AutismKB 2.0

Annotation Detail for GRM4


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Basic Information Top
Gene Symbol:GRM4 ( GPRC1D,MGC177594,MGLUR4,mGlu4 )
Gene Full Name: glutamate receptor, metabotropic 4
Band: 6p21.31
Quick LinksEntrez ID:2914; OMIM: 604100; Uniprot ID:GRM4_HUMAN; ENSEMBL ID: ENSG00000124493; HGNC ID: 4596
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus1 / 5640121
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult10 / 19391215
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal195 / 336030758
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain188 / 1100989170
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210234_at
Cell line Expression level Expression bar
721_B_lymphoblasts31.2
Adipocyte31.55
AdrenalCortex44.8
Adrenalgland27.35
Amygdala34.3
Appendix28
AtrioventricularNode38.55
BDCA4+_DentriticCells29.75
Bonemarrow34.8
BronchialEpithelialCells30.6
CD105+_Endothelial30.4
CD14+_Monocytes30.95
CD19+_BCells(neg._sel.)32.7
CD33+_Myeloid39.6
CD34+32.15
CD4+_Tcells40.05
CD56+_NKCells32
CD71+_EarlyErythroid28.55
CD8+_Tcells36.75
CardiacMyocytes38.6
Caudatenucleus29.85
Cerebellum98.15
CerebellumPeduncles159.75
CiliaryGanglion26.55
CingulateCortex38.1
Colorectaladenocarcinoma32.2
DorsalRootGanglion27.3
FetalThyroid30.9
Fetalbrain38.05
Fetalliver26
Fetallung26.5
GlobusPallidus25.15
Heart43.4
Hypothalamus35.1
Kidney28.8
Leukemia_chronicMyelogenousK-56228.95
Leukemia_promyelocytic-HL-6027.35
Leukemialymphoblastic(MOLT-4)26.3
Liver41.35
Lung35.1
Lymphnode37.25
Lymphoma_burkitts(Daudi)41.35
Lymphoma_burkitts(Raji)44.35
MedullaOblongata30
OccipitalLobe30.9
OlfactoryBulb25.3
Ovary21.25
Pancreas42.25
PancreaticIslet34.1
ParietalLobe35.1
Pituitary53.65
Placenta33
Pons42.9
PrefrontalCortex36.7
Prostate38.2
Salivarygland25.8
SkeletalMuscle42.25
Skin32.7
SmoothMuscle34.25
Spinalcord33.6
SubthalamicNucleus37.35
SuperiorCervicalGanglion36.4
TemporalLobe28.9
Testis28
TestisGermCell33.7
TestisIntersitial27
TestisLeydigCell37.2
TestisSeminiferousTubule28.05
Thalamus44.6
Thymus28.5
Thyroid40.8
Tongue46.5
Tonsil40.2
Trachea27.15
TrigeminalGanglion33.15
Uterus26.2
UterusCorpus29.3
WholeBlood31.9
Wholebrain24.95
colon31.85
pineal_day36.18
pineal_night36.7
retina35.7
small_intestine31.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_322_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.26 ± 1.2
Basal Forebrain2.1 ± 0.58
Basal Part of Pons2.16 ± 0.72
Cerebellar Cortex3.08 ± 0.54
Cerebellar Nuclei2.36 ± 0.7
Claustrum2.48 ± 0.98
Epithalamus1.73 ± 0.73
Frontal Lobe2 ± 0.85
Globus Pallidus1.62 ± 0.93
Hypothalamus1.8 ± 0.67
Insula2.02 ± 0.95
Limbic Lobe2.24 ± 0.7
Mesencephalon2.33 ± 0.96
Myelencephalon2.16 ± 0.84
Occipital Lobe2.46 ± 0.87
Parietal Lobe2 ± 0.83
Pontine Tegmentum2.09 ± 0.69
Striatum2.45 ± 0.94
Subthalamus1.67 ± 0.88
Temporal Lobe1.92 ± 0.86
Thalamus2.25 ± 0.68
White Matter2.13 ± 0.81
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grm4CBCerebellum100
100
Grm4CTXCerebral cortex100
100
Grm4HIPHippocampal region61
90.83
Grm4HPFHippocampal formation86.5
100
Grm4HYHypothalamus57.44
51.98
Grm4LSXLateral septal complex98.83
89.04
Grm4MBMidbrain74.69
77.94
Grm4MYMedulla80.09
100
Grm4OLFOlfactory bulb100
100
Grm4PPons70.58
85.7
Grm4PALPallidum49.53
45.31
Grm4RHPRetrohippocampal region100
100
Grm4sAMYStriatum-like amygdalar nuclei84.47
68.88
Grm4STRStriatum100
95.68
Grm4STRdStriatum dorsal region100
100
Grm4STRvStriatum ventral region95.98
87.41
Grm4THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00009916 12 244 255 EDGGVCIAQSVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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