRIDE
TBK1_HUMAN_588 9 588 596 QKLYYHATK PRIDE
TBK1_HUMAN_623 5 623 627 MLHLR PRIDE
TBK1_HUMAN_647 15 647 661 YQEYTNELQETLPQK PRIDE
TBK1_HUMAN_703 11 703 713 ELAENNHILER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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