AutismKB 2.0

Annotation Detail for GSN


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GSN ( DKFZp313L0718 )
Gene Full Name: gelsolin
Band: 9q33.2
Quick LinksEntrez ID:2934; OMIM: 137350; Uniprot ID:GELS_HUMAN; ENSEMBL ID: ENSG00000148180; HGNC ID: 4620
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus104 / 564012184
neonate24 / 31097771
infant1 / 2362042
juvenile7 / 55556125
adult631 / 1939121325
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor28 / 94178297
cervical tumor1 / 3436629
chondrosarcoma15 / 82823181
colorectal tumor50 / 114246437
esophageal tumor8 / 17290462
gastrointestinal tumor63 / 119369527
germ cell tumor43 / 263845162
glioma30 / 106883280
head and neck tumor80 / 136302586
kidney tumor43 / 68959623
leukemia69 / 95842719
liver tumor7 / 9635972
lung tumor12 / 103127116
lymphoma0 / 717550 
non-neoplasia50 / 97250514
normal1296 / 3360307385
ovarian tumor8 / 76682104
pancreatic tumor78 / 104616745
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer9 / 10268087
retinoblastoma0 / 463560 
skin tumor119 / 124949952
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor28 / 90257310
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue47 / 131063586
adrenal gland5 / 33197150
ascites31 / 40015774
bladder2 / 2975767
blood41 / 123478332
bone15 / 71655209
bone marrow19 / 48801389
brain524 / 1100989475
cervix8 / 48171166
connective tissue54 / 149255361
ear3 / 16212185
embryonic tissue15 / 21572269
esophagus9 / 20209445
eye93 / 211054440
heart62 / 89626691
intestine136 / 234472580
kidney103 / 211777486
larynx7 / 24145289
liver15 / 20774372
lung66 / 336974195
lymph0 / 442700 
lymph node11 / 91610120
mammary gland51 / 153271332
mouth80 / 670521193
muscle28 / 107715259
nerve10 / 15768634
ovary19 / 102051186
pancreas101 / 214812470
parathyroid10 / 20539486
pharynx9 / 41328217
pituitary gland4 / 16585241
placenta54 / 280825192
prostate49 / 189345258
salivary gland2 / 2015599
skin162 / 210574769
spleen35 / 53952648
stomach64 / 96619662
testis43 / 330442130
thymus16 / 81131197
thyroid25 / 47473526
tonsil1 / 1699958
trachea26 / 52413496
umbilical cord5 / 13680365
uterus100 / 232878429
vascular21 / 51780405
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214040_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.45
Adipocyte30.95
AdrenalCortex11.75
Adrenalgland8.2
Amygdala8.65
Appendix24.25
AtrioventricularNode8.6
BDCA4+_DentriticCells47.2
Bonemarrow10.6
BronchialEpithelialCells8.25
CD105+_Endothelial8.25
CD14+_Monocytes9
CD19+_BCells(neg._sel.)8.25
CD33+_Myeloid11.65
CD34+10.15
CD4+_Tcells8.3
CD56+_NKCells9.6
CD71+_EarlyErythroid8.3
CD8+_Tcells7.15
CardiacMyocytes13.45
Caudatenucleus7.95
Cerebellum7.25
CerebellumPeduncles11.3
CiliaryGanglion9.05
CingulateCortex8.95
Colorectaladenocarcinoma11
DorsalRootGanglion8.15
FetalThyroid8.5
Fetalbrain8
Fetalliver8.25
Fetallung6.3
GlobusPallidus6.95
Heart37.2
Hypothalamus9.8
Kidney9.1
Leukemia_chronicMyelogenousK-5627.25
Leukemia_promyelocytic-HL-607.6
Leukemialymphoblastic(MOLT-4)6.05
Liver13.55
Lung92.5
Lymphnode7.1
Lymphoma_burkitts(Daudi)11.35
Lymphoma_burkitts(Raji)13
MedullaOblongata8.25
OccipitalLobe7.85
OlfactoryBulb15.9
Ovary6.7
Pancreas7.3
PancreaticIslet9.4
ParietalLobe11
Pituitary10.6
Placenta8.7
Pons10.65
PrefrontalCortex10.8
Prostate9.95
Salivarygland7.2
SkeletalMuscle17.2
Skin8.35
SmoothMuscle9.75
Spinalcord11.1
SubthalamicNucleus8.25
SuperiorCervicalGanglion17.35
TemporalLobe8.75
Testis7.6
TestisGermCell7.1
TestisIntersitial8
TestisLeydigCell8.9
TestisSeminiferousTubule7.65
Thalamus8.9
Thymus7.65
Thyroid88.05
Tongue13.2
Tonsil8.55
Trachea39.8
TrigeminalGanglion13.65
Uterus26.05
UterusCorpus11.45
WholeBlood9.35
Wholebrain7.1
colon25.6
pineal_day10.74
pineal_night10.12
retina70.875
small_intestine14.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_328_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.08 ± 0.68
Basal Forebrain10.19 ± 0.36
Basal Part of Pons10.11 ± 0.5
Cerebellar Cortex9.44 ± 0.34
Cerebellar Nuclei10.37 ± 0.34
Claustrum10.34 ± 0.49
Epithalamus9.42 ± 0.73
Frontal Lobe9.98 ± 0.61
Globus Pallidus11.28 ± 0.38
Hypothalamus9.95 ± 0.42
Insula9.64 ± 0.59
Limbic Lobe9.95 ± 0.7
Mesencephalon10.11 ± 0.53
Myelencephalon10.02 ± 0.6
Occipital Lobe9.89 ± 0.73
Parietal Lobe9.81 ± 0.54
Pontine Tegmentum9.84 ± 0.49
Striatum10.33 ± 0.55
Subthalamus9.79 ± 0.05
Temporal Lobe9.76 ± 0.61
Thalamus10.17 ± 0.46
White Matter11.78 ± 0.21
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GsnCBCerebellum51.59
66.71
GsnCTXCerebral cortex46.84
40.45
GsnHIPHippocampal region37
43.54
GsnHPFHippocampal formation41.64
43.26
GsnHYHypothalamus55.66
48.52
GsnLSXLateral septal complex57.24
55.54
GsnMBMidbrain65.11
63.68
GsnMYMedulla78.85
76.37
GsnOLFOlfactory bulb49.92
47.95
GsnPPons74.92
72.74
GsnPALPallidum65.96
61.45
GsnRHPRetrohippocampal region46.75
40.43
GsnsAMYStriatum-like amygdalar nuclei51.4
48.68
GsnSTRStriatum53.45
49.07
GsnSTRdStriatum dorsal region57.37
53.88
GsnSTRvStriatum ventral region37.45
29.14
GsnTHThalamus71.24
66.92
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GELS_HUMAN_0 0 0 0 AGALNSNDAFVLK PRIDE
GELS_HUMAN_0 0 0 0 DPDQTDGLGLSYLSSHIANVER PRIDE
GELS_HUMAN_0 0 0 0 DSQEEEKTEALTSAK PRIDE
GELS_HUMAN_0 0 0 0 EVQGFESATFLGYFK PRIDE
GELS_HUMAN_0 0 0 0 QTQVSVLPEGGETPLFK PRIDE
GELS_HUMAN_0 0 0 0 TPSAAYLWVGTGASEAEK PRIDE
GELS_HUMAN_0 0 0 0 TPSAAYLWVGTGASEAEKTGAQELLR PRIDE
GELS_HUMAN_0 0 0 0 VPFDAATLHTSTAMAAQHGMDDDGTGQK PRIDE
GELS_HUMAN_147 15 147 161 EVQGFESATFLGYFK PRIDE
GELS_HUMAN_148 15 148 162 EVQGFESATFLGYFK PRIDE
GELS_HUMAN_177 11 177 187 HVVPNEVVVQR PRIDE
GELS_HUMAN_178 11 178 188 HVVPNEVVVQR PRIDE
GELS_HUMAN_257 38 257 294 VHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANR PRIDE
GELS_HUMAN_257 39 257 295 VHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRK PRIDE
GELS_HUMAN_302 25 302 326 VSNGAGTMSVSLVADENPFAQGALK PRIDE
GELS_HUMAN_303 25 303 327 VSNGAGTMSVSLVADENPFAQGALK PRIDE
GELS_HUMAN_327 11 327 337 SEDCFILDHGK PRIDE
GELS_HUMAN_327 14 327 340 SEDCFILDHGKDGK PRIDE
GELS_HUMAN_373 17 373 389 QTQVSVLPEGGETPLFK PRIDE
GELS_HUMAN_374 17 374 390 QTQVSVLPEGGETPLFK PRIDE
GELS_HUMAN_394 25 394 418 NWRDPDQTDGLGLSYLSSHIANVER PRIDE
GELS_HUMAN_398 22 398 419 DPDQTDGLGLSYLSSHIANVER PRIDE
GELS_HUMAN_419 28 419 446 VPFDAATLHTSTAMAAQHGMDDDGTGQK PRIDE
GELS_HUMAN_420 28 420 447 VPFDAATLHTSTAMAAQHGMDDDGTGQK PRIDE
GELS_HUMAN_525 23 525 547 VVQGKEPAHLMSLFGGKPMIIYK PRIDE
GELS_HUMAN_530 18 530 547 EPAHLMSLFGGKPMIIYK PRIDE
GELS_HUMAN_584 13 584 596 AGALNSNDAFVLK PRIDE
GELS_HUMAN_585 13 585 597 AGALNSNDAFVLK PRIDE
GELS_HUMAN_597 18 597 614 TPSAAYLWVGTGASEAEK PRIDE
GELS_HUMAN_597 26 597 622 TPSAAYLWVGTGASEAEKTGAQELLR PRIDE
GELS_HUMAN_598 18 598 615 TPSAAYLWVGTGASEAEK PRIDE
GELS_HUMAN_61 11 61 71 AGKEPGLQIWR PRIDE
GELS_HUMAN_61 14 61 74 AGKEPGLQIWRVEK PRIDE
GELS_HUMAN_616 8 616 623 TGAQELLR PRIDE
GELS_HUMAN_626 22 626 647 AQPVQVAEGSEPDGFWEALGGK PRIDE
GELS_HUMAN_661 8 661 668 KMDAHPPR PRIDE
GELS_HUMAN_713 15 713 727 DSQEEEKTEALTSAK PRIDE
GELS_HUMAN_72 27 72 98 VEKFDLVPVPTNLYGDFFTGDAYVILK PRIDE
PAp00025063 15 97 111 EVQGFESATFLGYFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved