AutismKB 2.0

Annotation Detail for DDX25


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Basic Information Top
Gene Symbol:DDX25 ( GRTH )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
Band: 11q24.2
Quick LinksEntrez ID:29118; OMIM: 607663; Uniprot ID:DDX25_HUMAN; ENSEMBL ID: ENSG00000109832; HGNC ID: 18698
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult17 / 19391218
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal113 / 336030733
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain50 / 110098945
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis74 / 330442223
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219945_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.95
Adipocyte6.05
AdrenalCortex7.2
Adrenalgland5.65
Amygdala13.15
Appendix7.3
AtrioventricularNode5.1
BDCA4+_DentriticCells5.85
Bonemarrow6.9
BronchialEpithelialCells6
CD105+_Endothelial5.75
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5.8
CD33+_Myeloid7.75
CD34+6.55
CD4+_Tcells6.4
CD56+_NKCells6.55
CD71+_EarlyErythroid5.9
CD8+_Tcells5.3
CardiacMyocytes9.9
Caudatenucleus11.85
Cerebellum8.4
CerebellumPeduncles7.7
CiliaryGanglion5.25
CingulateCortex14.5
Colorectaladenocarcinoma6.2
DorsalRootGanglion5.8
FetalThyroid6.3
Fetalbrain18.4
Fetalliver5.75
Fetallung4.85
GlobusPallidus14.55
Heart8.95
Hypothalamus15.75
Kidney5.6
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-605.6
Leukemialymphoblastic(MOLT-4)7.6
Liver8.8
Lung6.5
Lymphnode5.2
Lymphoma_burkitts(Daudi)8.3
Lymphoma_burkitts(Raji)9
MedullaOblongata10.25
OccipitalLobe17.15
OlfactoryBulb4.95
Ovary4.45
Pancreas4.9
PancreaticIslet7.5
ParietalLobe8.75
Pituitary21.1
Placenta6.25
Pons9.05
PrefrontalCortex10.2
Prostate7.05
Salivarygland5.35
SkeletalMuscle8.95
Skin5.4
SmoothMuscle7
Spinalcord8.35
SubthalamicNucleus7.2
SuperiorCervicalGanglion8.6
TemporalLobe10.2
Testis199.8
TestisGermCell91.65
TestisIntersitial87.95
TestisLeydigCell183.95
TestisSeminiferousTubule111.3
Thalamus8.8
Thymus4.7
Thyroid7.95
Tongue6.9
Tonsil6.15
Trachea5.25
TrigeminalGanglion7.25
Uterus5
UterusCorpus5.9
WholeBlood6.85
Wholebrain17.2
colon6.3
pineal_day12.18
pineal_night9.56
retina7.75
small_intestine5.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6124_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.77 ± 0.45
Basal Forebrain6.9 ± 0.22
Basal Part of Pons6.9 ± 0.51
Cerebellar Cortex6.61 ± 0.18
Cerebellar Nuclei6.33 ± 0.46
Claustrum6.59 ± 0.54
Epithalamus6.67 ± 0.4
Frontal Lobe6.85 ± 0.38
Globus Pallidus5.98 ± 0.5
Hypothalamus7.26 ± 0.25
Insula7.08 ± 0.24
Limbic Lobe6.71 ± 0.56
Mesencephalon6.65 ± 0.57
Myelencephalon6.63 ± 0.56
Occipital Lobe6.26 ± 0.55
Parietal Lobe6.71 ± 0.47
Pontine Tegmentum6.63 ± 0.53
Striatum6.48 ± 0.52
Subthalamus6.99 ± 0.53
Temporal Lobe6.9 ± 0.4
Thalamus6.53 ± 0.38
White Matter4.39 ± 0.39
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DDX25_HUMAN_150 11 150 160 TAAFVLAMLSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018