AutismKB 2.0

Annotation Detail for GSK3B


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Basic Information Top
Gene Symbol:GSK3B ( - )
Gene Full Name: glycogen synthase kinase 3 beta
Band: 3q13.33
Quick LinksEntrez ID:2932; OMIM: 605004; Uniprot ID:GSK3B_HUMAN; ENSEMBL ID: ENSG00000082701; HGNC ID: 4617
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus27 / 56401247
neonate1 / 3109732
infant1 / 2362042
juvenile1 / 5555617
adult121 / 193912162
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor12 / 26384545
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia8 / 9584283
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal152 / 336030745
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma3 / 4635664
skin tumor13 / 124949104
soft tissue/muscle tissue tumor27 / 125191215
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood6 / 12347848
bone1 / 7165513
bone marrow1 / 4880120
brain26 / 110098923
cervix3 / 4817162
connective tissue27 / 149255180
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye18 / 21105485
heart3 / 8962633
intestine10 / 23447242
kidney7 / 21177733
larynx0 / 241450 
liver6 / 20774328
lung9 / 33697426
lymph0 / 442700 
lymph node13 / 91610141
mammary gland6 / 15327139
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary5 / 10205148
pancreas10 / 21481246
parathyroid6 / 20539292
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta14 / 28082549
prostate8 / 18934542
salivary gland0 / 201550 
skin17 / 21057480
spleen0 / 539520 
stomach3 / 9661931
testis13 / 33044239
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209945_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts36.95
Adipocyte15.2
AdrenalCortex15.8
Adrenalgland12.6
Amygdala15.35
Appendix14.7
AtrioventricularNode11.05
BDCA4+_DentriticCells18.65
Bonemarrow14.8
BronchialEpithelialCells67.4
CD105+_Endothelial15
CD14+_Monocytes34.5
CD19+_BCells(neg._sel.)32.35
CD33+_Myeloid27.6
CD34+18.35
CD4+_Tcells15.65
CD56+_NKCells39
CD71+_EarlyErythroid14.15
CD8+_Tcells17.65
CardiacMyocytes18.5
Caudatenucleus8.15
Cerebellum11.8
CerebellumPeduncles21.4
CiliaryGanglion8.8
CingulateCortex15.15
Colorectaladenocarcinoma14.8
DorsalRootGanglion9
FetalThyroid45.8
Fetalbrain19.5
Fetalliver12.65
Fetallung12.25
GlobusPallidus9.85
Heart18.45
Hypothalamus14.3
Kidney11.8
Leukemia_chronicMyelogenousK-56212.75
Leukemia_promyelocytic-HL-6012.8
Leukemialymphoblastic(MOLT-4)17.4
Liver23.25
Lung18.25
Lymphnode12.2
Lymphoma_burkitts(Daudi)18.9
Lymphoma_burkitts(Raji)19.9
MedullaOblongata13.5
OccipitalLobe13
OlfactoryBulb11.65
Ovary9.8
Pancreas17.8
PancreaticIslet15.9
ParietalLobe15.6
Pituitary17.2
Placenta25.1
Pons13.95
PrefrontalCortex23.35
Prostate17.1
Salivarygland10.75
SkeletalMuscle15.65
Skin12.8
SmoothMuscle17.85
Spinalcord14.05
SubthalamicNucleus15.8
SuperiorCervicalGanglion16.4
TemporalLobe13.05
Testis27.4
TestisGermCell26.35
TestisIntersitial56.5
TestisLeydigCell20.65
TestisSeminiferousTubule34.85
Thalamus13.2
Thymus27.45
Thyroid16.45
Tongue14.6
Tonsil14.25
Trachea12.2
TrigeminalGanglion14.9
Uterus11.9
UterusCorpus13.15
WholeBlood42.35
Wholebrain15.1
colon18.75
pineal_day22.44
pineal_night27.26
retina16
small_intestine26.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_327_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.02 ± 0.51
Basal Forebrain7.22 ± 0.24
Basal Part of Pons7.54 ± 0.39
Cerebellar Cortex7.52 ± 0.2
Cerebellar Nuclei7.25 ± 0.36
Claustrum6.85 ± 0.41
Epithalamus7.02 ± 0.54
Frontal Lobe7.44 ± 0.36
Globus Pallidus6.28 ± 0.31
Hypothalamus7.62 ± 0.28
Insula7.41 ± 0.2
Limbic Lobe7.21 ± 0.55
Mesencephalon7.28 ± 0.44
Myelencephalon7.21 ± 0.5
Occipital Lobe7.05 ± 0.56
Parietal Lobe7.37 ± 0.43
Pontine Tegmentum7.21 ± 0.52
Striatum6.65 ± 0.39
Subthalamus7.41 ± 0.66
Temporal Lobe7.39 ± 0.4
Thalamus7.25 ± 0.42
White Matter6.26 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gsk3bCBCerebellum31.47
69.66
Gsk3bCTXCerebral cortex100
100
Gsk3bHIPHippocampal region86.11
100
Gsk3bHPFHippocampal formation100
100
Gsk3bHYHypothalamus99.77
98.81
Gsk3bLSXLateral septal complex95.48
91.78
Gsk3bMBMidbrain83.65
91.75
Gsk3bMYMedulla43.06
66.69
Gsk3bOLFOlfactory bulb68.54
81.89
Gsk3bPPons55.44
77.89
Gsk3bPALPallidum75.6
91.01
Gsk3bRHPRetrohippocampal region100
100
Gsk3bsAMYStriatum-like amygdalar nuclei100
100
Gsk3bSTRStriatum100
100
Gsk3bSTRdStriatum dorsal region100
100
Gsk3bSTRvStriatum ventral region100
94.08
Gsk3bTHThalamus92.42
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00011773 21 7 27 TTSFAESCKPVQQPSAFGSMK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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